Gastroenterology
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Immune Checkpoint Inhibitors Deliver Durable Responses in MSI-H Gastroesophageal Adenocarcinoma
MSI-H/dMMR gastroesophageal adenocarcinoma showed high response rates to immune checkpoint inhibitors, including durable complete responses in locoregional disease that may support carefully selected nonoperative management.
Checkpoint Blockade Delivers Deep, Durable Responses in MSI-H Gastroesophageal Adenocarcinoma
This single-center cohort found high and durable checkpoint inhibitor responses in dMMR/MSI-H gastroesophageal adenocarcinoma, including complete responses in locoregional disease that may support carefully selected nonoperative management.
Lower-Dose Vitamin E Works as Well as Higher Doses in MASLD, VEDS Trial Finds
In adults with suspected MASH, 200 IU/day vitamin E lowered ALT as effectively as 400 IU/day and 800 IU/day over 24 weeks, with no short-term safety signal, supporting lower-dose use if vitamin E is chosen.
SPP1-Positive Macrophages Shape Immunosuppression in Colorectal Cancer Lymph Nodes
Single-cell profiling of colorectal cancer lymph nodes revealed an SPP1–CD44–NF-κB1 pathway that promotes CD137+ regulatory T-cell maturation and may be therapeutically targetable.
Validated Early Detection Metrics Could Narrow Liver Fibrosis Screening Without Losing Clinical Signal
A validation study suggests current liver fibrosis screening criteria are too broad. A refined risk-based approach reduced eligibility from 60–76% to 10–22% of adults while improving the yield of elevated liver stiffness and predicting futu
Post-infection Gut-Brain Disorders Affect About 1 in 10 People With DGBI Worldwide, With Distinct Psychological and Regional Patterns
A large 26-country survey found that post-infection disorders of gut-brain interaction account for 10.5% of DGBI cases and are linked to younger age, male sex, urban living, anxiety, and greater somatic symptom burden.
PRDM9 Deficiency Identifies a Predominant Molecular Subgroup in Sporadic Hirschsprung Disease and Enables Blood-based Risk Stratification
A 2026 Gastroenterology study links PRDM9 deficiency to ectopic DNA breaks, mosaic promoter deletions, and impaired enteric neuronal differentiation in sporadic Hirschsprung disease, while introducing a blood-based molecular score that impr
Role of Relaxing Lateral Incisions as an Add-On to Difficult Hiatal Repair in Redo and Giant Hernia Cases
Lateral relaxing diaphragmatic incisions may help reduce tension during difficult hiatal hernia repairs, improving symptom control in redo and giant hernia cases, though long-term recurrence data are still needed.
Intraperitoneal and Intravenous Paclitaxel Plus S-1 for Gastric Cancer With Peritoneal Metastasis: Phase 3 Trial
A phase 3 trial found that adding intraperitoneal paclitaxel to intravenous paclitaxel plus S-1 improved survival in gastric cancer with peritoneal metastasis without increasing severe toxicity.
When a Stomach Bug Doesn’t End: The Hidden Global Burden of Post-Infection Gut Disorders
A major global study shows that some people develop lasting gut-brain disorders after acute gastroenteritis, linking infections to chronic digestive and psychological symptoms.
HBsAg Seroclearance Lowers Hepatocellular Carcinoma Risk Beyond Viral Suppression in Cirrhosis, but Does Not Reduce Hepatic Decompensation
In NA-treated cirrhotic chronic hepatitis B with complete viral suppression, HBsAg seroclearance was linked to lower HCC risk but not lower hepatic decompensation, reinforcing functional cure as a meaningful but incomplete clinical endpoint
Colonic GPR15L Emerges as a Microbiota-Shaping Host-Defense Peptide That Protects Against Experimental Colitis
New data identify GPR15L as an epithelial host-defense peptide that reshapes the colonic microbiota, reduces experimental colitis, and may have therapeutic relevance in inflammatory bowel disease.
An Obesity Subphenotype With Low Endogenous GLP-1 Production Shows Markedly Greater Weight Loss With Tirzepatide
A 2026 study identifies a biologically distinct obesity subphenotype marked by fast gastric emptying, low GLP-1 synthesis, and substantially greater 6-month weight loss with tirzepatide.
Primary vs Specialist Palliative Care in End-Stage Liver Disease: Interpreting the 2026 Cluster Randomized Trial in the Broader Evidence Base
A major 2026 cluster randomized trial shows that palliative care delivered by trained hepatologists is noninferior to specialist palliative care for improving quality of life in end-stage liver disease, supporting scalable integrated models
Chronic Kidney Disease Worsens Short-Term Outcomes in Hospitalized Patients With Cirrhosis Across a Global Cohort
In a large international prospective cohort of hospitalized patients with cirrhosis, chronic kidney disease was common, clustered with metabolic risk, and strongly associated with acute kidney injury, more decompensation, and higher in-hosp
Computer-Aided Detection Increased Adenoma Detection in a Large Pragmatic Cluster Randomized Colonoscopy Study
In a large Veterans Health Administration cluster randomized study, CADe availability increased adenoma detection during colonoscopy without changing withdrawal time or nonadenomatous lesion detection.
RETREAT Score Stratifies Long-Term Hepatocellular Carcinoma Recurrence Risk After Liver Transplantation in Real-World Practice
A single-center validation study shows the RETREAT score reliably predicts long-term HCC recurrence after liver transplantation and identifies patients with markedly different recurrence-free and overall survival trajectories.
Deprescribing Intervention Reduces Proton Pump Inhibitor Use in Primary Care
A large primary care trial found that a combined patient- and GP-focused deprescribing intervention safely reduced long-term proton pump inhibitor use more effectively than usual care or GP-only education.
Adult Liver Transplant Candidate Evaluation: What the New AASLD/AST Guideline Changes
The updated AASLD/AST guideline clarifies how adults should be evaluated for liver transplantation, emphasizing equitable access, multidisciplinary assessment, psychosocial readiness, and structured risk–benefit decision-making.
TNF-α–Driven Immune-Endothelial Injury Emerges as a Therapeutic Target in Severe Acute Pancreatitis
Single-cell analysis of human severe acute pancreatitis identifies TNF-α–induced CD8+ T-cell endothelial injury as a driver of pancreatic microcirculatory failure, supporting TNF-α blockade as a potential targeted therapy.
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