Cardiology
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Precardioversion Heart Rhythm Monitoring Using Smartphone Photoplethysmography: The SMARTBEATS Randomized Clinical Trial
Smartphone photoplethysmography before planned cardioversion reduced same-day cancellations in patients with atrial fibrillation or flutter by detecting spontaneous return to sinus rhythm early.
Disrupted MAML1 Phase Separation Emerges as a New Mechanism Linking Notch Failure to Congenital Heart Disease
A Circulation study identifies MAML1 as a candidate congenital heart disease gene and shows that defective phase separation in endocardial cells suppresses Notch signaling, impairing endocardial-to-mesenchymal transition and causing septal
Spontaneous Preterm Birth as a Sentinel for Cardiovascular Mortality: Insights from a National Registry Study
A large-scale Dutch cohort study reveals that women with a history of spontaneous preterm birth face a significantly elevated risk of cardiovascular mortality, with the highest risk observed in those delivering before 32 weeks of gestation.
Precision Prescribing of SGLT2 Inhibitors in Type 2 Diabetes for Primary Prevention of Heart Failure
A validated model, SABRE, estimates who with type 2 diabetes may gain the most heart-failure prevention benefit from SGLT2 inhibitors, enabling more precise, individualized prescribing.
Bempedoic Acid Was Linked to Fewer Venous Thromboembolic Events in Statin-Intolerant Patients in CLEAR Outcomes
In a post hoc analysis of CLEAR Outcomes, bempedoic acid was associated with a significantly lower risk of venous thromboembolism, including deep vein thrombosis and pulmonary embolism, among statin-intolerant patients at high cardiovascula
Thyroid Dysfunction Is a Cardiovascular Risk Multiplier, but Treatment Benefits Depend on Phenotype, Severity, and Age
Thyroid dysfunction reshapes lipid metabolism, vascular tone, cardiac performance, and rhythm. Cardiovascular risk is clearest at the extremes of thyroid status, while treatment decisions in subclinical disease should remain individualized.
Arrhythmia Burden and Clinical Responses Under Continuous Monitoring in Heart Failure: Observations From the ALLEVIATE-HF Trial
Continuous ICM monitoring in heart failure found a high burden of atrial fibrillation, bradyarrhythmia, and VT/VF. Arrhythmias were linked to more interventions and higher hospitalization risk, but the congestion-management strategy did not
Rethinking Magnesium Prophylaxis for Postoperative Atrial Fibrillation in Cardiac Surgery: A Synthesis of Clinical Evidence
Recent high-quality randomized clinical trials and meta-analyses suggest that routine magnesium sulfate infusion does not effectively prevent postoperative atrial fibrillation in cardiac surgery, especially when used alongside standard beta
Extracorporeal Cardiopulmonary Resuscitation for Pediatric Out-of-Hospital Cardiac Arrest
In selected children with out-of-hospital cardiac arrest, extracorporeal CPR was associated with higher one-month survival and better neurologic outcomes than continued conventional CPR, though the study was observational and estimates were
Pulmonary Artery Pressure Falls After ARNI and MRA Initiation, but Not SGLT2 Inhibitors, in Hemodynamically Monitored Heart Failure: Insights From GUIDE-HF
In a GUIDE-HF analysis using CardioMEMS, new ARNI and MRA initiation was associated with modest short-term reductions in diastolic pulmonary artery pressure, whereas SGLT2 inhibitor initiation showed no detectable pressure change and β-bloc
Premature Natural Menopause Signals Higher Lifetime Coronary Heart Disease Risk in Both Black and White Women
A pooled US cohort analysis found that natural menopause before age 40 was associated with about a 40% higher lifetime risk of coronary heart disease in both Black and White women, supporting its use as a routine cardiovascular risk-enhanci
Higher Hospital Myectomy Volume Was Linked to Fewer Early Complications in Dutch Hypertrophic Obstructive Cardiomyopathy Surgery
In a 12-hospital Dutch registry, surgical myectomy effectively relieved LVOT obstruction, but 30-day complications were more frequent in low-volume centers, in women, and when at least two concomitant procedures were performed.
Higher Interleukin-6 Levels Predict Broad Cardiovascular Risk and Mortality Across Diverse Cohorts
A pooled analysis of 59,396 participants found that higher serum IL-6 concentrations independently predicted nine cardiovascular and mortality outcomes, with consistent associations across key clinical subgroups.
Genome-First Data Suggest Familial Hypercholesterolemia Is Equally Prevalent Across African and European Ancestry Groups, but Underclassified in African Ancestry Patients
A large multi-cohort genome-first study found similar prevalence of pathogenic FH variants across ancestries, but more VUSs and greater LDL-C and myocardial infarction risk among African ancestry individuals, highlighting likely underclassi
Liberal Transfusion Still Appears Favored in Myocardial Infarction With Anemia, Regardless of Critical Illness Status
A MINT trial subanalysis found no evidence that ICU status changes the relative effect of restrictive versus liberal transfusion in acute myocardial infarction with anemia.
Younger Adults With Type 2 Diabetes Show a More Adverse Cardiometabolic Profile Than Older Adults
Across four national cohorts, younger adults with type 2 diabetes had higher adiposity and triglycerides, while glycemia peaked in midlife and blood pressure and albuminuria rose with age, suggesting age-specific pathways to diabetes compli
Routine Surgical Left Atrial Appendage Occlusion Did Not Improve 1-Year Outcomes in Valvular Surgery Patients Without Atrial Fibrillation: Insights From the OPINION Trial
In OPINION, prophylactic left atrial appendage occlusion during valve surgery did not significantly lower stroke, TIA, or cardiovascular death at 1 year in patients without pre-operative atrial fibrillation.
Implantable Monitor–Guided, Nurse-Led Diuretic Escalation Was Safe but Did Not Improve Outcomes in ALLEVIATE-HF
In ALLEVIATE-HF, ICM-based high-risk detection linked to centralized nurse-managed diuretic intervention was safe, but did not significantly improve the hierarchical composite outcome versus observation.
Circulating MicroRNA Scores May Distinguish Cellular and Antibody-Mediated Heart Transplant Rejection With High Accuracy
A prospective multicenter study found circulating microRNA rejection scores identified ACR and AMR with strong diagnostic performance and prognostic value, supporting their development as noninvasive tools to reduce reliance on surveillance
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