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SPP1-Positive Macrophages Shape Immunosuppression in Colorectal Cancer Lymph Nodes

Single-cell profiling of colorectal cancer lymph nodes revealed an SPP1–CD44–NF-κB1 pathway that promotes CD137+ regulatory T-cell maturation and may be therapeutically targetable.

GastroenterologyJun 20, 2026

Validated Early Detection Metrics Could Narrow Liver Fibrosis Screening Without Losing Clinical Signal

A validation study suggests current liver fibrosis screening criteria are too broad. A refined risk-based approach reduced eligibility from 60–76% to 10–22% of adults while improving the yield of elevated liver stiffness and predicting futu

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SPP1-Positive Macrophages Shape Immunosuppression in Colorectal Cancer Lymph Nodes

Validated Early Detection Metrics Could Narrow Liver Fibrosis Screening Without Losing Clinical Signal

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New Consensus Maps the Future of Pediatric Stroke Rehabilitation in Australia and New Zealand

A New Way to Measure Prodromal Synucleinopathy: What the PSRS Adds for RBD Clinical Trials

Brain Imaging Biomarkers and Cognitive Outcomes in a Multidomain Lifestyle Intervention: The POINTER Imaging Ancillary Study

Thyroid Hormones May Offer a New Therapeutic and Prognostic Angle in ADPKD

Time-Restricted Eating vs Dietetic Guidance for Glycaemic Outcomes in Adults at Risk of Type 2 Diabetes