The clinical briefing
November 13, 2026 — Confirmed measles cases in the United States have climbed to 5,412 as of November 12, marking an increase of 230 cases over the pa
A systematic quality improvement program integrating EHR tools and universal opt-out protocols significantly increased chlamydia and gonorrhea screening and case detection among adolescents in a large pediatric primary care network.
This 7-year longitudinal study using HR-pQCT reveals that seropositive rheumatoid arthritis patients experience greater trabecular bone deterioration versus psoriatic arthritis, with sustained remission preserving bone integrity across infl
Significant variability exists among US lung transplant centers in updating clinical data for candidates, potentially impacting allocation priority and transplant equity. Most variation remains unexplained by candidate or center characteris
This study assesses a novel biologic optimization strategy guided by the end-of-dose effect in partial responders with hidradenitis suppurativa, revealing meaningful clinical improvements and offering a framework for personalized treatment
Preoperative percutaneous endovascular intervention (PEI) before free tissue transfer (FTT) provides comparable durable limb salvage in patients with peripheral arterial disease and chronic lower-extremity wounds, despite higher postoperati
The FS-ICUshort, a validated 12-item questionnaire, maintains robust psychometric properties of the original FS-ICU while enhancing feasibility and completion rates, facilitating routine family satisfaction assessment and quality benchmarki
Wearable devices offer continuous, real-world data to enhance frailty assessments beyond conventional episodic clinical measures. Combining this data with the Hospital Frailty Risk Score (HFRS) facilitates earlier detection and intervention
This study demonstrates the promising safety and efficacy of CD20-targeted autologous CAR T-cell therapy in BTKi-refractory Waldenström macroglobulinemia, showing an 80% deep response rate and warranting further investigation in larger tria
This study investigates how decisions made by patients versus surrogates affect the intensity of end-of-life care and hospitalization costs in ICU settings, revealing that surrogate decisions often lead to higher care intensity and costs, p
This review analyzes a pragmatic RCT assessing EHR-embedded behavioral nudges to reduce low-value preoperative testing before cataract surgery, highlighting limited impact on overall testing but promising effects on specific test cancellati
This study identifies distinct microbial dysbiosis in laryngeal cancer, highlighting Parvimonas and Campylobacter as potential therapeutic targets based on microbiome profiling of treatment-naive patients compared to controls.
Liver transplantation offers superior long-term survival compared to resection for combined hepatocellular-cholangiocarcinoma, with outcomes comparable to hepatocellular carcinoma when selecting patients without vascular invasion or poor di
Cluster analysis of physiological parameters in women with urgency urinary incontinence reveals three distinct phenotypes, offering insights for personalized treatment strategies.
Elafibranor demonstrates significant efficacy and safety in normalizing alkaline phosphatase among PBC patients inadequately responding to UDCA, establishing ALP normalization as a treatment goal and supporting its role as a second-line the
The 2024 McDonald criteria revisions enable earlier MS diagnosis in many patients with radiologically isolated syndrome (RIS), potentially altering management before clinical symptoms arise, according to a large multicenter Italian study.
Persistent severe vitamin D deficiency during adolescence in girls with idiopathic scoliosis is linked to poorer bone mineral density and compromised bone structure into early adulthood, highlighting the need for targeted interventions.
The BioTAK score, a novel biomarker-driven diagnostic tool, accurately discriminates Takotsubo syndrome from acute coronary syndrome pre-angiography, streamlining diagnostic pathways and potentially reducing invasive procedures.
