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Higher PFAS Exposure During Pregnancy Was Not Linked to Increased Gestational Diabetes in the ECHO Cohort
In a pooled U.S. pregnancy cohort, maternal PFAS concentrations were not associated with a higher prevalence of gestational diabetes, and fasting glucose findings were largely null.
甲状腺功能随年龄变化的自然历程：一项涵盖31项前瞻性队列研究的13.7万参与者个体数据分析
大规模国际研究发现甲状腺功能随年龄变化存在性别和碘状态差异。虽然多数人甲状腺功能稳定且TSH轻微升高，但任何变化模式均与全因死亡风险增加1.8-2.5倍相关，这对老年甲状腺健康管理具有重要临床意义。
Targeting Skeletal Muscle Myosin ATPase May Reduce Resting Energy Waste in Heart Failure With Reduced Ejection Fraction
An ex vivo human skeletal muscle study suggests that myosin ATPase inhibition with mavacamten normalizes excessive resting ATP consumption in HFrEF myofibres, identifying a mechanistically novel strategy to address peripheral metabolic inef
AI-ECG Identified Left Ventricular Systolic Dysfunction in Kenya With High Sensitivity and Excellent Rule-Out Performance
In Kenyan outpatient clinics, an AI-enabled ECG algorithm showed strong discrimination for left ventricular systolic dysfunction, with 95.6% sensitivity and 99.1% negative predictive value against echocardiography.
Long-Term SAFE-PAD Data Reassure on Mortality After Paclitaxel-Coated Femoropopliteal Interventions
In Medicare patients undergoing femoropopliteal revascularization, drug-coated devices were not associated with higher long-term mortality, supporting the safety of paclitaxel-coated technology after years of regulatory concern.
A New Pediatric VAD Driver Shows High Reliability and Preserves Mobility Without Major Device Malfunctions
In a prospective multicenter evaluation, the EXCOR Active Driver supported pediatric VAD care with no major device malfunctions and excellent short-term survival, while addressing a major unmet need in mobility and day-to-day function.
Wider Cranial Arteries, Not Atherosclerotic Stenosis, Track With Lacunar Stroke and Cerebral Small-Vessel Disease
In a prospective mild stroke cohort, cranial arterial dolichoectasia and larger intracranial arterial diameters were linked to lacunar stroke, cSVD burden, and incident infarcts, whereas large-artery stenosis was not.
Epigenetic Regulation of Myocardial Inflammation: The Role of Macrophage PRMT9 and STAT1 Degradation in Acute Myocardial Infarction
This review explores how PRMT9-mediated symmetric dimethylation of STAT1 serves as a critical check on proinflammatory macrophage activation, offering a novel therapeutic target for mitigating cardiac injury following myocardial infarction.
Semaglutide Reduced Effort Discounting and Improved Motivation Signals in Major Depressive Disorder
In a 16-week randomized trial, adjunctive oral semaglutide improved effort-based decision-making in adults with major depressive disorder and overweight or obesity, suggesting a potential role for GLP-1 receptor agonism in reward-related dy
Continuous Subphenotype Probabilities Expose High-Risk Patients Hidden Within “Hypoinflammatory” Acute Respiratory Failure
AHRF patients classified as hypoinflammatory are not prognostically uniform. Continuous biomarker-based probabilities reveal substantial mortality heterogeneity, especially below the binary 0.5 threshold, with implications for enrichment st
Earlier Mechanical Thrombectomy for Intermediate-Risk Pulmonary Embolism Improves Hemodynamics but Not In-Hospital Mortality
In a multicenter retrospective study, early mechanical thrombectomy within 12 hours of pulmonary embolism diagnosis improved pulmonary artery pressure reduction and reduced intubation, but did not significantly lower in-hospital mortality.
Ambient AI Scribes Reduced Emergency Department Documentation Time, but Early Adoption Was Limited and Highly Concentrated
In a real-world academic emergency department, ambient AI scribe use was uncommon and concentrated among a small group of physicians, but when used it was associated with shorter documentation and total EHR time.
Education and Neighborhood Resources Explain Much of the Racial and Ethnic Gap in Timely Dementia Diagnosis
Among older U.S. adults with dementia, non-Hispanic Black and Hispanic individuals were significantly less likely than non-Hispanic White individuals to receive a timely diagnosis, with education and neighborhood affluence explaining much o
Medicare’s Oncology Care Model Did Not Increase Systemic Therapy Starts and Was Linked to Lower Use in Poor-Prognosis Cancer
A matched difference-in-differences study found that the Oncology Care Model did not increase systemic therapy initiation overall and was associated with lower treatment initiation and lower spending in poor-prognosis cancers.
“Never More Than 15 Feet From the Respirator”: Housestaff Research During the 1955 Boston Polio Epidemic
During Boston’s devastating 1955 polio epidemic, Massachusetts General Hospital trainees conducted groundbreaking patient research while providing round-the-clock care in iron lung wards – a striking contrast to trainee roles during COVID-1
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