Ophthalmology
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Immune Checkpoint Inhibitor-Associated Uveitis: Comparative Risk Across Cancers and Drug Classes
A multicenter study found that immune checkpoint inhibitor–associated uveitis risk varies by cancer type and drug class, with melanoma showing the highest intrinsic risk and RCC risk largely linked to ipilimumab/nivolumab exposure.
A Clinically Relevant Threshold of Impaired Contrast Sensitivity Among Older US Adults
A large U.S. study found that a contrast sensitivity score of 1.60 logCS marks the point where older adults are more likely to experience everyday vision disability, even when standard visual acuity may seem acceptable.
No Signal for Increased Neovascular AMD Risk With Semaglutide in Adults With Type 2 Diabetes: Interpretation of a Large OHDSI Network Study
A multinational OHDSI network analysis found no meaningful association between semaglutide use and neovascular age-related macular degeneration among adults with type 2 diabetes across cohort and self-controlled designs.
Progression in Preperimetric Glaucoma Eyes With and Without Microvasculature Dropout
In preperimetric glaucoma, baseline microvasculature dropout on OCTA predicted faster capillary density loss and a higher risk of later visual field damage, suggesting it may help identify eyes needing closer follow-up.
Progression in Preperimetric Glaucoma Eyes With and Without Microvasculature Dropout
Eyes with preperimetric glaucoma and baseline microvasculature dropout progressed faster in capillary density loss and were more likely to develop visual field damage.
Pathologic Myopia Globe Shape and Long-Term Prognosis
Three-dimensional eye shape on MRI predicted 15-year outcomes in high myopia. Nasally distorted and conical eyes had the highest risk of rapid elongation, macular thinning, myopic degeneration, and visual field defects.
A Pain-Predominant Dry Eye Phenotype Emerges: Severe Symptoms, Few Ocular Signs, and Strong Links to Migraine and Psychiatric Disease
A 2026 Ophthalmology report identified a pain-predominant dry eye phenotype in 6.9% of patients, marked by high symptom burden, minimal surface signs, and enrichment for migraine and psychiatric comorbidity.
Optical Coherence Tomography Features of Inactive Multifocal Choroiditis with Panuveitis and Punctate Inner Choroidopathy Lesions
OCT imaging revealed that inactive MFCPU/PIC lesions commonly show Bruch’s membrane disruption, inner retinal herniation, and focal choroidal excavation, helping distinguish them from inflammatory and infectious mimickers.
Ocular Inflammation Linked to Higher Risk of Anti-Adalimumab Antibodies in Autoimmune Disease Patients
Ocular inflammation was linked to a higher risk of anti-adalimumab antibody formation in patients treated with adalimumab. More than 20% developed antibodies, supporting closer monitoring and therapeutic drug testing in high-risk patients.
Predictors of 1-Year Visual Outcome in Central-Involving Submacular Hemorrhage Secondary to Neovascular AMD
This study found that younger age, better baseline vision, smaller hemorrhage size, and thicker subfoveal choroid predicted better 1-year visual outcomes after fovea-involving submacular hemorrhage from nAMD or PCV.
Nonexudative Macular Neovascularization in Age-Related Macular Degeneration
In patients with unilateral exudative AMD, double-layer sign on OCT was common, but OCT angiography showed nonexudative macular neovascularization in only about 40% of DLS-positive fellow eyes.
Genomic Risk Profiling May Help Predict Which Patients With Fuchs Endothelial Corneal Dystrophy Progress to Keratoplasty
A 2026 Ophthalmology study suggests that combining CTG18.1 expansion testing with a FECD-specific polygenic risk score can improve prediction of keratoplasty risk across independent cohorts.
Anesthesia-Related Neurologic Risk in Patients of Venezuelan Descent: Implications for Ophthalmology
A rare, severe neurologic complication has been linked to general anesthesia in patients of maternal Venezuelan descent. Ophthalmologists should screen for ancestry and family history, involve anesthesiology early, and consider genetic eval
Small Copy Number-Neutral Intrachromosomal Translocation of PAX6 and Aniridia
Optical genome mapping and long-read sequencing uncovered a tiny balanced rearrangement that separated PAX6 from its control region, explaining classic aniridia after prior testing was negative.
Intraoperative Intravitreal Bevacizumab Extended Trabeculectomy Survival to 3 Years in a Randomized Trial
A double-blind randomized trial found that a single intraoperative intravitreal bevacizumab injection improved 3-year trabeculectomy survival and reduced postoperative medication needs versus placebo.
Delayed Glaucoma Follow-Up Was Usually Not Linked to Visual Field Progression, but Longer Gaps May Matter in More Advanced Disease
In a large retrospective glaucoma cohort, delayed follow-up was common yet was not generally associated with visual field worsening, although longer delays appeared more consequential in eyes with worse baseline visual field loss.
Optimizing Geographic Atrophy Clinical Trial Design: The Role of Run-In Phases, Single-Arm Architectures, and Functional Endpoints
This review synthesizes evidence on improving geographic atrophy trial efficiency through innovative run-in phases, single-arm designs, and superior functional biomarkers like microperimetry to reduce required sample sizes.
GLP-1 Weight-Loss and Diabetes Drugs: What Eye Specialists Say About NAION Risk
A new consensus statement advises cautious, shared decision-making about GLP-1 receptor agonists and NAION risk, noting that current evidence is observational, conflicting, and suggests any absolute risk increase is small.
Persistent Challenges in Managing Monocular Deprivation Amblyopia: A Three-Decade Trend Analysis of Infant Unilateral Cataract Outcomes
This review evaluates 30 years of clinical outcomes for monocular congenital cataracts, revealing stagnant visual acuity results, high surgical burdens, and significant rates of secondary glaucoma and nystagmus despite surgical advances.
Association of FOXC1 Duplications With Juvenile Open-Angle Glaucoma
A multicenter study found FOXC1 duplications in multiple glaucoma families, strongly linked to juvenile open-angle glaucoma with high penetrance and variable eye and subtle systemic features, supporting routine copy-number testing in select
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