Critical Care
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TNF-α–Driven Immune-Endothelial Injury Emerges as a Therapeutic Target in Severe Acute Pancreatitis
Single-cell analysis of human severe acute pancreatitis identifies TNF-α–induced CD8+ T-cell endothelial injury as a driver of pancreatic microcirculatory failure, supporting TNF-α blockade as a potential targeted therapy.
Impact of Appropriate Antimicrobial Therapy on ICU Patient Outcomes: Subanalysis of the DIANA Study Dataset
In critically ill ICU patients with confirmed bacterial infections, appropriate empiric antimicrobial therapy was common and independently linked to lower 28-day mortality and more antimicrobial-free days.
Enteral vs IV Magnesium Replacement in Critically Ill Patients: A Randomized Noninferiority Trial
A randomized ICU trial found oral/enteral magnesium was not proven noninferior to IV replacement for correcting mild-to-moderate hypomagnesemia, but it lowered urinary magnesium loss, cost, waste, carbon emissions, and IV fluid use.
Extracorporeal Cardiopulmonary Resuscitation for Pediatric Out-of-Hospital Cardiac Arrest
In selected children with out-of-hospital cardiac arrest, extracorporeal CPR was associated with higher one-month survival and better neurologic outcomes than continued conventional CPR, though the study was observational and estimates were
Avoiding Intensive Systolic Blood Pressure Lowering After Successful Thrombectomy May Improve 1-Year Stroke Recovery: The OPTIMAL-BP Extension
In OPTIMAL-BP 1-year follow-up, targeting systolic BP
Four Oxygenation Trajectories Define Reproducible Clinical Archetypes in Persistent Acute Respiratory Failure
A multi-cohort study identified four reproducible 14-day oxygenation trajectory classes in persistent acute hypoxemic respiratory failure, with distinct mortality, biomarker patterns, and links to ARDS and hyperinflammatory subphenotypes.
Liberal Transfusion Still Appears Favored in Myocardial Infarction With Anemia, Regardless of Critical Illness Status
A MINT trial subanalysis found no evidence that ICU status changes the relative effect of restrictive versus liberal transfusion in acute myocardial infarction with anemia.
Prone Positioning for Severe Hypoxemia Rose Sharply During COVID-19 but Was Not Sustained Across North American ICUs
In 37 North American hospitals, proning of eligible mechanically ventilated patients increased markedly during COVID-19, then fell post-pandemic, with substantial interhospital variation throughout.
Hospital-Acquired DRESS and Clinical Severity Strongly Predict ICU Admission in a 39-Centre Paris Cohort
In this multicentre cohort of 207 hospitalized adults with DRESS, 17% required ICU care. Hospital-acquired DRESS and greater clinical severity independently predicted ICU admission, while ICU mortality reached 20%.
Frequent Pre-Admission Ambulatory Visits May Flag Harmful Diagnostic Error Risk in High-Risk General Medicine Inpatients
In a retrospective cohort of high-risk medical inpatients, frequent ambulatory care use before admission emerged as a predictor of harmful diagnostic error, highlighting a potentially actionable EHR-based signal for hospital diagnostic safe
Out-of-Bed Armchair Positioning Improves Oxygenation in Spontaneously Breathing ICU Patients
A randomized ICU trial found that sitting spontaneously breathing patients in an armchair for 3 hours improved oxygenation more than staying semi-recumbent in bed, with no serious adverse events.
ICU Readmission Raises 60-Day Mortality Substantially Regardless of Frailty, but Frail Patients Carry the Highest Absolute Risk
In a binational registry study of 615,719 ICU admissions, ICU readmission was linked to a similar absolute increase in 60-day mortality in frail and nonfrail patients, although frail readmitted patients had the highest overall mortality.
ABRUPT2 Trial: 5% Albumin Reduced Fluid Requirements in Major Burn Resuscitation
ABRUPT2 found that adding 5% albumin to lactated Ringer’s significantly reduced fluid needs in the first 48 hours after major burns, without clear differences in mortality, kidney injury, or healing time.
Cardiogenic Shock Care Still Varies Widely Across CICUs, Especially in the Choice of Inodilators
A large CCCTN analysis found major institutional and patient-level variation in vasoactive drug selection for cardiogenic shock, highlighting persistent evidence gaps in choosing dobutamine, milrinone, and other vasoactive therapies.
Difficulty Paying for Medical Care: Links to Psychological Distress and Healthcare Perceptions Among ICU Caregivers
More than half of ICU caregivers in a multicenter U.S. study reported difficulty paying for patient care, and financial strain was linked to higher posttraumatic stress, anxiety, depression, decisional regret, and medical mistrust.
New SCCM–ESICM Consensus Defines Refractory Septic Shock
A new SCCM–ESICM Delphi consensus standardizes clinical criteria for refractory septic shock, focusing on persistent hypoperfusion, fluid unresponsiveness, high vasopressor needs, and bedside ultrasound when mixed shock is suspected.
More Enteral Protein Did Not Overcome Anabolic Resistance in Mechanically Ventilated Critical Illness
In a randomized trial, a 40 g intraduodenal whey bolus increased amino acid availability but did not significantly raise postprandial muscle protein synthesis versus 20 g in critically ill ventilated adults.
Predicted Body Weight May Be Too High for Many Critically Ill Women: New Evidence Challenges a Core Assumption in Lung-Protective Ventilation
A large analysis suggests the predicted body weight equation overestimates lung size in critically ill women, increasing the risk of higher driving pressures and contributing to excess mortality under standard tidal-volume targeting.
急性白血病危重成人患者的時間趨勢和預後因素：個體參與者數據薈萃分析
這項涵蓋19國55個ICU的2003名患者研究發現，急性白血病危重患者總體ICU死亡率為45%，需機械通氣者達66%。年齡>65歲、AML診斷、化療期間入院等因素顯著增加死亡風險，但隨時間推移生存率有所改善。
Household Income Decline and Job Loss Among Survivors of Critical Illness: A Nationwide Cohort Study
A large South Korean study reveals critical illness survivors face severe socioeconomic consequences, with 27.6% experiencing income decline and 12.3% job loss within a year, disproportionately affecting high-income households despite unive
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