Internal Medicine
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甲状腺功能随年龄变化的自然历程：一项涵盖31项前瞻性队列研究的13.7万参与者个体数据分析
大规模国际研究发现甲状腺功能随年龄变化存在性别和碘状态差异。虽然多数人甲状腺功能稳定且TSH轻微升高，但任何变化模式均与全因死亡风险增加1.8-2.5倍相关，这对老年甲状腺健康管理具有重要临床意义。
Targeting Skeletal Muscle Myosin ATPase May Reduce Resting Energy Waste in Heart Failure With Reduced Ejection Fraction
An ex vivo human skeletal muscle study suggests that myosin ATPase inhibition with mavacamten normalizes excessive resting ATP consumption in HFrEF myofibres, identifying a mechanistically novel strategy to address peripheral metabolic inef
Long-Term SAFE-PAD Data Reassure on Mortality After Paclitaxel-Coated Femoropopliteal Interventions
In Medicare patients undergoing femoropopliteal revascularization, drug-coated devices were not associated with higher long-term mortality, supporting the safety of paclitaxel-coated technology after years of regulatory concern.
PCSK9 Inhibition Lowers LDL Cholesterol in Heterozygous Familial Hypercholesterolemia Regardless of LDL Receptor Variant Function
In a pooled nonrandomized phase 3 analysis, monthly lerodalcibep reduced LDL-C by about 50% in heterozygous familial hypercholesterolemia, with similar efficacy across LDLR functional variant categories and broad attainment of guideline-bas
HSP72-PRDX6 Control of PINK1 Ubiquitination Emerges as a New Mitophagy Axis in MASLD
A new Hepatology study identifies an HSP72–PRDX6 pathway that restores PINK1/Parkin mitophagy, reduces hepatic steatosis, and worsens MASLD when disrupted in mice and hepatocytes.
Fontan Outcomes Network Enrolls 1,121 Patients and Reveals a High Burden of Arrhythmia, Thrombosis, and Mental Health Needs
Background Fontan palliation has transformed the prognosis of children born with single-ventricle heart disease, allowing...
Midlife Cardiorespiratory Fitness Linked to Extended Healthspan and Reduced Multimorbidity in Aging
Higher midlife cardiorespiratory fitness is associated with longer healthspan, fewer chronic diseases, and extended lifespan in men and women, based on a large observational cohort study linking clinical data to Medicare claims.
Chronic Low Back Pain: Physical Therapy Outperforms CBT as First-Line Treatment
A recent randomized trial found PT modestly improved function over CBT in cLBP, but no second-stage treatment differences emerged for nonresponders. The study informs adaptive treatment strategies.
Mild and Single Moderate COPD Exacerbations Predict Future Risks: Insights from a Community-Based Cohort Study
Community-based COPD patients with mild or single moderate exacerbations show higher future exacerbation risks and lung structural abnormalities, despite stable lung function decline rates.
Revolutionizing iTTP Treatment: Reverse CAR T Cells Target Autoreactive B Cells with Precision
A groundbreaking study introduces reverse CAR T cells to selectively deplete anti-ADAMTS13 autoreactive B cells in immune-mediated thrombotic thrombocytopenic purpura (iTTP), offering a novel, precise, and potentially safer therapeutic appr
Reevaluating TSH-FT4 Dynamics: New Evidence Challenges Traditional Reference Intervals
A retrospective study reveals that the TSH-FT4 relationship is segmented, not log-linear, with implications for refining thyroid function test interpretation and reference intervals.
Hospital Delays in Glucose Checks and Insulin Dosing: Do They Impact Patient Care?
Study reveals significant time gaps between fingerstick glucose tests and insulin administration in hospitals, with nearly 30% of cases potentially receiving incorrect insulin doses due to changing glucose levels during delays.
Blast-Phase MPNs: One-Third Achieve Long-Term Survival with Allogeneic Transplantation
Allogeneic hematopoietic stem cell transplantation offers a potential cure for blast-phase myeloproliferative neoplasms, with one-third of patients achieving long-term survival. Key factors influencing outcomes include TP53 mutations and pe
Restrictive Thyroid Incidentaloma Guidelines Cut Workload Dramatically but Miss a Small Number of Low-Risk Cancers
Conventional imaging-detected thyroid incidentalomas rarely prove malignant. A retrospective study found restrictive guidelines can sharply reduce unnecessary workup, though a small number of low-risk cancers may be missed.
Genetic Variant in CUBN Gene Identified as Key Risk Factor for Metformin-Induced Vitamin B12 Deficiency
Researchers have identified a genetic variant in the cubilin gene (CUBN, rs1801222) that significantly increases the risk of metformin-induced vitamin B12 deficiency, with carriers of the AA genotype experiencing deficiency up to twice as f
Fluvoxamine Shows Promise for Treating Long COVID Fatigue: Results from Adaptive Randomized Trial
A randomized trial of 399 adults with long COVID fatigue found that fluvoxamine significantly reduced fatigue severity at 60 and 90 days compared to placebo, while metformin showed no benefit. The study represents a potential breakthrough i
Cardiologist Evaluation After Postoperative Myocardial Injury Was Linked to Better 1-Year Outcomes
Post-operative cardiologist evaluation after peri-operative myocardial injury was associated with fewer major cardiac events and lower 1-year mortality in high-risk non-cardiac surgery patients.
Nerandomilast in Idiopathic Pulmonary Fibrosis: Long-Term Insights from the FIBRONEER-IPF Trial
An in-depth analysis of the FIBRONEER-IPF trial’s extended follow-up data, evaluating the efficacy and safety of the PDE4B inhibitor nerandomilast in reducing clinical events and mortality in patients with idiopathic pulmonary fibrosis.
Mind the Gap: Why Point-of-Care and Central Lab Electrolytes Are Not Interchangeable in the ICU
A prospective study highlights significant discrepancies between point-of-care and central laboratory sodium and potassium measurements in the ICU, revealing a 10.48 mmol/L limit of agreement for sodium and a widespread lack of physician aw
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