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When Shift Hours Add Up: Emergency Department Medication Errors Rise as Clinicians Get Tired
Pharmacy interventions on ED medication orders increased as clinicians spent more time on shift. The association persisted across roles and shift types, suggesting fatigue-related risks but varying by site.
Why an EHR-Embedded OUD Intervention Still Struggled: Lessons from 12 Colorado Hospitals
A qualitative study across 12 Colorado hospitals found that an EHR-embedded OUD intervention improved awareness but still faced stigma, inconsistent messaging, limited addiction expertise, and workflow barriers to MOUD initiation.
Updated COVID-19 Vaccination and Cardiovascular Protection: What a Large VA Study Found in 2024-2025
In over 1 million US veterans, the 2024-2025 COVID-19 vaccine was associated with fewer COVID-19-related cardiovascular events, with the strongest benefit in adults over 75 and those with comorbidities.
Can Prehabilitation Reduce Complications After Spinal Fusion in Older Adults? What a New Randomized Trial Suggests
A multicenter randomized trial found that 4-week multimodal prehabilitation added to ERAS reduced 90-day complications after spinal fusion in adults aged 75 years or older.
Validated Early Detection Metrics Could Narrow Liver Fibrosis Screening Without Losing Clinical Signal
A validation study suggests current liver fibrosis screening criteria are too broad. A refined risk-based approach reduced eligibility from 60–76% to 10–22% of adults while improving the yield of elevated liver stiffness and predicting futu
Brain Imaging Biomarkers and Cognitive Outcomes in a Multidomain Lifestyle Intervention: The POINTER Imaging Ancillary Study
The POINTER Imaging study found no overall brain biomarker changes from a structured lifestyle intervention, but participants with lower baseline hippocampal volume showed greater cognitive benefit, suggesting imaging may help identify who
Time-Restricted Eating vs Dietetic Guidance for Glycaemic Outcomes in Adults at Risk of Type 2 Diabetes
Time-restricted eating performed similarly to individualized dietetic guidance for short-term HbA1c change in adults at risk of type 2 diabetes, but non-inferiority was not confirmed at 12 months. Benefits were small, and adverse events wer
Publicly Funded Intermittently Scanned Continuous Glucose Monitoring Is Linked to Fewer Hospitalizations in Insulin-Treated Type 2 Diabetes
A large real-world study found that public implementation of intermittently scanned continuous glucose monitoring in insulin-treated type 2 diabetes was linked to better HbA1c, fewer acute diabetes hospitalizations, shorter stays, and lower
Earlier ADHD Diagnosis May Mark a Better Educational Trajectory: What a Finnish Registry Study Found
In a nationwide Finnish cohort, earlier ADHD diagnosis was linked to better school performance, more academic progression, and less dropout than diagnosis closer to age 16, especially before educational track selection.
Prompt and Intensive Antiviral Chemoprophylaxis in Nursing Home Influenza Outbreaks: Evidence Synthesis and Clinical Implications
Intensive oseltamivir chemoprophylaxis for ≥70% of nursing home residents within 2 days of influenza outbreak reduces hospitalization risk, underscoring prompt antiviral intervention as a critical outbreak control strategy.
Pregnancy in Women With Vascular Malformations Carries High Risks of Postpartum Hemorrhage and Symptom Worsening, While Thromboembolism Clusters in Extensive Lower-Extremity Disease
A nationwide Dutch study suggests pregnancy in women with peripheral vascular malformations is frequently complicated by symptom progression and postpartum hemorrhage, with venous thromboembolism concentrated in extensive lower-extremity ma
Low-Level Airborne Particulate Matter and Risk of Hypertension Hospitalization in Older U.S. Adults
A large U.S. study found that even PM2.5 levels below current federal standards were linked to higher hypertension hospitalization risk in older adults, especially among women and some regional and socioeconomic groups.
Low-Level Airborne Particulate Matter and Risk of Hypertension Hospitalization in Older U.S. Adults
Among more than 26 million older U.S. adults, even PM2.5 levels below current standards were linked to higher hypertension hospitalization risk, suggesting no clearly safe low-exposure threshold.
The Prognostic Value of Serum Interleukin-6 Concentrations for 9 Cardiovascular and Mortality Outcomes
Higher blood IL-6 levels were strongly linked to nine cardiovascular and mortality outcomes in nearly 60,000 adults, supporting IL-6 as an important inflammatory marker and potential prevention target.
Food Delivery After Heart Failure Hospitalization Was Feasible but Did Not Reduce 90-Day HF Readmissions
A randomized trial found that medically tailored meals and fresh produce were highly feasible after HF hospitalization, but neither strategy improved the primary 90-day heart failure utilization outcome versus usual care.
Impact of Population-Based Pathogenic Variant Testing on Risk-Based Breast Screening Recommendations
Population-based testing for breast cancer pathogenic variants identified many women who would not have been flagged by clinical or polygenic risk models, supporting its role in risk-based screening.
A Genome-First Study of Familial Hypercholesterolemia in African and European Ancestry Individuals
A genome-first study found similar rates of pathogenic FH variants in African and European ancestry groups, but uncertain variants were more common and potentially more harmful in African ancestry individuals, highlighting the need for more
Cold Weather Triggers Acute Heart Failure Decompensation, but Hemodynamic Phenotypes Show Opposite Temperature Risks
A large Tokyo case-crossover study found that short-term exposure to low ambient temperature increases acute heart failure admissions, especially in older adults, while patients with hypotensive presentations may be more vulnerable to heat.
Sex-Based Patterns and Trends in Transcatheter Aortic Valve Implantation
A nationwide Medicare study found that women made up a declining share of TAVI patients, had more periprocedural complications, but slightly better long-term survival than men. The findings support sex-specific planning and follow-up in aor
Brazil’s Maternal Mortality Ratio May Be Substantially Higher Than Official Reports Because of Death Certificate Coding Errors
A national Brazilian analysis found 3,480 maternal deaths were missed by official coding from 2010 to 2021, raising the median maternal mortality ratio from 58.2 to 67.5 per 100,000 live births.
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