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Irregular Sleep Timing in Surgeons May Increase Postoperative Major Adverse Events
A multicenter prospective cohort study suggests that substantial surgeon social jet lag, but not midsleep variability alone, is associated with higher 30-day major adverse event risk after surgery and correlates with surgeon burnout.
Severe Maternal Morbidity at Delivery Is Linked to Shorter and Less Exclusive Breastfeeding in Nulliparous U.S. Patients
In a large prospective U.S. cohort, severe maternal morbidity did not reduce breastfeeding initiation, but it was associated with lower odds of breastfeeding beyond 6 months and of exclusive breastfeeding.
Rural-Urban Disparities in Epilepsy Outcomes in the United States
A national U.S. study found that patients with epilepsy from rural counties had worse hospital outcomes, including higher mortality, more status epilepticus, longer stays, and less EEG use, highlighting access-related disparities.
Food Coloring Additives Linked to Higher Type 2 Diabetes Risk in a Large French Cohort
A large French cohort study found that higher exposure to several food coloring additives was associated with increased incidence of type 2 diabetes, highlighting the need for further research and possible reevaluation of some additives.
Long-Term Wildfire Smoke PM2.5 Exposure Is Linked to Higher Incident Stroke Risk in Older US Adults
In a nationwide Medicare cohort, chronic wildfire smoke PM2.5 exposure was associated with a modest but significant increase in incident stroke, with stronger effects over longer exposure windows.
Association Between Emergency Department Undertriage or Overtriage With Timeliness of Care and Patient Outcomes
A large multicenter study found that emergency department triage mismatches were linked to small delays in care and longer stays, especially for overtriaged patients. Better use of patient history may improve triage accuracy.
Mailed Outreach for Colorectal Cancer Screening in Community Health Centers: CARES Pragmatic Cluster Randomized Clinical Trial
Mailed outreach improved colorectal cancer screening in community health centers, with FIT-DNA outperforming FIT. However, colonoscopy follow-up after abnormal stool tests remained low despite navigation support.
Strengthening the Respiratory Shield: A Critical Review of the US Air Quality Index and Future Research Prioritization
This review synthesizes the American Thoracic Society’s 2026 research statement on the US Air Quality Index, identifying critical knowledge gaps and prioritizing five research domains to enhance its effectiveness for patients with respirato
A Clinically Relevant Threshold of Impaired Contrast Sensitivity Among Older US Adults
A large U.S. study found that a contrast sensitivity score of 1.60 logCS marks the point where older adults are more likely to experience everyday vision disability, even when standard visual acuity may seem acceptable.
Midlife Central Obesity Tracks With Higher Late-Life Plasma P-tau217 and Biomarker-Verified Alzheimer Dementia, While the Association Reverses in Old Age
In the HUNT Study, higher midlife waist-to-height ratio and BMI predicted higher late-life plasma p-tau217 and biomarker-verified Alzheimer dementia, whereas higher adiposity in late life was associated with lower biomarker levels and lower
Interleukin 6 as a Treatment Target for Depression: A Proof-of-Concept Randomized Clinical Trial
A small randomized trial found that blocking IL-6 with tocilizumab showed promising, clinically meaningful trends for inflammation-related, hard-to-treat depression, especially for somatic symptoms, fatigue, anxiety, and quality of life, th
Patient Preference Phenotypes for Post-operative Anticoagulation After Hip or Knee Replacement
A survey study found three distinct patient preference patterns for anticoagulation after hip or knee replacement: clot-prevention focused, balanced, and cost-focused. These differences may help personalize postoperative blood thinner choic
Patient Preference Phenotypes for Post-operative Anticoagulation After Hip or Knee Replacement: A Cross-sectional Survey Study
A survey study found three distinct patient preference patterns for anticoagulation after hip or knee replacement, highlighting the importance of shared decision-making based on clot risk, bleeding risk, and cost.
Regulatory Framework for Private Equity and Corporatization in Health Care: An ACP Position Paper
ACP warns that private equity in health care can raise costs, weaken clinical autonomy, and affect access and quality, calling for stronger transparency, oversight, and protections for physicians and patients.
Exercise May Be a Disease-Modifying Strategy in Chronic Pancreatitis
A new multimodal study links regular physical activity to lower chronic pancreatitis risk and identifies muscle-derived extracellular vesicles as a plausible mechanism limiting pancreatic inflammation, fibrosis, and ferroptosis.
Genome-First Data Suggest Familial Hypercholesterolemia Is Equally Prevalent Across African and European Ancestry Groups, but Underclassified in African Ancestry Patients
A large multi-cohort genome-first study found similar prevalence of pathogenic FH variants across ancestries, but more VUSs and greater LDL-C and myocardial infarction risk among African ancestry individuals, highlighting likely underclassi
Polygenic Scores Often Rival Recurrent CNVs for Psychiatric Risk Stratification, but Both Add Clinical Insight
A large Danish genetic study suggests recurrent CNVs and polygenic scores provide complementary psychiatric risk information, with polygenic scores often identifying more at-risk individuals and potentially modifying CNV-associated risk.
VA Health Professions Trainees Were Disrupted by COVID-19 but Became Meaningful Contributors to Clinical Care, Telehealth, and System Response
A qualitative VA study found that COVID-19 reduced trainee learning opportunities and heightened safety concerns, yet trainees contributed substantially to care delivery, telehealth expansion, patient support, and local pandemic planning.
Medicare Advantage Enforcement Has Been Inconsistent and Financially Modest Despite Expanding Federal Exposure
A 2010-2023 analysis found that CMS enforcement against Medicare Advantage plans was highly variable, usually limited to modest monetary penalties, and more common among lower-rated contracts serving more socially vulnerable beneficiaries.
EBMT Crosses One Million Transplants as Allogeneic HCT and CAR-T Reach New Highs in European Cellular Therapy
The 2024 EBMT activity report marks a major cellular therapy milestone, showing record allogeneic HCT, continued CAR-T expansion, and persistent disparities in donor use, pediatric activity, and country-level access.
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