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The clinical briefing

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8,371 articles

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Pediatrics

A U.S. Islamic Fatwa Supporting Pasteurized Donor Human Milk: How Clinicians Can Use Faith Guidance to Improve Neonatal Equity

A 2023 fatwa by the Minnesota Islamic Council endorses pasteurized donor human milk when a mother’s milk is unavailable. This article summarizes the religious clarification, aligns it with clinical guidance, and offers practical steps

Nov 11, 2026
Rheumatology

Rising Global Impact and Economic Burden of Musculoskeletal Disorders Among Working-Age Adults (1990–2023)

Musculoskeletal disorders are the leading cause of disability and productivity loss globally in working-age populations, with a projected 24% rise in burden by 2050, predominantly affecting high-income countries and driven by obesity and er

Nov 11, 2026
Nephrology

Transplanting Organs from Trypanosoma cruzi-Positive Donors: Balancing Risks and Benefits for Liver and Kidney Recipients

Using organs from Trypanosoma cruzi-positive donors expands transplant availability in endemic regions but necessitates vigilant monitoring to manage Chagas disease reactivation safely.

Nov 11, 2026
Dermatology

Low-Dose Intralesional Cemiplimab Shows Promising Efficacy in Early-Stage Cutaneous Squamous Cell Carcinoma: Insights from a Phase 1 Dose-Escalation Study

A phase 1 study demonstrates that low-dose intralesional cemiplimab is safe and achieves high complete response rates in early-stage cutaneous squamous cell carcinoma, supporting further clinical exploration.

Nov 11, 2026
Plastic Surgery

Timing of Autologous Breast Reconstruction Post-Radiotherapy: Evaluating Safety and Outcomes

This article reviews a study on the impact of timing between postmastectomy radiotherapy and autologous breast reconstruction, highlighting no significant differences in complication rates across various intervals.

Nov 11, 2026
Psychiatry

Mobile Units for Integrated Addiction and HIV Prevention Services for People Who Inject Drugs: Insights from the HPTN 094 Randomized Clinical Trial

This review synthesizes evidence from the HPTN 094 trial assessing mobile integrated PrEP and MOUD services versus peer navigation for people who inject drugs, highlighting key outcomes, limitations, and implications for HIV prevention and

Nov 11, 2026
Critical Care

Tailoring High Flow Nasal Oxygen Therapy in Immunocompromised Patients with Acute Respiratory Failure: Insights from Machine Learning

A study using causal forest algorithms reveals heterogeneous benefits of high flow nasal oxygen in immunocompromised patients with acute respiratory failure, identifying subgroups who may significantly avoid invasive mechanical ventilation.

Nov 11, 2026
Nephrology

Enhancing Patient-Centered Care in End-Stage Kidney Disease: Development and Evaluation of the ESKD Life Plan Toolkit

This article reviews the development and preliminary evaluation of a novel toolkit designed to facilitate patient-centered decision-making in end-stage kidney disease, improving the implementation of the KDOQI End-Stage Kidney Disease Life

Nov 11, 2026
Hematology-Oncology

USP22 as a Therapeutic Vulnerability in KMT2A-Rearranged Acute Leukemia: Regulating MEIS1 Stability and Oncogenic Transcription

Recent evidence identifies USP22 as a key regulator of MEIS1 protein stability, revealing a promising therapeutic target to disrupt leukemogenic transcription in KMT2Ar acute leukemia.

Nov 11, 2026
Cardiology

Addressing Under-Detection of Sleep Apnea in Black Individuals: The Role of Racial Differences in Oxygen Desaturation and Heart-Rate Response

This article examines how pulse oximetry may under-detect sleep apnea events in Black individuals due to skin pigmentation-related measurement bias, highlighting heart-rate response as a reliable, pigmentation-independent marker predictive

Nov 11, 2026
Ophthalmology

Intravenous Bisphosphonates Linked to Increased Short-Term Uveitis Risk: Insights from a Nationwide Taiwan Study

A large nationwide case-case-time-control study revealed intravenous bisphosphonates, especially zoledronic acid, are associated with a short-term increased risk of uveitis, with no clear links to scleritis or cystoid macular edema.

Nov 11, 2026
Otorhinolaryngology

Limitations of Preoperative Ultrasound in Predicting Papillary Thyroid Carcinoma Features: Clinical Implications for Surgical Planning

This study reveals that preoperative ultrasound frequently overestimates papillary thyroid carcinoma tumor size and has limited accuracy for detecting multifocality and extrathyroidal extension, suggesting caution in surgical decision-makin

Nov 11, 2026
Gastroenterology

VEGFA and EGF Genetic Variants: Impact on Cholangiocarcinoma Susceptibility and Postoperative Prognosis

VEGFA and EGF polymorphisms differentially affect cholangiocarcinoma susceptibility and postoperative survival, highlighting their potential as biomarkers for clinical stratification.

Nov 11, 2026
OB/GYN & Women's Health

Insights from a Randomized Trial: Comparing Standard and Lower Pressure Pneumoperitoneum in Laparoscopic Gynecologic Surgery

A randomized controlled trial shows that lower insufflation pressures during laparoscopic gynecologic surgery do not reduce postoperative pain but maintain adequate visualization, supporting individualized pressure use.

Nov 11, 2026
Gastroenterology

Statins, Aging, and Liver Health: Unraveling Age and Sex Influence on Transcriptomic Responses in MASLD

This study reveals how age and sex modulate liver transcriptomic responses to statin therapy in metabolic dysfunction-associated steatotic liver disease (MASLD), highlighting statins’ potential to suppress liver aging by targeting sen

Nov 11, 2026
Neurology

Reproductive Lifespan and Hormonal Therapy in Relation to Later-Life Neurovascular Health in Community-Dwelling Older Women: An Evidence-Based Review

This review synthesizes evidence linking lifetime estrogen exposure—both endogenous and exogenous—with neurovascular integrity and Alzheimer’s disease risk in older women, highlighting the impact of reproductive lifespan and hormone t

Nov 11, 2026
Diabetes & Endocrinology

Increasing Trends in Diabetes During Pregnancy and Associated Severe Maternal Morbidity in U.S. Deliveries (2016-2022)

From 2016 to 2022, gestational and pregestational diabetes prevalence rose alongside severe maternal morbidity in U.S. deliveries, with type 1 diabetes presenting the highest risk for severe complications.

Nov 11, 2026
Cardiology

Simplifying Access Site Closure in Transfemoral TAVR: Insights from the SINGLE-CLOSURE Trial

The SINGLE-CLOSURE trial demonstrated that single-ProGlide closure is noninferior to double-ProGlide closure in reducing vascular complications after transfemoral TAVR, offering a simpler alternative without increased risk.

Nov 11, 2026
Orthopedics

Postoperative Pudendal Nerve Palsy After Hip Arthroscopy: Incidence, Traction Influence, and Clinical Outcomes

Pudendal nerve palsy occurs frequently after hip arthroscopy using a perineal post, with symptoms commonly resolving by one year. Increased traction duration and force are significant risk factors, and persistent symptoms impair hip-specifi

Nov 11, 2026
Diabetes & Endocrinology

Enhancing Functional Capacity in Obesity: The Role of Functional Inspiratory Muscle Training

A randomized controlled trial demonstrates that functional inspiratory muscle training integrated with resistance exercise improves functional capacity and respiratory muscle performance in individuals with obesity, complementing benefits f

Nov 11, 2026
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    Precision Medicine for Long QT Syndrome Type 2: Lumacaftor Corrects Trafficking Defects and Shortens QT Interval

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    Optimizing Postoperative Opioid Prescriptions After Intra-Abdominal Cancer Surgery: Comparing the 5x-Multiplier and 3-Tier Models

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