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The clinical briefing

Medical news

8,371 articles

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Anesthesiology

Feasibility and Acceptability of Virtual Reality for Pain Relief During Vaso-occlusive Episodes in Sickle Cell Disease: A Pilot Study

This pilot study assesses the use of virtual reality as a feasible and acceptable non-pharmacologic adjunct to alleviate pain during vaso-occlusive episodes in adults with sickle cell disease.

Nov 12, 2026
Hematology-Oncology

Functional RIG-I in Platelets: A Novel Modulator of Thrombosis During Influenza Infection

This study reveals that the viral RNA sensor RIG-I in platelets modulates thrombotic responses during influenza infection, limiting thrombosis and facilitating immune cell transmigration through a unique signaling pathway.

Nov 12, 2026
Respiratory

Predicting COPD Onset: Validation of a Practical Pre-COPD Scoring System Across Diverse Cohorts

A novel Pre-COPD score, integrating smoking history, symptoms, asthma, and spirometry, robustly predicts incident COPD across three multinational cohorts, enabling early risk stratification and preventive strategies in clinical practice.

Nov 12, 2026
Ophthalmology

Comparative Three-Year Outcomes of Trabeculotomy Versus Combined Trabeculotomy-Trabeculectomy in Primary Congenital Glaucoma with Moderate Corneal Enlargement

A prospective randomized trial shows trabeculotomy is noninferior to combined trabeculotomy-trabeculectomy for 3-year control of intraocular pressure in primary congenital glaucoma with corneal diameter 12-14 mm, providing a less invasive s

Nov 12, 2026
Otorhinolaryngology

Cholesteatoma Recidivism: Distinguishing Pediatric Risks and Disease Patterns for Optimized Management

This study identifies pediatric age, supratubal recess involvement, mastoid extension, and surgical technique as independent predictors of cholesteatoma recidivism, highlighting the need for tailored postoperative surveillance strategies.

Nov 12, 2026
Oncology

Distinct Clinical Outcomes of Neoadjuvant PD-1 Inhibitors in Resectable Stage III Melanoma: Lymph Node Versus In-Transit Metastases

This population-based study reveals significant differences in pathological response and survival outcomes between stage III melanoma patients with lymph node metastases and those with in-transit metastases treated with neoadjuvant PD-1 inh

Nov 12, 2026
OB/GYN & Women's Health

Baclofen Vaginal Suppositories in Chronic Pelvic Pain: Efficacy from a Robust Randomized Controlled Trial and Clinical Implications

This review synthesizes evidence from a rigorously conducted RCT demonstrating the efficacy and safety of nightly baclofen vaginal suppositories for chronic pelvic pain due to pelvic floor muscle dysfunction, highlighting therapeutic advanc

Nov 12, 2026
Gastroenterology

AASLD EXPO: Modernizing the Approach to Hepatitis D — Who to Test, Who to Treat, and How to Monitor

The AASLD EXPO gives timely, consensus-driven guidance: screen all HBsAg-positive persons once for anti-HDV, confirm viremia with HDV RNA, stage with elastography, and treat compensated chronic HDV with bulevirtide (± peg‑IFN) while monitor

Nov 12, 2026
Neurology

LATE-NC and Cognitive Decline: Insights from a Diverse Brazilian Autopsy Cohort

This study reveals that LATE-NC, a common neuropathology in aging, is linked to cognitive impairment and coexisting brain lesions in a diverse Brazilian population, underscoring its significance beyond homogenous cohorts.

Nov 12, 2026
Diabetes & Endocrinology

Genetic Insights into Glycemic Response: Role of SLC2A2 Variants in Sulfonylurea Efficacy from the GRADE Trial

This article explores how common genetic variants near SLC2A2 affect glycemic response to glimepiride in type 2 diabetes, highlighting potential for precision medicine in second-line diabetes therapy.

Nov 12, 2026
Cardiology

Durable Efficacy and Safety of Percutaneous Transseptal TMVR: Two-Year Outcomes from the ENCIRCLE Trial

The ENCIRCLE trial reports sustained mitral regurgitation reduction, improved functional status, and manageable safety outcomes at 2 years after percutaneous transseptal TMVR using the SAPIEN M3 system in high-risk symptomatic MR patients.

Nov 12, 2026
Oncology

Advancing Diversity in Oncology: Trends in Racial and Ethnic Representation Among Trainees from 2011 to 2025

This article examines significant improvements in underrepresented racial and ethnic minority representation among oncology trainees post-2020, highlighting progress and ongoing disparities in the oncology workforce.

Nov 12, 2026
Orthopedics

Efficacy of a Single Autologous Stromal Vascular Fraction Injection for Moderate-to-Severe Knee Osteoarthritis: Insights from a Multicenter Randomized Controlled Trial

A 12-month multicenter RCT shows that a single intra-articular injection of 25 million autologous adipose-derived stromal vascular fraction cells significantly improves pain and function in moderate-to-severe knee osteoarthritis compared wi

Nov 12, 2026
Internal Medicine

Evaluating the Impact of PACE on Younger Adults with Disabilities: Health, Engagement, and Healthcare Utilization Outcomes

This study assesses health and care satisfaction outcomes in younger disabled adults enrolled in a Program of All-Inclusive Care for the Elderly (PACE), highlighting functional and community engagement trends, satisfaction, and healthcare u

Nov 12, 2026
Internal Medicine

Silver Diamine Fluoride vs Atraumatic Restorations for Caries Management in Older Adults: Insights from a Cluster-Randomized Trial

This cluster-randomized trial demonstrates that biannual topical 38% silver diamine fluoride is noninferior to atraumatic restorative treatments for arresting and preventing dental caries in older adults, providing a simple, effective strat

Nov 12, 2026
Diabetes & Endocrinology

Retatrutide: A Promising Triple Hormone Receptor Agonist for Obesity Management and Related Comorbidities

Retatrutide, a triple agonist targeting GIP, GLP-1, and glucagon receptors, demonstrates marked weight loss and improvement in knee osteoarthritis pain and obstructive sleep apnea in adults with obesity in a phase 3 trial.

Nov 12, 2026
Superintelligence

Anthropic CEO's Roadshow Prediction: Cancer, Heart Disease, and Other Illnesses Will Become History Within a Decade

MedXY Editorial Team | November 11, 2026 | Anthropic Recently, during a video presentation for Anthropic's IPO roadshow, CEO Dario Amodei stated that

Nov 11, 2026
Rehabilitation Medicine

Immersive Virtual Reality Enhances Naming Therapy in Chronic Post-Stroke Aphasia: A Randomized Controlled Trial

Immersive virtual reality-based naming therapy significantly improves language function, quality of life, and patient engagement in chronic post-stroke aphasia compared to conventional therapy.

Nov 11, 2026
Dentistry

Metagenomic Insights into Salivary Microbiome Shifts During Periodontal Disease Progression

Shotgun metagenomic sequencing reveals significant taxonomic and functional shifts in the salivary microbiome, correlating with stages of periodontal disease, highlighting potential biomarkers for early detection and risk stratification.

Nov 11, 2026
Nephrology

Comparative Effectiveness of Responsive Management Versus Renal Dialysis in Elderly UK Patients with Kidney Failure and Frailty: Insights from the Prepare for Kidney Care Trial and Related Advances

This review synthesizes evidence from the Prepare for Kidney Care trial and complementary studies, highlighting that in older frail or multimorbid kidney failure patients, responsive management offers similar quality-adjusted life expectanc

Nov 11, 2026
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  4. 04Cardiology

    Precision Medicine for Long QT Syndrome Type 2: Lumacaftor Corrects Trafficking Defects and Shortens QT Interval

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    Optimizing Postoperative Opioid Prescriptions After Intra-Abdominal Cancer Surgery: Comparing the 5x-Multiplier and 3-Tier Models

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