Neurology
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When Does an ICP Crisis Really Count? BOOST II Raises Questions About Bedside Detection in Severe TBI
A post hoc BOOST II analysis found that many bedside-labeled intracranial pressure crises were not confirmed by continuous electronic data, challenging current ICP episode definitions in severe traumatic brain injury.
Retinal Microvascular Clues to Alzheimer Disease: What Swept-Source OCT Angiography Reveals About Neurovascular Dysfunction
SS-OCTA identified retinal and choriocapillaris microvascular changes associated with cognitive status in Alzheimer disease, including thinner GCC in dementia and a biphasic CCFD pattern, suggesting a promising noninvasive biomarker platfor
A New Way to Measure Prodromal Synucleinopathy: What the PSRS Adds for RBD Clinical Trials
The PSRS showed good-to-excellent reliability and moderate-to-strong construct validity in a large RBD cohort, supporting its use as a multidomain measure of prodromal synucleinopathy burden.
Brain Imaging Biomarkers and Cognitive Outcomes in a Multidomain Lifestyle Intervention: The POINTER Imaging Ancillary Study
The POINTER Imaging study found no overall brain biomarker changes from a structured lifestyle intervention, but participants with lower baseline hippocampal volume showed greater cognitive benefit, suggesting imaging may help identify who
Multiple Sclerosis Does Not Appear to Worsen In-Hospital Outcomes After Cardiovascular Surgery, but Routine Home Discharge Is Less Common
A large US inpatient analysis found similar in-hospital mortality and complication rates after cardiovascular surgery in patients with and without multiple sclerosis, but patients with MS were less often discharged routinely home.
Ultra-Early Remote Ischemic Postconditioning After Thrombectomy Appears Safe but Does Not Improve 90-Day Stroke Recovery
In the EnTRIPS randomized trial, ultra-early remote ischemic postconditioning after successful endovascular thrombectomy was safe but did not significantly improve 90-day functional independence in acute ischemic stroke.
Postmenopausal Migraine Signals Higher Ischemic Stroke Risk, Not Hemorrhagic Stroke, in the Women’s Health Initiative
In a large cohort of postmenopausal women, migraine history was associated with a modest increase in ischemic stroke risk over 20 years, while total and hemorrhagic stroke risks were not significantly elevated.
Hypertension-Related High-Risk Features May Identify Which Patients With Cryptogenic Stroke Benefit From Apixaban Instead of Aspirin
An exploratory ARCADIA analysis suggests that patients with cryptogenic stroke and atrial cardiopathy without severe hypertension-related features may derive greater benefit from apixaban than aspirin, whereas those with high-risk hypertens
Wider Intracranial Arteries, Not Cranial Arterial Stenosis, Track With Lacunar Stroke and Cerebral Small-Vessel Disease
In a prospective mild stroke cohort, cranial arterial stenosis was not linked to cSVD, whereas basilar dolichoectasia and wider intracranial arteries were strongly associated with lacunar stroke, higher cSVD burden, incident infarcts, and w
Identification of Genetic Modifiers of Autosomal Dominant Alzheimer’s Disease: A Genome-Wide Association Study
A genome-wide study identified three genetic modifiers of autosomal dominant Alzheimer’s disease, linking them to disease risk, earlier onset, and biomarker changes involving amyloid, tau, TDP-43, and brain aging.
Acute Brain Injury in New-Onset Refractory Status Epilepticus and Etiology-Defined Status Epilepticus
This study found that cryptogenic NORSE causes severe, rapidly rising neuroaxonal injury, measured by NfL, and that higher NfL predicts worse short-term outcome. S100B was not useful for distinguishing groups.
Acute Cardiac CT Added to Stroke Imaging Detects Cardiac Thrombi in About 1 in 16 Patients and Outperforms Transthoracic Echocardiography
In a 3919-patient individual-level meta-analysis, acute cardiac CT detected cardiac thrombi in 6.2% of ischemic stroke cases, exceeded transthoracic echocardiography yield, added modest imaging burden, and identified patients with worse 90-
Why Prevalence Is Rising Differently in Parkinson Disease, Multiple Sclerosis, and Motor Neuron Diseases
A large Sweden-France analysis suggests rising MS prevalence is mainly survival-driven, increasing MND prevalence reflects growing incidence, and PD prevalence rises modestly through mixed demographic and survival effects.
Mechanical Thrombectomy and Final Infarct Volume in Medium or Distal Vessel Occlusion Stroke: A Post Hoc Analysis of a Randomized Clinical Trial
In a post hoc analysis of the DISTAL trial, mechanical thrombectomy plus best medical treatment preserved more threatened brain tissue than medical treatment alone in medium or distal vessel occlusion stroke, and better tissue preservation
Ultra-High-Resolution Photon-Counting CTA Improves Noninvasive Detection of Neurovascular In-Stent Restenosis
A prospective study suggests ultra-high-resolution photon-counting CTA can detect neurovascular in-stent restenosis with excellent accuracy while reducing blooming artifacts and improving visualization of in-stent pathology.
Neurocognitive Outcomes of In Utero Exposure to Antiseizure Medication: An Australian Cohort Study
An Australian cohort study found that prenatal exposure to valproate, levetiracetam, topiramate, and carbamazepine was associated with poorer cognitive outcomes in children, while lamotrigine exposure was not.
A Two-Marker Plasma Model Closely Mirrors PET-Based Biological Staging of Alzheimer Disease
Plasma %p-tau217 plus eMTBR-tau243 showed strong agreement with amyloid/tau PET staging, tracked clinical severity, and aligned with neuropathology, supporting a scalable blood-based approach to Alzheimer disease biological staging.
Pregnancy Complications Signal Long-Term Maternal Risk of Subarachnoid Hemorrhage in a 50-Year Swedish Cohort
In a nationwide Swedish cohort, several adverse pregnancy outcomes were linked to higher long-term maternal risk of subarachnoid hemorrhage, supporting pregnancy as an early vascular stress test.
Rural-Urban Disparities in Epilepsy Outcomes in the United States
A national U.S. study found that patients with epilepsy from rural counties had worse hospital outcomes, including higher mortality, more status epilepticus, longer stays, and less EEG use, highlighting access-related disparities.
Ecopipam Reduced Relapse Risk in Pediatric Tourette Syndrome Without Metabolic or Extrapyramidal Signal in a Phase 3 Randomized Withdrawal Trial
In a phase 3 randomized withdrawal trial, ecopipam maintained tic improvement in pediatric Tourette syndrome over 24 weeks and showed a generally favorable safety profile without clinically meaningful weight, metabolic, or drug-induced move
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