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This study reveals persistent structural brain alterations and evolving psychiatric symptoms in post-acute NMDA receptor encephalitis, highlighting the need for focused long-term care and advanced imaging markers.
A recent randomized clinical trial reveals that adjunctive intravenous ketamine significantly reduces depressive symptoms in treatment-resistant bipolar depression, with good safety and tolerability compared to midazolam.
This study reveals significantly reduced ACE protein levels in cerebrospinal fluid and serum of early-stage psychosis patients, particularly in treatment-resistant cases, highlighting a potential biomarker and mechanistic role beyond enzyma
A large Danish cohort study reveals that partner similarity for psychiatric disorders significantly inflates both prevalence and heritability estimates, highlighting important public health and genetic counseling implications.
This review synthesizes evidence demonstrating disrupted gastrointestinal interoception in weight-restored anorexia nervosa, linking behavioral and neural disturbances with relapse risk and symptom severity, and highlighting novel mechanist
This study highlights how daily feelings of guilt are central drivers of negative emotional burdens in diabetes, influencing emotional well-being and risk of distress and depression.
This statewide cohort study reveals significantly higher incidence and earlier onset of systemic physical multimorbidity among people with schizophrenia-spectrum or bipolar disorders compared to matched controls, highlighting urgent needs f
This large-scale meta-analysis identifies specific brain structural alterations—mainly in cortical surface area and subcortical volumes—associated with bulimia nervosa diagnosis and symptom severity, advancing understanding of its neurobiol
A Danish cohort study reveals decreased genetic risk profiles in recent ASD and ADHD diagnoses, supporting broader diagnostic criteria as a driver of rising incidence rates.
This review synthesizes evidence on the relationship between antipsychotic choice after traumatic brain injury (TBI) and post-traumatic epilepsy risk in older adults, highlighting recent population-based findings and mechanistic implication
This report describes the use of dexmedetomidine infusion for sedation in severely agitated adolescents in the ED, highlighting its feasibility as a bridge therapy while awaiting psychiatric care.
An 8-week trial reveals that intranasal oxytocin increases the free T3/free T4 ratio and correlates with improved mental health-related quality of life in adults with obesity, suggesting thyroid axis modulation as a potential mechanism for
Early initiation of methadone take-home dosing (5-24 weeks post-induction) reduces mortality and treatment discontinuation, surpassing benefits seen with no take-home dosing. Flexible dosing policies improve retention without increasing ove
A randomized trial found telehealth mindfulness group visits improve chronic low back pain more than usual care, highlighting a scalable, non-drug treatment option.
This study highlights how early physiologic markers like shock index and hypotension can predict PTSD risk in gunshot wound survivors, while blood transfusion shows an inverse relationship, aiding targeted mental health interventions.
This article explores the unique challenges autistic transgender and gender diverse adults face in adhering to gender-affirming hormone therapy (GAHT) and highlights strategies to support effective therapy adherence in clinical endocrinolog
This review synthesizes current evidence on the impact of continuing psychostimulant treatment during pregnancy on postpartum mental health outcomes among people with ADHD, highlighting key findings and clinical implications from recent lar
Few US adults with alcohol or opioid use disorder reported addiction pharmacotherapy use in 2022-2023. Pharmacotherapy receipt was linked to increased healthcare utilization, underscoring the need for early outpatient intervention strategie
The ODDESSI trial evaluated Open Dialogue versus treatment as usual in adults presenting in mental health crisis, finding no reduction in relapse time but improved service outcomes and reduced inpatient admissions with Open Dialogue.
Genomic testing holds promise for guiding preventive strategies in psychiatry, particularly in high-risk and clinically uncertain contexts; however, current evidence supports targeted rather than universal approaches.
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