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Myeloid cell CD36 deficiency reduces hepatic fibrosis by preventing macrophage ferroptosis and restoring antigen presentation, thereby enhancing CD8+ T cell-mediated adaptive immunity. This identifies CD36 as a promising therapeutic target
Elafibranor demonstrates significant efficacy and safety in normalizing alkaline phosphatase among PBC patients inadequately responding to UDCA, establishing ALP normalization as a treatment goal and supporting its role as a second-line the
A new nurse practitioner (NP)-led referral model dramatically accelerates specialist care for patients at risk of advanced liver fibrosis, cutting wai
The AASLD EXPO gives timely, consensus-driven guidance: screen all HBsAg-positive persons once for anti-HDV, confirm viremia with HDV RNA, stage with elastography, and treat compensated chronic HDV with bulevirtide (± peg‑IFN) while monitor
VEGFA and EGF polymorphisms differentially affect cholangiocarcinoma susceptibility and postoperative survival, highlighting their potential as biomarkers for clinical stratification.
This study reveals how age and sex modulate liver transcriptomic responses to statin therapy in metabolic dysfunction-associated steatotic liver disease (MASLD), highlighting statins’ potential to suppress liver aging by targeting sen
Plozasiran, targeting APOC3 mRNA, significantly lowers triglyceride levels and reduces acute pancreatitis incidence in severe hypertriglyceridemia patients, according to pooled data from two placebo-controlled trials.
Metabolic bariatric surgery induces significant histologic regression of cirrhosis and fibrosis remodeling in patients with compensated metabolic dysfunction-associated steatohepatitis (MASH) cirrhosis, challenging the notion that cirrhosis
Aripiprazole, an atypical antipsychotic, shows promising chemopreventive effects against hepatocellular carcinoma (HCC) via antifibrotic, anti-inflammatory, and tumor-suppressive mechanisms involving liver fibroblasts, macrophages, and canc
The NICHE-2 trial demonstrates that neoadjuvant immunotherapy with ipilimumab and nivolumab yields 100% three-year disease-free and five-year overall survival in mismatch repair-deficient colon cancer patients, marking a potential new stand
This review synthesizes current pediatric data on dupilumab for eosinophilic esophagitis, highlighting high remission rates, treatment deescalation, and safety, supported by mechanistic and clinical trial evidence.
MRI-based biomarkers offer non-invasive, precise tools for diagnosing, risk stratifying, and monitoring treatment response in MASLD, potentially transforming patient management and clinical trial endpoints.
This study evaluates different machine preservation strategies in donation after circulatory death (DCD) liver transplantation, highlighting their impact on graft outcomes, particularly nonanastomotic biliary strictures and survival rates,
B-BEST, a novel single-cell RNA sequencing technique, reveals heterogeneity in HBV-infected hepatocytes, linking viral replication states to host cellular pathways, inflammation, and antiviral responses, with implications for precision HBV
In hospitalized patients with cirrhosis awaiting liver transplant, the AM-PAC “6-Clicks” Basic Mobility Score correlates strongly with both pretransplant waitlist mortality and posttransplant survival, offering a practical risk
This national cohort study reveals that intravenous albumin administration after outpatient paracentesis significantly reduces hospitalization rates for acute kidney injury, especially in cirrhotic patients with impaired renal function.
The LITMUS study evaluates non-invasive biomarkers for diagnosing metabolic dysfunction-associated steatotic liver disease, highlighting proteomic panels’ promise in detecting at-risk steatohepatitis and fibrosis stages, potentially r
This study reveals that elevated transglutaminase 2 activity from intestinal myofibroblasts drives fibrosis independent of inflammation in stricturing Crohn’s disease and that inhibiting TG2 can reduce fibrotic ECM accumulation, suggesting
MASLD has become a leading cause of liver transplantation in the US, with increasing transplant volumes and younger recipients. Despite relative stabilization in growth, survival post-transplant has improved, highlighting evolving epidemiol
This study develops and prospectively validates a simple endoscopic classification of fundoplication integrity that reliably predicts pathological gastroesophageal reflux post-antireflux surgery, correlating with functional and clinical out
