Cardiology
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Unveiling the Phenotype of Unclassified Pulmonary Hypertension: A Hidden Spectrum of Early Heart Failure with Preserved Ejection Fraction
Unclassified pulmonary hypertension often reflects early-stage HFpEF linked to left heart and metabolic dysfunction, identifiable via dynamic right heart catheterization and metabolomics.
Biomarker, Functional Status, and Quality-of-Life Trajectories Before Modes of Death in Heart Failure: Post Hoc Analysis of the FINEARTS-HF Randomized Clinical Trial
This study reveals that sudden death in heart failure patients often follows gradual clinical decline, challenging the notion that such deaths are always abrupt.
Decoding SLC4A3 Mutations in Short QT Syndrome: Insights from hiPSC-Derived Cardiomyocytes into Ventricular Arrhythmia and Sudden Cardiac Death
This article reviews how SLC4A3 gene mutations cause short QT syndrome by inducing intracellular alkalinization and altered ion channel currents, increasing arrhythmia risk, based on stem cell-derived cardiomyocyte models.
Decade-Long Outcomes of SAPIEN 3 TAVR vs. Surgery in Intermediate-Risk Aortic Stenosis Patients
This analysis reveals comparable 10-year mortality, valve durability, and hemodynamics between SAPIEN 3 transcatheter and surgical aortic valve replacement in intermediate-risk patients, underscoring TAVR’s durable benefit.
High-Dose Vitamin C After Cardiac Arrest: Promise Meets a Negative Signal in VITaCCA
In a multicenter phase 2 trial, early intravenous vitamin C did not improve post-cardiac arrest organ dysfunction and the 10 g dose was associated with worse outcomes, including renal, cardiac, and neurologic signals.
Updated COVID-19 Vaccination and Cardiovascular Protection: What a Large VA Study Found in 2024-2025
In over 1 million US veterans, the 2024-2025 COVID-19 vaccine was associated with fewer COVID-19-related cardiovascular events, with the strongest benefit in adults over 75 and those with comorbidities.
Tirzepatide vs Dulaglutide: New Post Hoc SURPASS-CVOT Data Point to Broader Cardiorenal Benefit
Post hoc SURPASS-CVOT analysis found tirzepatide lowered a broad 6-component cardiorenal composite versus dulaglutide in high-risk patients with type 2 diabetes, with more gastrointestinal adverse events but similar overall safety.
Postoperative Atrial Fibrillation After Cardiac Surgery: Common, Variably Treated, and Linked to Worse 1-Year Outcomes
The VISION Cardiac Surgery cohort found POAF in about one-third of patients, with wide variation in discharge treatment. POAF strongly predicted later atrial fibrillation and was associated with higher 1-year mortality.
10-Year Randomized Outcomes of Transcatheter or Surgical Aortic Valve Replacement in Intermediate-Risk Aortic Stenosis: What PARTNER 2A Adds to the Long-Term TAVR Evidence Base
The PARTNER 2A 10-year data show higher mortality and reintervention with balloon-expandable SAPIEN XT TAVR versus surgery in intermediate-risk patients, driven mainly by transthoracic access. Contemporary 10-year SAPIEN 3 data, however, su
Galectin-3 Regulates Smooth Muscle Contraction and Blood Pressure by Modulating CaV1.2 Channel Function
Researchers found that Galectin-3 boosts CaV1.2 calcium channel activity in blood vessel muscle, increasing contraction and blood pressure. Blocking this interaction lowered blood pressure in animal models, suggesting a new target for hyper
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