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The FS-ICUshort, a validated 12-item questionnaire, maintains robust psychometric properties of the original FS-ICU while enhancing feasibility and completion rates, facilitating routine family satisfaction assessment and quality benchmarki
This study investigates how decisions made by patients versus surrogates affect the intensity of end-of-life care and hospitalization costs in ICU settings, revealing that surrogate decisions often lead to higher care intensity and costs, p
A comprehensive 15-year population-based study in Catalonia reveals that over 40% of sepsis survivors die within two years post-discharge, highlighting significant impacts of age, comorbidities, and hospital stay duration on long-term outco
A study using causal forest algorithms reveals heterogeneous benefits of high flow nasal oxygen in immunocompromised patients with acute respiratory failure, identifying subgroups who may significantly avoid invasive mechanical ventilation.
Traumatic brain injury (TBI) compromises lung bacterial clearance by disrupting neutrophil function, increasing infection susceptibility as demonstrated in murine and porcine models and supported by human plasma studies.
Airway occlusion maneuvers during noninvasive ventilation offer reliable, noninvasive measurements of inspiratory effort and lung mechanics, improving clinical monitoring in hypoxemic patients post-extubation.
Higher ICU patient volume for severely ill patients, as stratified by SOFA scores, is linked to lower in-hospital mortality, with the effect more pronounced at greater illness severity.
Abdominal solid organ transplant recipients with sepsis show improved survival linked to distinctive immune and metabolic signatures, including attenuated inflammation and preserved innate immunity, providing novel insights for clinical man
The PROSpect trial found no improvement in ventilator-free days with prone positioning or HFOV compared to conventional ventilation in children with moderate-to-severe PARDS, cautioning against their routine first-line use due to safety con
This RCT explored music therapy’s role during invasive mechanical ventilation weaning in ICU patients, showing benefits in agitation reduction, sedation needs, and tracheostomy rates, though weaning duration was unaffected.
This multicenter study shows cenobamate is effective and safe as adjunctive therapy for refractory focal-onset status epilepticus, improving seizure control and outcomes.
Early primary care follow-up within 7 days after pediatric ICU discharge is significantly associated with reduced acute care use, including emergency visits and rehospitalizations, highlighting a critical opportunity to improve post-critica
Delayed appropriate antifungal therapy after the onset of persistent hypotension dramatically increases mortality in Candida septic shock; survival drastically improves with treatment within 2 hours.
A validated clinical model predicting survival after pediatric extracorporeal cardiopulmonary resuscitation reveals significant inter-hospital outcome variability, underscoring the importance of risk-standardized benchmarking in pediatric i
This article explores how AI could transform critical care by illustrating potential benefits, harms, and ethical challenges through ten parables, guiding clinicians and policymakers in preparing for AI’s integration amid uncertainty.
This study examines differences in effect estimates between cluster-randomized and individually randomized clinical trials in prehospital, emergency, and critical care, revealing systematic bias in length-of-stay outcomes but not mortality.
Sepsis triggers mitochondrial impairment in platelets, promoting hyperactivation via ROS production. The mitochondria-specific antioxidant MitoTEMPO reverses these changes in vitro, suggesting therapeutic potential to prevent sepsis-related
An analysis of 27,773 pediatric tracheal intubations reveals 1.2% associated cardiac arrest, highlighting preventable factors such as multiple intubation attempts and benefits linked to video laryngoscopy and specific medications.
A significant brachial-to-radial arterial pressure gradient occurs in nearly one-fifth of critically ill patients receiving vasoactive agents, correlating with higher vasoactive doses, greater illness severity, and increased ICU mortality.
A deep learning model identifying ARDS features on chest X-rays independently predicts 28-day mortality and ventilator duration beyond traditional clinical measures in patients undergoing invasive mechanical ventilation.
