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This study highlights how timing of palliative radiotherapy in gynecologic cancers influences end-of-life care quality, with late radiation associated with less aggressive care and better supportive outcomes compared to radiation administer
A recent study demonstrates the feasibility and safety of hybrid indocyanine green and technetium-99m nanoparticle fluorescence imaging for sentinel lymph node biopsy in early-stage vulvar cancer, improving detection rates and oncologic out
A multicenter prospective study comparing laparoscopic radiofrequency ablation and myomectomy in symptomatic uterine leiomyomas reveals both improve symptoms and quality of life, with myomectomy showing modest but clinically non-significant
A randomized clinical trial found that hip extension at crowning does not reduce significant perineal lacerations during first vaginal deliveries, with no clear benefit over usual flexed positioning.
This review synthesizes evidence on the cost-effectiveness of standalone salpingectomy for ovarian cancer prevention, highlighting its benefits primarily in women at moderately elevated risk, especially between ages 45-50, supporting tailor
This study reveals that polyendocrine metabolic ovarian syndrome (PMOS) during pregnancy increases risks of early gestational diabetes and adverse neonatal outcomes, underscoring the need for timely identification and management to improve
This article reviews the establishment of international standardized reference ranges for plasma estradiol in postmenopausal women, highlighting the influence of BMI and assay harmonization using CDC standards, with implications for therapy
This study highlights how HPV and TP53 molecular subtyping in stage I vulvar squamous cell carcinoma delineates survival outcomes and recurrence risks, supporting its role in personalized management strategies.
Recent randomized trials show no survival benefit of RhD-positive whole blood over component therapy in trauma, underscoring the need to protect reproductive potential by prioritizing RhD-negative transfusions and follow-up.
This article offers clinicians an evidence-based guide to hormonal options for managing perimenopause, highlighting the distinct physiology, symptom spectrum, and individualized treatment strategies including contraceptives and alternative
This study reveals the population prevalence and incident risk of HPA-1a alloimmunisation in pregnancy across diverse ethnic groups, highlighting its rarity and establishing a framework for risk assessment in foetal-neonatal alloimmune thro
This secondary analysis of the REPAIR study identifies prolonged active second stage labor, deep tears, and physician involvement in suturing as risk factors for perineal wound complications, while prophylactic antibiotics reduce this risk.
This Swedish cohort study reveals growing gestational diabetes prevalence with marked disparities by social determinants such as education, income, and nativity, underscoring the need for targeted prevention and equitable care.
This study examines how episiotomy type influences the risk of obstetric anal sphincter injury during operative vaginal deliveries, highlighting mediolateral episiotomy’s protective effect in women without prior vaginal birth and risk
Five-year data from KEYNOTE-826 confirm pembrolizumab combined with chemotherapy as a durable, first-line treatment improving survival in persistent, recurrent, or metastatic cervical cancer without new safety concerns.
Initiation of menopausal hormone therapy during perimenopause or early postmenopause in women with vasomotor symptoms is associated with a reduced cardiovascular risk, especially among Black women and those starting therapy within 10 years
This multicenter study reveals that total-body irradiation (TBI) conditioning before hematopoietic stem cell transplantation severely compromises pregnancy outcomes compared to alkylating agents or conventional chemotherapy in female surviv
This study reveals distinct alterations in the type I interferon pathway expression and signaling linked to mutated p53 subtypes in endometrial cancer, highlighting differing immune microenvironments that impact prognosis and therapeutic co
This retrospective study compares oncologic and perioperative outcomes of minimally invasive radical hysterectomy without uterine manipulator versus open radical hysterectomy in early-stage cervical cancer, showing comparable survival but i
Large-scale proteomic analysis identifies novel maternal plasma protein biomarkers that improve detection of fetal death beyond established markers, highlighting both shared and unique pathological pathways with preeclampsia.
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