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This multicenter retrospective study demonstrates that removing central venous catheters in pediatric cancer patients with Staphylococcus aureus bloodstream infections significantly reduces both short-term and late complications compared to
Upfront whole genome and transcriptome sequencing (WGTS) improves diagnostic yield in inherited bone marrow failure syndromes (IBMFS) by identifying diverse pathogenic variants and novel mechanisms, guiding personalized patient management a
This study demonstrates the promising safety and efficacy of CD20-targeted autologous CAR T-cell therapy in BTKi-refractory Waldenström macroglobulinemia, showing an 80% deep response rate and warranting further investigation in larger tria
This pilot study assesses the use of virtual reality as a feasible and acceptable non-pharmacologic adjunct to alleviate pain during vaso-occlusive episodes in adults with sickle cell disease.
This study reveals that the viral RNA sensor RIG-I in platelets modulates thrombotic responses during influenza infection, limiting thrombosis and facilitating immune cell transmigration through a unique signaling pathway.
This article examines significant improvements in underrepresented racial and ethnic minority representation among oncology trainees post-2020, highlighting progress and ongoing disparities in the oncology workforce.
Recent evidence identifies USP22 as a key regulator of MEIS1 protein stability, revealing a promising therapeutic target to disrupt leukemogenic transcription in KMT2Ar acute leukemia.
A first-in-human study demonstrates that BCMA-targeted CAR T-cell therapy induces rapid, sustained platelet recovery and durable drug-free remission in refractory primary immune thrombocytopenia with manageable safety.
This study reveals that periodontitis in allo-HSCT patients shifts bloodstream infection profiles towards non-viridans streptococci and associates with higher mortality, highlighting the importance of oral health in transplant outcomes.
This article analyzes novel genomic alterations linked to relapse in childhood B-acute lymphoblastic leukemia (B-ALL), revealing subtype-specific mechanisms of therapeutic resistance and implications for personalized treatment strategies.
This article delineates the pivotal role of CD4+ T cells in mediating immune responses against ALK-positive anaplastic large cell lymphoma, highlighting preclinical evidence supporting immune checkpoint inhibitors as a promising therapeutic
Reduced expression of splicing factor SRSF1 disrupts LCK exon 8 inclusion, impairing TCR signaling and regulatory T-cell induction, thereby contributing to immune dysregulation in immune thrombocytopenia.
2′-FL supplementation post-allo-HSCT preserves gut microbiome diversity, enriches beneficial taxa, reduces acute GI GVHD and viral reactivation, demonstrating safety and translational potential in pediatric transplant care.
This article explores how CD7 CAR-T therapy leads to EBV-positive lymphoproliferative disorder by revealing CD7-negative T cell dysfunction, immunosuppressive macrophage niches, and EBV-driven B cell transformation through multi-omic techno
Autoimmune neutropenia (AiN) in adults, though rare, is a chronic condition predominantly affecting women with autoimmune comorbidities. Treatment prioritizes observation, with therapies aimed at boosting neutrophil counts or modulating imm
A large-scale analysis estimates the U.S. national burden of severe hemolytic disease of the fetus and newborn (HDFN) caused by anti-D, anti-K, and anti-c alloantibodies, revealing that severe HDFN is rare despite common alloimmunization.
Sepsis triggers mitochondrial impairment in platelets, promoting hyperactivation via ROS production. The mitochondria-specific antioxidant MitoTEMPO reverses these changes in vitro, suggesting therapeutic potential to prevent sepsis-related
This nationwide study reveals that donor cell-derived hematologic neoplasms (DDHN) after allogeneic stem cell transplantation are rare but linked mainly to inherited germline mutations in related donors, underscoring the need for comprehens
A long-term follow-up of the SPRINT trial shows no significant difference in recurrent stroke or mortality rates between initial low and moderate fixed doses of hydroxyurea in sickle cell disease, emphasizing event clustering within the fir
The phase 3 RISE UP trial demonstrates that mitapivat significantly improves hemoglobin levels in sickle cell disease, offering a novel, well-tolerated oral treatment with potential to modify disease outcomes.
