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This 7-year longitudinal study using HR-pQCT reveals that seropositive rheumatoid arthritis patients experience greater trabecular bone deterioration versus psoriatic arthritis, with sustained remission preserving bone integrity across infl
Wearable devices offer continuous, real-world data to enhance frailty assessments beyond conventional episodic clinical measures. Combining this data with the Hospital Frailty Risk Score (HFRS) facilitates earlier detection and intervention
This study investigates how decisions made by patients versus surrogates affect the intensity of end-of-life care and hospitalization costs in ICU settings, revealing that surrogate decisions often lead to higher care intensity and costs, p
This study assesses health and care satisfaction outcomes in younger disabled adults enrolled in a Program of All-Inclusive Care for the Elderly (PACE), highlighting functional and community engagement trends, satisfaction, and healthcare u
This cluster-randomized trial demonstrates that biannual topical 38% silver diamine fluoride is noninferior to atraumatic restorative treatments for arresting and preventing dental caries in older adults, providing a simple, effective strat
This study reveals how age and sex modulate liver transcriptomic responses to statin therapy in metabolic dysfunction-associated steatotic liver disease (MASLD), highlighting statins’ potential to suppress liver aging by targeting sen
This article explores how the autotaxin/lysophosphatidic acid axis regulates macrophage-driven osteoclastogenesis and inflammation in periodontitis, highlighting the therapeutic potential of autotaxin inhibitors to prevent alveolar bone res
Serum periostin measured one year after lung transplantation correlates with subsequent chronic lung allograft dysfunction, offering a promising biomarker for early risk stratification.
Participation in a structured behavioral health training program among primary care providers is linked to significantly lower mental health stigma, suggesting education as a key strategy to improve equitable mental health care.
This study reveals that HFE gene variants can be associated with arthropathy meeting EULAR haemochromatosis arthropathy criteria, even in the absence of iron overload or classical genetic haemochromatosis, suggesting an iron-independent pat
Serial monitoring of donor-derived cell-free DNA during the first 4 months post-kidney transplantation reveals distinct risk profiles for rejection, graft dysfunction, and loss, enabling early stratification and potentially guiding personal
Higher ICU patient volume for severely ill patients, as stratified by SOFA scores, is linked to lower in-hospital mortality, with the effect more pronounced at greater illness severity.
A concise, clinician-focused review of the AAOS 2024 carpal tunnel syndrome guideline: streamlined diagnosis, evidence-based nonoperative care, and indications for timely referral and surgery.
Delirium in hospitalized, cognitively normal adults significantly increases the risk of future mild cognitive impairment, dementia, and accelerates cognitive decline over years, highlighting the need for vigilant delirium prevention and mon
A Johns Hopkins study found that a comprehensive Chronic Care Management program significantly reduced hospitalizations, emergency visits, and acute care costs among high-risk patients, demonstrating the value of coordinated multidisciplina
In hospitalized patients with cirrhosis awaiting liver transplant, the AM-PAC “6-Clicks” Basic Mobility Score correlates strongly with both pretransplant waitlist mortality and posttransplant survival, offering a practical risk
Admission dysphagia screening using a nurse-led protocol was associated with a significant reduction in hospital-acquired aspiration pneumonia among general ward patients, highlighting its role in preventative hospital care.
In patients with suspected obstructive sleep apnea, increased respiratory effort measured by negative esophageal pressure during sleep independently predicts long-term mortality beyond traditional markers, underscoring its clinical importan
The LITMUS study evaluates non-invasive biomarkers for diagnosing metabolic dysfunction-associated steatotic liver disease, highlighting proteomic panels’ promise in detecting at-risk steatohepatitis and fibrosis stages, potentially r
A machine learning model using common blood tests, age, sex, and smoking status moderately distinguishes severe from mild periodontitis, highlighting potential but necessitating further validation before clinical use.
