Ophthalmology
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The Impact of Medication Storage Location on Glaucoma Eyedrop Adherence: A Home-Based Assessment Using Electronic Monitoring
Study reveals storing glaucoma eyedrops in kitchens or bathrooms improves adherence by 60-70% compared to bedrooms, with evening doses most frequently missed. Environmental factors like lighting showed minimal impact.
MBD4 Germline Variants Mark a Strong Predisposition to Uveal Melanoma, Supporting Broad Genetic Screening
A large French case series found pathogenic or likely pathogenic germline MBD4 variants in 23 of 896 patients with uveal melanoma, corresponding to a 31-fold relative risk versus the general population.
No Clear Winner in Severe Congenital Ptosis Repair: AAO Review Finds Overlapping Efficacy but Distinct Surgical Risks in Children
An American Academy of Ophthalmology review found that frontalis flap, frontalis suspension, and maximal levator resection show overlapping success and exposure rates in severe congenital ptosis, with surgical choice often guided more by co
Teprotumumab for Thyroid Eye Disease Carries a Measurable Long-Term Dysglycemia Risk
A large multinational cohort study found that teprotumumab use in thyroid eye disease was associated with higher risks of prediabetes, diabetes, and antidiabetes medication initiation over 5 years.
Glucagon-Like Peptide-1 Receptor Agonists and Vascular Protection: Mitigating Systemic and Ocular Risks in High-Risk Type 2 Diabetes
A large-scale cohort study demonstrates that GLP-1 RAs significantly reduce macrovascular and microvascular complications, including proliferative retinopathy and retinal vein occlusion, in patients with pre-existing diabetic retinopathy.
Brolucizumab Outperforms Laser Therapy in Proliferative Diabetic Retinopathy: Insights from the CONDOR Trial
The CONDOR trial demonstrates brolucizumab’s superiority over panretinal photocoagulation in preserving vision and reducing disease progression in proliferative diabetic retinopathy, offering a potential shift in treatment paradigms.
DSDO Lenses Show Superior Axial Length Control in Pediatric Myopia Management: A Real-World Multicenter Study
DSDO lenses demonstrated significant efficacy in slowing axial elongation in myopic and non-myopic children, with pronounced effects in younger age groups and low myopia subgroups during the first 6 months of intervention.
Whole Genome Sequencing Outperforms Gene Panels in Diagnosing Congenital Cataracts
Whole genome sequencing (WGS) increases diagnostic yield by 10% compared to gene panels in congenital cataracts, aiding in prognosis, reproductive counseling, and management.
Personalized Glaucoma Coaching Boosts Medication Adherence by 20%: SEE Program Trial Results
A 6-month personalized coaching program (SEE) significantly improved glaucoma medication adherence by 19.7% compared to standard education, reducing vision loss risk in a randomized trial of 235 patients.
High Glaucoma Risk in Pseudoexfoliation Syndrome: Age and Ocular Hypertension Drive Incidence
New study reveals 26.5-37.5% of eyes with pseudoexfoliation syndrome develop glaucoma within 4 years, with ocular hypertension doubling risk. Standalone lens extraction reduced IOP by 3 mmHg.
Association of Deep Optic Nerve Head Structural Remodeling with Choroidal Microvasculature Dropout in Glaucoma with and without Myopia
Study reveals significant links between optic nerve head structural changes and choroidal microvascular dropout in glaucomatous eyes, particularly in myopia. Deep structural parameters like neural canal geometry strongly correlate with micr
Open Globe Repair Carries the Highest Endophthalmitis Risk, and Pediatric Cataract Surgery Outpaces Adult Surgery in IRIS Registry Data
An IRIS Registry analysis of 17.5 million procedures found endophthalmitis was rare overall but highest after open globe repair, with pediatric cataract surgery carrying more risk than adult surgery.
Challenging the Assumption: Fellow-Eye Correlations in Geographic Atrophy Progression Prove Modest at Best
A post hoc analysis of AREDS2 reveals that geographic atrophy enlargement rates between fellow eyes show only modest correlations, challenging the common assumption that bilateral GA progresses similarly. The findings have important implica
Diabetic Retinopathy Severity Predicts Mortality Risk: Insights from the SOURCE Consortium
A retrospective cohort study of 524,687 diabetic patients reveals that increasing severity of diabetic retinopathy correlates with significantly higher mortality risk, with proliferative DR patients showing a 128% increased hazard of death
Deep Capillary Plexus Defects Emerge as a Universal Biomarker for Retinal Ischemia Across All Retinal Regions in Diabetic Retinopathy
Novel OCTA biomarkers reveal that geometric perfusion deficits in the deep capillary plexus serve as robust predictors of retinal nonperfusion across posterior, peripheral, and total retinal regions, while foveal avascular zone enlargement
Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy: Synthesizing Evidence from Target Trial Emulations and Global Pharmacovigilance
This review synthesizes recent evidence regarding the association between semaglutide initiation and nonarteritic anterior ischemic optic neuropathy (NAION), contrasting high-risk findings in real-world cohort studies with neutral findings
FAc Intravitreal Implant Achieves Comparable Visual Outcomes with 53% Fewer Injections in Diabetic Macular Edema: Phase 4 NEW DAY Study
The Phase 4 NEW DAY study demonstrates that fluocinolone acetonide (FAc) 0.19 mg implant as baseline therapy achieves similar visual acuity and anatomical improvements compared to aflibercept in diabetic macular edema patients, while signif
Why the New MS Diagnostic Criteria Require Caution: High Frequency of MOGAD and NMOSD in Optic Neuritis Patients
A retrospective study reveals that 24% of patients meeting the latest MS criteria following optic neuritis actually have MOGAD or NMOSD, emphasizing the need for antibody testing to prevent misdiagnosis.
Microvascular Dropout and Parapapillary Atrophy Progression Predict Structural Optic Disc Damage in Glaucoma Suspects
A 19-year retrospective study reveals that microvascular dropout and β-zone parapapillary atrophy progression are powerful independent predictors of structural optic disc damage in glaucoma suspects, even when visual fields remain stable.
Seeing the Invisible: New Global Consensus on Using Advanced Imaging to Track Uveitis Activity
A global task force has established new standardized imaging measures to define disease activity in non-infectious posterior uveitis, bridging a critical gap in clinical diagnosis and trial monitoring.
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