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8,371 articles

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Dentistry

Advancing Cariogenic Risk Assessment: A Quantitative Framework for Oral pH Dynamics

This article explores a novel quantitative framework using nonlinear mixed effects modeling to improve characterization of oral pH dynamics, enhancing caries risk prediction and supporting clinical and translational research.

Nov 11, 2026
Cardiology

Plozasiran: A Novel siRNA Therapy Reducing Severe Hypertriglyceridemia and Pancreatitis Risk

Plozasiran, targeting APOC3 mRNA, significantly lowers triglyceride levels and reduces acute pancreatitis incidence in severe hypertriglyceridemia patients, according to pooled data from two placebo-controlled trials.

Nov 11, 2026
Rehabilitation Medicine

Evaluating the Use of Vision-Face-Arm-Speech-Time (V-FAST) in Stroke Admissions: A Comparative Study with NIH Stroke Scale and Orthoptist Assessment in an Emergency Department

This study assesses the effectiveness of the V-FAST checklist in detecting visual impairments in suspected stroke patients compared to NIH Stroke Scale and orthoptist evaluation in an emergency setting.

Nov 10, 2026
Dentistry

Targeting the Autotaxin/Lysophosphatidic Acid Axis: A Novel Approach to Modulate Bone Loss and Inflammation in Periodontitis

This article explores how the autotaxin/lysophosphatidic acid axis regulates macrophage-driven osteoclastogenesis and inflammation in periodontitis, highlighting the therapeutic potential of autotaxin inhibitors to prevent alveolar bone res

Nov 10, 2026
Cardiology

Long-term Comparative Outcomes of PCI with Drug-Eluting Stents Versus CABG in Left Main Coronary Artery Disease: Insights from the IRIS-MAIN Registry

A decade-long multicentre Asian registry analysis revealed no significant difference in all-cause mortality between PCI with drug-eluting stents and CABG for unprotected left main coronary artery disease, highlighting the need for individua

Nov 10, 2026
Respiratory

Middle Lobe Displacement Post Lobectomy in a Child With Congenital Pulmonary Airway Malformation

A 9-year-old girl underwent right upper lobectomy for type 1 CPAM; postoperative right middle lobe displacement led to bronchial obstruction and persistent cough, highlighting rare complications after pediatric lobectomy.

Nov 10, 2026
Rheumatology

Targeting Nicotinamide N-Methyltransferase: A Novel Approach to Mitigate Fibroblast Activation and Skin Fibrosis in Systemic Sclerosis

This article explores the pivotal role of Nicotinamide N-methyltransferase (NNMT) in fibroblast activation and extracellular matrix deposition driving skin fibrosis in systemic sclerosis, highlighting therapeutic potential of NNMT inhibitio

Nov 10, 2026
Transplantation

Serum Periostin at One Year Predicts Chronic Lung Allograft Dysfunction Post-Lung Transplant: A Multicenter Validation Study

Serum periostin measured one year after lung transplantation correlates with subsequent chronic lung allograft dysfunction, offering a promising biomarker for early risk stratification.

Nov 10, 2026
Allergy & Immunology

Dual T Helper 17/Type 2 Immune Dysregulation in Taiwanese Psoriasis: Implications for Precision Medicine

This study reveals a distinctive dual Th17/Th2 immune endotype and pronounced IL-36 activation in Taiwanese patients with psoriasis, highlighting the need for tailored therapeutic approaches in this ethnic group.

Nov 10, 2026
Plastic Surgery

High-Frequency Ultrasound in DIEP Flap Breast Reconstruction: Anatomical Insights Without Perfusion Predictive Value

This study evaluates high-frequency ultrasound’s role in visualizing midline crossing-over vessels in DIEP flap breast reconstruction and finds no correlation between ultrasound-detected vessel characteristics and intraoperative flap

Nov 10, 2026
Critical Care

Traumatic Brain Injury Impairs Pulmonary Defense: Insights from Mouse and Pig Models Revealing Neutrophil Dysfunction

Traumatic brain injury (TBI) compromises lung bacterial clearance by disrupting neutrophil function, increasing infection susceptibility as demonstrated in murine and porcine models and supported by human plasma studies.

Nov 10, 2026
Emergency Medicine

Who’s on Airway? Evaluating Pediatric Trainee Tracheal Intubation Frequency and Outcomes in Academic Settings Using NEAR4PEM Data

This study analyzes tracheal intubation success and safety among pediatric emergency trainees, revealing comparable performance between emergency medicine residents and PEM fellows, while highlighting lower success and higher adverse events

Nov 10, 2026
Internal Medicine

Reducing Mental Health Stigma in Primary Care: Impact of Behavioral Health Training on Clinician Attitudes

Participation in a structured behavioral health training program among primary care providers is linked to significantly lower mental health stigma, suggesting education as a key strategy to improve equitable mental health care.

Nov 10, 2026
Hematology-Oncology

BCMA-Directed CAR T-Cell Therapy Shows Promise for Durable, Drug-Free Remission in Refractory Primary Immune Thrombocytopenia

A first-in-human study demonstrates that BCMA-targeted CAR T-cell therapy induces rapid, sustained platelet recovery and durable drug-free remission in refractory primary immune thrombocytopenia with manageable safety.

Nov 10, 2026
Respiratory

Noninvasive Assessment of Inspiratory Effort and Lung Mechanics via Airway Occlusion during NIV: A Multicenter Study

Airway occlusion maneuvers during noninvasive ventilation offer reliable, noninvasive measurements of inspiratory effort and lung mechanics, improving clinical monitoring in hypoxemic patients post-extubation.

Nov 10, 2026
Ophthalmology

Optimizing Remote Home Tonometry Duration for Precise Intraocular Pressure Fluctuation Assessment

This study establishes that 7 to 10 consecutive days of remote home tonometry are required to accurately capture intraocular pressure fluctuations, essential for effective glaucoma management.

Nov 10, 2026
Otorhinolaryngology

Topical Tranexamic Acid in Acute Spontaneous Epistaxis: Enhancing Hemostasis with a Targeted Approach

This randomized controlled trial demonstrates that topical tranexamic acid effectively achieves initial hemostasis in acute spontaneous epistaxis, though it does not significantly reduce early rebleeding rates within 24 hours.

Nov 10, 2026
Gastroenterology

Reversing the Irreversible: Evidence for Cirrhosis Regression in Compensated MASH Cirrhosis Following Metabolic Bariatric Surgery

Metabolic bariatric surgery induces significant histologic regression of cirrhosis and fibrosis remodeling in patients with compensated metabolic dysfunction-associated steatohepatitis (MASH) cirrhosis, challenging the notion that cirrhosis

Nov 10, 2026
OB/GYN & Women's Health

Enhanced Hepatitis C Treatment Access Through an Antenatal Linkage-to-Care Bundle: A Health System Quality Improvement

Implementation of the HALT-C antenatal linkage-to-care bundle significantly increased hepatitis C treatment initiation and completion by six months postpartum, with majority of patients preferring antenatal therapy, demonstrating pregnancy

Nov 10, 2026
Gastroenterology

Chemoprevention of Hepatocellular Carcinoma by Next-Generation Antipsychotic Aripiprazole: Mechanistic Insights and Translational Perspectives

Aripiprazole, an atypical antipsychotic, shows promising chemopreventive effects against hepatocellular carcinoma (HCC) via antifibrotic, anti-inflammatory, and tumor-suppressive mechanisms involving liver fibroblasts, macrophages, and canc

Nov 10, 2026
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    Precision Medicine for Long QT Syndrome Type 2: Lumacaftor Corrects Trafficking Defects and Shortens QT Interval

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    Optimizing Postoperative Opioid Prescriptions After Intra-Abdominal Cancer Surgery: Comparing the 5x-Multiplier and 3-Tier Models

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