Section
A systematic quality improvement program integrating EHR tools and universal opt-out protocols significantly increased chlamydia and gonorrhea screening and case detection among adolescents in a large pediatric primary care network.
This study evaluates how low levels of pyuria influence antibiotic prescribing in children with suspected urinary tract infections (UTIs), revealing that minor pyuria often leads to unnecessary antibiotic use.
A comprehensive 15-year population-based study in Catalonia reveals that over 40% of sepsis survivors die within two years post-discharge, highlighting significant impacts of age, comorbidities, and hospital stay duration on long-term outco
This study reveals that the viral RNA sensor RIG-I in platelets modulates thrombotic responses during influenza infection, limiting thrombosis and facilitating immune cell transmigration through a unique signaling pathway.
The AASLD EXPO gives timely, consensus-driven guidance: screen all HBsAg-positive persons once for anti-HDV, confirm viremia with HDV RNA, stage with elastography, and treat compensated chronic HDV with bulevirtide (± peg‑IFN) while monitor
Shotgun metagenomic sequencing reveals significant taxonomic and functional shifts in the salivary microbiome, correlating with stages of periodontal disease, highlighting potential biomarkers for early detection and risk stratification.
Using organs from Trypanosoma cruzi-positive donors expands transplant availability in endemic regions but necessitates vigilant monitoring to manage Chagas disease reactivation safely.
Implementation of the HALT-C antenatal linkage-to-care bundle significantly increased hepatitis C treatment initiation and completion by six months postpartum, with majority of patients preferring antenatal therapy, demonstrating pregnancy
This study reveals that periodontitis in allo-HSCT patients shifts bloodstream infection profiles towards non-viridans streptococci and associates with higher mortality, highlighting the importance of oral health in transplant outcomes.
A multicenter Chinese study developed and externally validated the Psoriasis TB Risk Score (PTRS) to stratify psoriasis patients’ risk of high interferon-γ release assay (IGRA) responses before biologic treatment, facilitating tailore
Abdominal solid organ transplant recipients with sepsis show improved survival linked to distinctive immune and metabolic signatures, including attenuated inflammation and preserved innate immunity, providing novel insights for clinical man
B-BEST, a novel single-cell RNA sequencing technique, reveals heterogeneity in HBV-infected hepatocytes, linking viral replication states to host cellular pathways, inflammation, and antiviral responses, with implications for precision HBV
This study elucidates how Porphyromonas gingivalis-induced neutrophil extracellular traps (NETs) contribute to neuroinflammation and cognitive impairment through TLR4 activation, revealing a mechanistic link between periodontitis and Alzhei
Delayed appropriate antifungal therapy after the onset of persistent hypotension dramatically increases mortality in Candida septic shock; survival drastically improves with treatment within 2 hours.
This review synthesizes evidence on the characteristic clinical and histopathologic features of condyloma lata in secondary syphilis, emphasizing its reliable recognition to prevent misdiagnosis, especially at extragenital sites.
PHH-1V, a protein-based COVID-19 vaccine, is shown to be a safe and effective heterologous booster in adolescents, generating strong and lasting immune responses against multiple virus variants.
A phase 3 trial demonstrates that once-weekly oral islatravir-lenacapavir is as effective and safe as daily bictegravir-emtricitabine-tenofovir alafenamide in maintaining HIV-1 viral suppression, offering a promising option to improve adher
This prospective Scottish study compares cytology and high-risk HPV testing performance in young HPV-vaccinated women, revealing high negative predictive value but lower positive predictive value of hrHPV testing, emphasizing the role of cy
A 2026 expert consensus recommends shorter, individualized antibiotic courses for most severe infections in critically ill patients, with clear exceptions and guidance on biomarkers, source control, and stewardship.
A fast-moving and geographically unprecedented Ebola outbreak that began in the Democratic Republic of the Congo has extended into four additional cou
