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Cluster analysis of physiological parameters in women with urgency urinary incontinence reveals three distinct phenotypes, offering insights for personalized treatment strategies.
Pudendal nerve palsy occurs frequently after hip arthroscopy using a perineal post, with symptoms commonly resolving by one year. Increased traction duration and force are significant risk factors, and persistent symptoms impair hip-specifi
A pivotal phase 3 trial demonstrates improved event-free and overall survival with perioperative durvalumab combined with neoadjuvant enfortumab vedotin, with or without tremelimumab, versus surgery alone in muscle-invasive bladder cancer p
This randomized trial demonstrates that periurethral estradiol cream application is noninferior to intravaginal application for preventing recurrent urinary tract infections in postmenopausal individuals, with comparable efficacy and improv
FGFR alterations, especially in FGFR3 and FGFR2, are pivotal biomarkers in urothelial carcinoma, advancing personalized diagnosis, treatment, and monitoring across disease stages. Emerging molecular diagnostics and targeted therapies promis
A multicenter study shows similar 14-day treatment failure rates among first-, second-, and third-generation oral cephalosporins for outpatient pyelonephritis, supporting flexibility in antibiotic choice post-ED discharge.
This study compares PSA screening and biopsy rates between Veterans Affairs and Fee-for-Service Medicare, revealing that VA care is more closely aligned with patients’ likelihood of benefit, particularly in older men and those with li
A national survey reveals that most US surgeons report high workload hours and a majority perceive their workload as excessive, with factors such as years in practice, gender, and specialty influencing burden perception.
The PURSUE multicenter study demonstrates that implementing Enhanced Recovery After Surgery protocols in pediatric patients undergoing complex lower urinary tract reconstruction significantly improves adherence to perioperative care standar
This study reveals that psychological stress, anxiety, PTSD, and military sexual trauma are linked to increased urinary incontinence severity and affect response to behavioral treatments among women veterans, underscoring the importance of
A clear, practice-focused summary of the 2026 ASCO living guideline on systemic treatment of metastatic castration‑resistant prostate cancer, emphasizing biomarker-driven choices, sequencing, and new options such as 177Lu‑PSMA and PARP inhi
A retrospective modeling study of 53 prostate cancer patients found that mechanism-based biomarkers derived from first-cycle PSA dynamics predicted time to progression and survival under adaptive therapy, outperforming standard PSA metrics. The approach could support personalized treatment scheduling.
Mathematical biomarkers derived from initial PSA dynamics effectively predict adaptive therapy outcomes in prostate cancer, enabling personalized treatment strategies that outperform traditional PSA measures.
This retrospective cohort study of 887 women reveals long-term outcomes of retropubic and transobturator midurethral slings for stress urinary incontinence, showing higher reoperation rates with transobturator slings, especially when combin
A randomized trial demonstrates that removing urinary catheters at home on postoperative day 1 is noninferior to removal on days 3-4 regarding urinary retention rates, with high patient satisfaction and low complications, supporting earlier
This study of 800 men with infertility demonstrates that a detailed pathophysiology-based classification reduces idiopathic cases and identifies distinct endocrine profiles, enabling targeted management.
The Stockholm3 test combined with MRI screening significantly improves detection of clinically significant prostate cancer compared to PSA alone, reducing missed cases and unnecessary biopsies in a population-based study with 2-year follow-
In a nationwide U.S. analysis of 21,010 adult DCD kidney transplants, normothermic regional perfusion lowered delayed graft function, shortened hospital stay, and improved graft and patient survival, with the greatest benefit in higher-risk
A phase 2 randomized trial found that 12 weeks of testosterone cypionate improved sexual activity, desire, mood, body composition, and exercise performance in hypogonadal men after radical prostatectomy, with no biochemical recurrence obser
In a large Medicare study, hospitals under Maryland’s global budget model showed modest but significant improvements in cancer surgery outcomes, driven by fewer complications and shorter stays, with lower inpatient spending.
