Psychiatry
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Ecopipam Reduced Relapse Risk in Pediatric Tourette Syndrome Without Metabolic or Extrapyramidal Signal in a Phase 3 Randomized Withdrawal Trial
In a phase 3 randomized withdrawal trial, ecopipam maintained tic improvement in pediatric Tourette syndrome over 24 weeks and showed a generally favorable safety profile without clinically meaningful weight, metabolic, or drug-induced move
Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy Versus Right Unilateral Ultra-Brief Electroconvulsive Therapy in Depression
Magnetic seizure therapy was non-inferior to right unilateral ultra-brief ECT for depression remission and caused less autobiographical memory worsening, suggesting a promising convulsive treatment option with better cognitive safety.
Interleukin 6 as a Treatment Target for Depression: A Proof-of-Concept Randomized Clinical Trial
A small randomized trial found that blocking IL-6 with tocilizumab showed promising, clinically meaningful trends for inflammation-related, hard-to-treat depression, especially for somatic symptoms, fatigue, anxiety, and quality of life, th
Internet-Based CBT for Tinnitus Shows Durable Benefit Up to 6 Years, but Long-Term Interpretation Requires Caution
A 6-year follow-up of guided internet-based CBT for tinnitus found sustained reductions in tinnitus distress, with smaller persistent gains in mood and sleep, despite substantial attrition and the absence of a long-term control group.
Internet-Based CBT for Tinnitus Shows Durable Benefit Up to 6 Years, With Sustained Reduction in Distress but More Modest Auditory Gains
A 6-year follow-up study suggests guided internet-based CBT for tinnitus can produce durable reductions in tinnitus distress, with sustained but smaller benefits for mood, insomnia, and life satisfaction.
Longitudinal Risk for Suicidal Self-Directed Violence Among Veterans With Cancer
A national study of veterans with cancer found elevated suicide-related risk that persisted for years, especially among younger, unmarried, frail, or mentally ill patients and those with certain cancers such as central nervous system and th
Polygenic Scores Often Rival Recurrent CNVs for Psychiatric Risk Stratification, but Both Add Clinical Insight
A large Danish genetic study suggests recurrent CNVs and polygenic scores provide complementary psychiatric risk information, with polygenic scores often identifying more at-risk individuals and potentially modifying CNV-associated risk.
Integrating Rare and Common Variants: The Synergistic Role of rCNVs and Polygenic Scores in Psychiatric Risk Stratification
This review synthesizes evidence on how recurrent copy number variants (rCNVs) and polygenic scores (PGSs) jointly influence psychiatric risk, highlighting their complementary roles in clinical risk assessment and the emergence of precision
When Severe Mental Illness Meets Lung Cancer: Why Equal Treatment Still Isn’t Guaranteed
A large Japanese study found that people with schizophrenia spectrum disorders were less likely to receive several standard treatments for non-small cell lung cancer, underscoring a persistent and preventable gap in cancer care.
Patients With Schizophrenia Spectrum Disorder Are Less Likely to Receive Stage-Appropriate Treatment for Non-Small Cell Lung Cancer in Japan
A nationwide Japanese cohort study found that patients with schizophrenia spectrum disorder and NSCLC presented with more advanced disease and were less likely to receive surgery, adjuvant chemotherapy, or systemic therapy.
Association Between Delivery Mode and Postpartum Psychiatric Conditions
A large U.S. cohort study found higher rates of postpartum psychiatric conditions after planned or unplanned cesarean delivery, but not after successful operative vaginal delivery, highlighting the need for closer postpartum mental health f
Semaglutide Improves Insulin Sensitivity in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial
In a 30-week randomized trial, semaglutide improved insulin sensitivity, reduced insulin resistance, lowered fasting glucose, and produced substantial weight loss in patients with schizophrenia and prediabetes taking second-generation antip
Health Plan Disenrollment and Mortality After Starting Medications for Opioid Use Disorder
A large cohort study found that health plan disenrollment after starting buprenorphine or naltrexone for opioid use disorder was linked to higher all-cause and overdose mortality, highlighting the importance of continuous coverage and treat
Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression: The EPISODE Randomized Clinical Trial
Psilocybin-assisted psychotherapy showed promising but inconclusive antidepressant effects in treatment-resistant depression, with notable acute adverse events and safety concerns.
Implementation of a Hospital-Based Screening and Treatment Program for Unhealthy Alcohol Use
A hospital-based screening and treatment program for unhealthy alcohol use was feasible in a diverse safety-net population and was linked to short-term reductions in alcohol risk scores, especially among patients who received follow-up and
Patient-Derived Neuronal Synapse Deficits Predict Brain Network Abnormalities and Cognitive Impairment in Schizophrenia
A multimodal translational study links genetically driven synaptic deficits in patient-derived neurons to cortical structure, electrophysiology, and cognition in schizophrenia, supporting biologically informed stratification of cognitive im
Extended-Release vs Sublingual Buprenorphine in Pregnancy Through 12 Months Post Partum: A Randomized Clinical Trial
A clinical trial found that weekly extended-release buprenorphine significantly improves illicit opioid abstinence during pregnancy compared to sublingual forms, with fewer serious adverse events, offering a safer treatment option for opioi
Initiation of Medications for Alcohol Use Disorder Among Hospitalized Veterans : A Retrospective Cohort Study
VHA study reveals only 30% of veterans hospitalized for AUD receive evidence-based medications during or shortly after hospitalization, with significant variation across hospitals and demographic factors influencing prescription rates.
A CBT-Based Mobile App Significantly Reduced Tinnitus Distress in a Sham-Controlled Randomized Trial
In a 60-patient randomized trial, a digital therapeutic app delivering tinnitus education and CBT elements produced large, durable reductions in tinnitus-related distress over 16 weeks, with no serious safety concerns.
Intersection of Intimate Partner Violence and Substance Use Disorders in the Veteran Population: Screening Gaps, Risk Profiles, and Lethality
This review synthesizes evidence on the high prevalence and severity of intimate partner violence (IPV) among veterans with substance use disorders, highlighting gender-specific lethality risks and the critical need for integrated screening
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