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Targeting IGF2BP2: A Novel Therapeutic Avenue in Peripheral T-cell Lymphoma Through RNA Modification and Immune Modulation
Hematology-OncologyTumor Microenvironmentm6A RNA modification

Targeting IGF2BP2: A Novel Therapeutic Avenue in Peripheral T-cell Lymphoma Through RNA Modification and Immune Modulation

By MedXY|Sep 24, 2026

This article explores the pivotal role of IGF2BP2, an N6-methyladenosine reader, in driving tumor growth and immune evasion in peripheral T-cell lymphoma, highlighting its potential as a dual-action therapeutic target.

Dynamic Genetic and Nongenetic RAS-Pathway Activation Drives Resistance to FLT3 and BCL2 Inhibitor Therapy in AML
Clinical Updatesdrug resistance

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news6829 articlesCardiology1403 articlesClinical Updates1315 articlesOncology1176 articlesDiabetes & Endocrinology868 articlesNeurology834 articlesPublic Health605 articlesGastroenterology586 articles
BCL2 inhibitor

Dynamic Genetic and Nongenetic RAS-Pathway Activation Drives Resistance to FLT3 and BCL2 Inhibitor Therapy in AML

By MedXY|Sep 24, 2026

This review synthesizes cutting-edge findings on how genetic and nongenetic RAS-pathway activation mediates resistance to combined FLT3 and BCL2 inhibition in acute myeloid leukemia, highlighting implications for treatment strategies and bi

Cost-Effectiveness of Thoracentesis with Pleural Fluid Cytology Versus Thoracoscopy with Pleural Biopsy in Diagnosing Malignant Pleural Effusion
newsCost-Effectivenessmalignant pleural effusion

Cost-Effectiveness of Thoracentesis with Pleural Fluid Cytology Versus Thoracoscopy with Pleural Biopsy in Diagnosing Malignant Pleural Effusion

By MedXY|Sep 24, 2026

This study evaluates when thoracentesis or thoracoscopy is more cost-effective in diagnosing malignant pleural effusion in patients with prior or active malignancy, highlighting thresholds of pleural fluid cytology sensitivity guiding optim

Quantitative CT-Based Mixed Mucus Plug-Emphysema Phenotyping Predicts Exacerbation Risk in COPD: Integrating Imaging Biomarkers for Precision Medicine
Clinical UpdatesCOPDacute exacerbation

Quantitative CT-Based Mixed Mucus Plug-Emphysema Phenotyping Predicts Exacerbation Risk in COPD: Integrating Imaging Biomarkers for Precision Medicine

By MedXY|Sep 24, 2026

This review synthesizes recent evidence on quantitative CT markers of mucus plugging and emphysema in COPD, highlighting their combined impact on acute exacerbation risk and clinical heterogeneity, and discusses implications for personalize

Rising Burden of Non-Cystic Fibrosis Bronchiectasis in U.S. Primary Care: A Decade of Prevalence Trends and Demographic Insights (2015–2025)
Internal Medicineprevalencebronchiectasis

Rising Burden of Non-Cystic Fibrosis Bronchiectasis in U.S. Primary Care: A Decade of Prevalence Trends and Demographic Insights (2015–2025)

By MedXY|Sep 24, 2026

A large-scale EHR study reveals a 133% increase in non-cystic fibrosis bronchiectasis prevalence in U.S. adults from 2015 to 2025, with marked demographic disparities.

Optimizing Pediatric Cardiac Arrest Outcomes through Airway Patency Assessment via Capnography
Critical Care儿科心搏骤停Airway opening index

Optimizing Pediatric Cardiac Arrest Outcomes through Airway Patency Assessment via Capnography

By MedXY|Sep 24, 2026

This study demonstrates that higher airway opening index (AOI), measured by capnography during pediatric CPR, correlates with improved survival and neurological outcomes. AOI is a novel, quantitative marker of airway patency linked to post-

Retinal Vasculometry Predicts Visual Field Progression in Primary Open Angle Glaucoma: Insights from Automated Fundus Photography Analysis
newsvisual field progressionprimary open-angle glaucoma

Retinal Vasculometry Predicts Visual Field Progression in Primary Open Angle Glaucoma: Insights from Automated Fundus Photography Analysis

By MedXY|Sep 24, 2026

Baseline retinal vascular features quantified by automated deep learning on fundus photographs are associated with future visual field decline in primary open-angle glaucoma, offering potential prognostic biomarkers to enhance patient risk

Predictors of Vision Loss in Chronic Stevens-Johnson Syndrome: Insights from a Nationwide Multicenter Cohort Study
newsStevens-Johnson syndromelimbal stem cell deficiency

Predictors of Vision Loss in Chronic Stevens-Johnson Syndrome: Insights from a Nationwide Multicenter Cohort Study

By MedXY|Sep 24, 2026

This study identifies key clinical features and risk factors predicting surgery and vision loss in chronic Stevens-Johnson syndrome, emphasizing the need for early referral and standardized care protocols.

Advancing Laryngeal Examination: Real-Time Functional Behavior Classification via Vocal Fold Kinematics
AIlaryngeal behaviorsvocal fold kinematics

Advancing Laryngeal Examination: Real-Time Functional Behavior Classification via Vocal Fold Kinematics

By MedXY|Sep 24, 2026

A novel real-time model accurately classifies functional laryngeal behaviors from videolaryngoscopy data, enhancing clinical assessment and automation potential for voice disorder diagnostics.

Frailty as a Predictor of Surgical Outcomes in Cricopharyngeus Muscle Dysfunction: Enhancing Patient Selection and Expectations
General Surgeryupper esophageal sphincterFrailty

Frailty as a Predictor of Surgical Outcomes in Cricopharyngeus Muscle Dysfunction: Enhancing Patient Selection and Expectations

By MedXY|Sep 23, 2026

Frailty negatively impacts swallowing improvement after UES surgery for cricopharyngeus muscle dysfunction, with nonfrail patients experiencing greater benefits. Frailty assessment aids preoperative planning without excluding patients from

Histopathologic Insights in Chronic Rhinosinusitis Linked to Intranasal Substance Use: Implications for Clinical Management
newsHistopathologyneutrophilic inflammation

Histopathologic Insights in Chronic Rhinosinusitis Linked to Intranasal Substance Use: Implications for Clinical Management

By MedXY|Sep 23, 2026

This study reveals distinct histopathologic features in chronic rhinosinusitis patients with intranasal substance use, highlighting increased neutrophilic inflammation and epithelial remodeling, underscoring the need for targeted clinical a

Environmental Burden and Its Influence on Surgical Outcomes: Unveiling the Hidden Disparities
General Surgeryhealth disparitiessurgical outcomes

Environmental Burden and Its Influence on Surgical Outcomes: Unveiling the Hidden Disparities

By MedXY|Sep 23, 2026

This study links environmental burdens, notably air pollution and proximity to transportation, to increased postoperative complications, revealing a critical pathway for health disparities in surgery.

Advancing Surgical Quality Assessment in Distal Gastrectomy: Automated Evaluation of the Critical View of Quality Using Computer Vision
AIChất lượng phẫu thuậtComputer Vision

Advancing Surgical Quality Assessment in Distal Gastrectomy: Automated Evaluation of the Critical View of Quality Using Computer Vision

By MedXY|Sep 23, 2026

This study validates the Critical View of Quality (CVQ) as an intraoperative metric of lymphadenectomy quality in distal gastrectomy and presents a novel computer vision model for its automated video-based assessment, enhancing objective su

Neurotensin Receptor 1: A Key Driver of Immune Exclusion and Poor Prognosis in Colorectal Cancer
GastroenterologyTumor MicroenvironmentNeurotensin Receptor 1

Neurotensin Receptor 1: A Key Driver of Immune Exclusion and Poor Prognosis in Colorectal Cancer

By MedXY|Sep 23, 2026

High expression of neurotensin receptor 1 (NTSR1) defines an immune-cold colorectal cancer subtype linked to worse outcomes by creating mechanical and biological barriers that exclude T-cell infiltration, highlighting a novel immunotherapeu

Laparoscopic Modified Davydov’s Technique for Vaginoplasty: Operative Steps and Technical Pearls
newscase reportdiagnosis

Laparoscopic Modified Davydov’s Technique for Vaginoplasty: Operative Steps and Technical Pearls

By MedXY|Sep 21, 2026

A 21-year-old woman with Müllerian agenesis underwent a standardized laparoscopic modified Davydov vaginoplasty, achieving an 11 cm neovagina with intact function and no complications at 6-month follow-up.

Escalating Antihypertensive Therapy in Early-Onset Severe Preeclampsia: Dynamic Marker of Maternal Risk During Expectant Management
Internal Medicineexpectant managementpreeclampsia

Escalating Antihypertensive Therapy in Early-Onset Severe Preeclampsia: Dynamic Marker of Maternal Risk During Expectant Management

By MedXY|Sep 23, 2026

Escalation of antihypertensive treatment in expectant management of early-onset preeclampsia with severe features correlates with increased maternal adverse outcomes, suggesting treatment trajectory as a dynamic risk indicator.

Rising Trends and Clinical Outcomes of Outpatient Hysterectomy in Ontario: A Population-Based Analysis
newshealth outcomesPhẫu thuật xâm lấn tối thiểu

Rising Trends and Clinical Outcomes of Outpatient Hysterectomy in Ontario: A Population-Based Analysis

By MedXY|Sep 23, 2026

Outpatient hysterectomy has increased significantly in Ontario from 2010 to 2024, showing favorable 90-day readmission rates, reduced complications, and lower health system costs compared to inpatient procedures.

Divergent Microbial Mechanisms and Predictive Signatures in Necrotising Enterocolitis: The Role of Gut Phages and Bacterial Resistomes
Clinical Updatesgut microbiomebacterial resistome

Divergent Microbial Mechanisms and Predictive Signatures in Necrotising Enterocolitis: The Role of Gut Phages and Bacterial Resistomes

By MedXY|Sep 23, 2026

This review synthesizes evidence on the predictive and pathogenic roles of gut phages and bacterial resistomes in necrotising enterocolitis, highlighting divergent mechanisms for early- versus late-onset disease and translational opportunit

Reevaluating Immune Tolerant Phase in Chronic Hepatitis B: High Transition Rates to Immune Active Disease and Clinical Implications from the RADICAL Consortium
Gastroenterologychronic hepatitis BFibrosis progression

Reevaluating Immune Tolerant Phase in Chronic Hepatitis B: High Transition Rates to Immune Active Disease and Clinical Implications from the RADICAL Consortium

By MedXY|Sep 23, 2026

The RADICAL consortium’s large-scale study reveals a high long-term transition rate from immune tolerant to immune active chronic hepatitis B, especially in patients with high-normal ALT, suggesting the need for closer monitoring and

Optimizing Etiologic Investigations After Status Epilepticus: Diagnostic Yield and Therapeutic Implications from the ICTAL Registry
Critical Carediagnostic yieldstatus epilepticus

Optimizing Etiologic Investigations After Status Epilepticus: Diagnostic Yield and Therapeutic Implications from the ICTAL Registry

By MedXY|Sep 23, 2026

Etiologic investigations after status epilepticus (SE) demonstrate variable diagnostic yield and significantly influence treatment decisions, especially when guided by clinical pretest probability. Tailored diagnostic strategies enhance tim

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