Internal Medicine
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Allogeneic Stem Cell Transplantation After 70: Japanese Registry Data Define Who May Benefit Most
A Japanese registry study of 929 patients aged 70+ identified six predictors of worse survival after allo-HSCT and created a simple score that sharply stratified 2-year overall survival from 57.1% to 2.5%.
Lower-Dose Vitamin E Works as Well as Higher Doses in MASLD, VEDS Trial Finds
In adults with suspected MASH, 200 IU/day vitamin E lowered ALT as effectively as 400 IU/day and 800 IU/day over 24 weeks, with no short-term safety signal, supporting lower-dose use if vitamin E is chosen.
Galectin-3 Regulates Smooth Muscle Contraction and Blood Pressure by Modulating CaV1.2 Channel Function
Researchers found that Galectin-3 boosts CaV1.2 calcium channel activity in blood vessel muscle, increasing contraction and blood pressure. Blocking this interaction lowered blood pressure in animal models, suggesting a new target for hyper
Mitochondrial Rescue in HFpEF: Elamipretide Restores Skeletal Muscle Performance in a Rat Model
Elamipretide improved skeletal muscle force, titin phosphorylation, and atrophy in a HFpEF rat model, supporting cardiolipin stabilization as a promising mitochondrial-targeted strategy.
Can a Mitochondrial “Membrane Stabilizer” Restore Muscle Function in HFpEF? New Rat Data on Elamipretide
In a HFpEF rat model, elamipretide improved skeletal muscle force, reduced titin hyperphosphorylation, and prevented atrophy, supporting cardiolipin stabilization as a promising metabolic strategy.
When Language Becomes a Safety Risk: English Proficiency and Hospital Restraint Practices
A large single-center study found that hospitalized patients with limited English proficiency had higher adjusted odds of physical restraint or antipsychotic use, especially when delirium was present, raising concerns about communication-dr
Oral NLRP3 Inhibition With Ruvonoflast Produces Rapid, Reversible Suppression of Residual Inflammation in Adults at High Cardiovascular Risk
In a Phase 1b placebo-controlled trial, ruvonoflast markedly reduced hsCRP, IL-6, and fibrinogen over 28 days in adults with obesity, elevated hsCRP, and cardiometabolic risk, supporting further evaluation of oral NLRP3 inhibition in athero
Arrhythmia Burden and Clinical Responses Under Continuous Monitoring in Heart Failure: Observations From the ALLEVIATE-HF Trial
Continuous ICM monitoring in heart failure uncovered a high arrhythmia burden, including atrial fibrillation, bradyarrhythmia, and VT/VF, which was linked to more interventions, hospitalizations, and heart failure events.
More ANOCA Endotypes, More Angina: Comprehensive Coronary Function Testing Reveals a Graded Symptom Burden
In patients with ANOCA, overlapping coronary endotypes were common, and each additional abnormality identified on comprehensive coronary function testing was associated with significantly worse angina burden.
SRPK3-Driven TPM1 Splicing Emerges as a Myofilament Mechanism of Diastolic Dysfunction in HFpEF
A Circulation study identifies SRPK3-mediated alternative splicing of TPM1 exon 9a as a driver of myofibrillar disarray, reduced myocardial compliance, and diastolic dysfunction in HFpEF, highlighting a potential disease-modifying therapeut
Primary vs Specialist Palliative Care in End-Stage Liver Disease: Interpreting the 2026 Cluster Randomized Trial in the Broader Evidence Base
A major 2026 cluster randomized trial shows that palliative care delivered by trained hepatologists is noninferior to specialist palliative care for improving quality of life in end-stage liver disease, supporting scalable integrated models
Point-of-Care Ultrasound in Acute Care Did More Than Diagnose: It Reassured Patients, Reduced Burden, and Deepened Trust
A qualitative study found that patients experienced point-of-care ultrasound as emotionally reassuring, physically convenient, and closely tied to physician communication and trust during acute care.
Higher Oral Corticosteroid Exposure in Chronic Rhinosinusitis With Nasal Polyps Is Linked to More Systemic Harm
A nationwide Korean nested case-control study found that longer annual duration and higher cumulative oral corticosteroid dose in chronic rhinosinusitis with nasal polyps were associated with increased systemic adverse events, supporting st
Routine Hospitalist Co-Management After Head and Neck Free Flap Surgery Was Linked to Fewer Escalations of Care, but Not Shorter Stay or Lower Mortality
In a retrospective cohort of 362 head and neck free tissue transfer patients, routine hospitalist involvement was associated with fewer transfers to a higher level of care, without significant effects on length of stay, readmission, or 90-d
Acetazolamide Fails to Improve Gait in Idiopathic Normal Pressure Hydrocephalus: Swedish DRAIN Trial
In a Swedish randomized trial, low-dose acetazolamide did not improve gait in patients with idiopathic normal pressure hydrocephalus and caused more side effects than placebo, arguing against routine use as medical therapy.
Enteral vs IV Magnesium Replacement in Critically Ill Patients: A Randomized Noninferiority Trial
A randomized ICU trial found oral/enteral magnesium was not proven noninferior to IV replacement for correcting mild-to-moderate hypomagnesemia, but it lowered urinary magnesium loss, cost, waste, carbon emissions, and IV fluid use.
One in Six Older Emergency Department Patients Has Delirium: New Multisite Data Highlight Missed Risk, Mixed Management, and Higher Hospital Use
A large multisite cohort found delirium in 16% of older adults in the emergency department, including nearly 8% of those discharged, with strong links to dementia, acuity, hospitalization, and 30-day readmission.
One in Six Older Adults Presenting to the Emergency Department Had Delirium, With Higher Admission and 30-Day Readmission Risk
A large multi-site cohort found delirium in 16% of older ED patients, including many discharged home, and linked it to higher admission and 30-day readmission, underscoring the need for standardized screening and supportive care.
Bempedoic Acid Was Linked to Fewer Venous Thromboembolic Events in Statin-Intolerant Patients in CLEAR Outcomes
In a post hoc analysis of CLEAR Outcomes, bempedoic acid was associated with a significantly lower risk of venous thromboembolism, including deep vein thrombosis and pulmonary embolism, among statin-intolerant patients at high cardiovascula
Arrhythmia Burden and Clinical Responses Under Continuous Monitoring in Heart Failure: Observations From the ALLEVIATE-HF Trial
Continuous ICM monitoring in heart failure found a high burden of atrial fibrillation, bradyarrhythmia, and VT/VF. Arrhythmias were linked to more interventions and higher hospitalization risk, but the congestion-management strategy did not
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