Cardiology
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Targeting Skeletal Muscle Myosin ATPase May Reduce Resting Energy Waste in Heart Failure With Reduced Ejection Fraction
An ex vivo human skeletal muscle study suggests that myosin ATPase inhibition with mavacamten normalizes excessive resting ATP consumption in HFrEF myofibres, identifying a mechanistically novel strategy to address peripheral metabolic inef
AI-ECG Identified Left Ventricular Systolic Dysfunction in Kenya With High Sensitivity and Excellent Rule-Out Performance
In Kenyan outpatient clinics, an AI-enabled ECG algorithm showed strong discrimination for left ventricular systolic dysfunction, with 95.6% sensitivity and 99.1% negative predictive value against echocardiography.
Long-Term SAFE-PAD Data Reassure on Mortality After Paclitaxel-Coated Femoropopliteal Interventions
In Medicare patients undergoing femoropopliteal revascularization, drug-coated devices were not associated with higher long-term mortality, supporting the safety of paclitaxel-coated technology after years of regulatory concern.
A New Pediatric VAD Driver Shows High Reliability and Preserves Mobility Without Major Device Malfunctions
In a prospective multicenter evaluation, the EXCOR Active Driver supported pediatric VAD care with no major device malfunctions and excellent short-term survival, while addressing a major unmet need in mobility and day-to-day function.
Earlier Mechanical Thrombectomy for Intermediate-Risk Pulmonary Embolism Improves Hemodynamics but Not In-Hospital Mortality
In a multicenter retrospective study, early mechanical thrombectomy within 12 hours of pulmonary embolism diagnosis improved pulmonary artery pressure reduction and reduced intubation, but did not significantly lower in-hospital mortality.
Pulmonary Arterial Hypertension Therapy Preserves Gas Exchange Overall in Portopulmonary Hypertension, but New Intrapulmonary Vascular Dilatations Can Emerge
In PoPH, PAH-specific therapy did not worsen oxygenation overall, although responses varied widely. Hemodynamic changes influenced gas exchange, and some patients developed new intrapulmonary vascular dilatations during follow-up.
PCSK9 Inhibition Lowers LDL Cholesterol in Heterozygous Familial Hypercholesterolemia Regardless of LDL Receptor Variant Function
In a pooled nonrandomized phase 3 analysis, monthly lerodalcibep reduced LDL-C by about 50% in heterozygous familial hypercholesterolemia, with similar efficacy across LDLR functional variant categories and broad attainment of guideline-bas
Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions
Researchers developed and validated integrated polygenic risk scores for eight cardiovascular conditions using data from over 245,000 individuals. These scores demonstrated strong predictive power and improved risk classification, providing
GLP-1 Receptor Agonists Show Lower Heart Failure Risk Versus DPP-4 Inhibitors in Type 2 Diabetes
New research comparing diabetes medications reveals GLP-1 receptor agonists lower heart failure hospitalization risk compared to DPP-4 inhibitors, while showing similar risk to SGLT-2 inhibitors in type 2 diabetes patients.
Late-Life Stroke in ARIC Was More Often Embolic, and Atrial Disease Explained Much of the Risk
In ARIC, ischemic stroke at age 80 years or older was more often embolic than thrombotic. Atrial fibrillation and left atrial disease explained much of the age effect, and adding embolic factors improved prediction.
ATTR-CM Is Often Diagnosed Years After Heart Failure in Medicare Patients
In Medicare beneficiaries, ATTR-CM was diagnosed a median 494 days after heart failure and 840 days after loop diuretic initiation, with delays more common in women and patients with several common comorbidities.
Standard-Dose DOACs Outperform Warfarin More Strongly in Asian Than Non-Asian Patients With Atrial Fibrillation
In a patient-level meta-analysis of 10,212 Asian and 61,471 non-Asian AF patients, standard-dose DOACs outperformed warfarin more strongly in Asians, with less stroke, major bleeding, and net clinical harm. Standard-dose therapy was favored
Coronary Stent Trial Site Selection Could Narrow Racial Gaps in Enrollment, but Women Remain Underrepresented
In nine U.S. coronary stent PMA trials, minority participants were markedly underrepresented, while women were modestly underrepresented. Site geography and surrounding county demographics predicted minority enrollment, suggesting targeted
Elevated Heart Failure Risk in People With HIV: Insights from the REPRIEVE Trial
The REPRIEVE trial reveals higher heart failure incidence in people with HIV, particularly among women, Black participants in high-income regions, and those with hypertension or obesity. Traditional risk factors, not HIV-specific markers, w
Burst Exercise Testing Outperforms Traditional Bruce Protocol in CPVT Diagnosis and Management
A new study shows that the Burst exercise stress test is more effective than the traditional Bruce protocol in detecting arrhythmias in CPVT patients, leading to better treatment decisions without safety concerns.
Midlife Cardiorespiratory Fitness Linked to Extended Healthspan and Reduced Multimorbidity in Aging
Higher midlife cardiorespiratory fitness is associated with longer healthspan, fewer chronic diseases, and extended lifespan in men and women, based on a large observational cohort study linking clinical data to Medicare claims.
Exploring the Link Between Cardiovascular-Kidney-Metabolic Syndrome and Heart Failure Risk in Older Adults
Higher CKM syndrome stages correlate with adverse cardiac remodeling and increased heart failure risk in older adults, as shown in the ARIC Study.
Prolonged TSH Suppression in Postmenopausal Thyroid Cancer Patients Linked to Worse Cardiovascular and Quality-of-Life Outcomes
Study finds long-term TSH suppression in postmenopausal women with thyroid cancer correlates with poorer cardiovascular health, reduced quality of life, and increased osteoporosis risk compared to controls.
Circulatory Support Escalation in Cardiogenic Shock: Outcomes and Predictors of Success
A multi-center study reveals that circulatory support escalation in cardiogenic shock is associated with higher mortality and complications, but certain patient factors can predict successful outcomes.
RBM20 Truncating Variants in Dilated Cardiomyopathy: Reduced Penetrance and Milder Phenotype Compared to Missense Variants
This study highlights the role of RBM20 truncating variants in arrhythmogenic dilated cardiomyopathy, showing reduced penetrance and milder disease severity compared to pathogenic missense variants and titin truncating variants.
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