OB/GYN & Women’s Health
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Tumor Morcellation, Not Minimally Invasive Surgery Alone, Drives Worse Disease-Free Survival in Stage I Adult Granulosa Cell and Sertoli-Leydig Cell Tumors
In stage I ovarian sex cord-stromal tumors, stage IC and tumor morcellation were independently associated with recurrence, while minimally invasive surgery itself was not after adjustment.
Phenotyping Preeclampsia Using Unsupervised Machine Learning: A Prospective Cohort Study
Unsupervised machine learning identified three distinct preeclampsia phenotypes linked to timing of delivery, placental dysfunction, fetal growth, and complications, suggesting a path toward more personalized risk assessment and management.
Severe Maternal Morbidity at Delivery Is Linked to Shorter and Less Exclusive Breastfeeding in Nulliparous U.S. Patients
In a large prospective U.S. cohort, severe maternal morbidity did not reduce breastfeeding initiation, but it was associated with lower odds of breastfeeding beyond 6 months and of exclusive breastfeeding.
Pregnancy Complications Signal Long-Term Maternal Risk of Subarachnoid Hemorrhage in a 50-Year Swedish Cohort
In a nationwide Swedish cohort, several adverse pregnancy outcomes were linked to higher long-term maternal risk of subarachnoid hemorrhage, supporting pregnancy as an early vascular stress test.
Transcriptome Profiling With CCNA2 and E2F1 May Identify Platinum Insensitivity and Refine Prognosis in Endometrial Cancer
TCGA-based transcriptome analysis suggests high CCNA2 and E2F1 expression marks poor progression-free survival and probable platinum insensitivity in endometrial cancer, supporting pretreatment molecular stratification and alternative thera
Long-Term Risk of Hypothyroidism After Thyroid Abnormalities Identified in Pregnancy
Thyroid abnormalities found during pregnancy, especially when subclinical hypothyroidism and TPO antibodies coexist, can signal a much higher long-term risk of overt hypothyroidism, supporting ongoing thyroid follow-up after delivery.
Fovinaciclib for First-Line Therapy of Advanced Breast Cancer: A Randomized Clinical Trial
Adding fovinaciclib to first-line aromatase inhibitor therapy significantly prolonged progression-free survival in hormone receptor-positive, ERBB2-negative advanced breast cancer with manageable toxicity and preserved quality of life.
More Than Half of Patients With Atypical Endometrial Hyperplasia Had Occult Cancer at Hysterectomy in a Minority-Enriched Urban Cohort
A single-center retrospective study found unexpectedly high rates of concurrent endometrial carcinoma and Mayo-criteria risk features among patients with atypical endometrial hyperplasia in a predominantly racial and ethnic minority populat
Postmarketing Data Link Fezolinetant Primarily to Early Transaminase Elevations Rather Than Overt Liver Injury
FAERS postmarketing data suggest fezolinetant is associated with an early hepatic adverse event reporting signal, driven mainly by liver enzyme elevations rather than consistent severe clinical liver injury.
Less Than 5 kg of Gestational Weight Gain in Type 2 Diabetes Was Linked to Lower Risk of LGA, Hypertensive Disorders, NICU Admission, and Cesarean Delivery
In a retrospective cohort of pregnancies complicated by type 2 diabetes, gestational weight gain under 5 kg was associated with lower odds of several adverse perinatal outcomes without a statistically significant rise in preterm birth or sm
Premature Natural Menopause Signals Higher Lifetime Coronary Heart Disease Risk in Both Black and White Women
A pooled US cohort analysis found that natural menopause before age 40 was associated with about a 40% higher lifetime risk of coronary heart disease in both Black and White women, supporting its use as a routine cardiovascular risk-enhanci
Beyond Extrapolation: Immunotherapy Outcomes in Recurrent Vulvovaginal Carcinoma
This retrospective study found that immune checkpoint inhibitors produced modest overall benefit in recurrent vulvar and vaginal carcinoma, but a small subset of patients had durable responses lasting months.
Association Between Surgical Volume and Postoperative Complications After Posterior Deep Infiltrating Endometriosis Surgery: A Nationwide Study
A nationwide French study found that hospitals performing at least 40 posterior deep infiltrating endometriosis surgeries per year had fewer severe postoperative complications, supporting referral to experienced, high-volume centers.
Association Between Delivery Mode and Postpartum Psychiatric Conditions
A large U.S. cohort study found higher rates of postpartum psychiatric conditions after planned or unplanned cesarean delivery, but not after successful operative vaginal delivery, highlighting the need for closer postpartum mental health f
Automated Insulin Delivery Improves Glycemia During Labor and Early Postpartum in Type 1 Diabetes: Clinical Insights From the CIRCUIT Trial
A prespecified CIRCUIT analysis found that Control-IQ closed-loop insulin delivery improved intrapartum time in range and reduced early postpartum hypoglycemia versus standard care in women with type 1 diabetes, without new safety concerns.
Proteinuria in Preeclampsia and Long-Term Risk of Maternal Kidney and Cardiovascular Disease
Higher proteinuria in preeclampsia was linked to greater long-term risk of maternal hypertension and chronic kidney disease, with overall increased risk of cardiovascular disease as well.
Does the order of ablation of vein-to-vein placental connections during fetoscopic laser photocoagulation affect outcomes in twin-twin transfusion syndrome?
In TTTS, a post hoc analysis found that treating vein-to-vein placental connections at the end of fetoscopic laser surgery was linked to worse donor and recipient survival than earlier treatment.
Prepregnancy Insulin Resistance and Fertility Outcomes in Women With PCOS
Higher insulin resistance before pregnancy was linked to poorer ovulation, lower pregnancy and live-birth rates, and more gestational diabetes in women with PCOS. Improving insulin resistance during treatment was associated with better preg
Women with Chronic Coronary Artery Disease: Long-Term Outcomes After PCI vs CABG
In women with chronic severe coronary artery disease, CABG was linked to lower long-term rates of death, stroke, heart attack, repeat revascularization, and cardiovascular readmission than PCI.
Cost-effectiveness of Pembrolizumab for FIGO 2014 Stage III-IVA Cervical Cancer in the United States
Pembrolizumab plus chemoradiotherapy improved survival and quality-adjusted survival for FIGO 2014 stage III-IVA cervical cancer and was projected to be cost-effective in the U.S. at a $150,000/QALY threshold.
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