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Short-Term Testosterone Replacement Improved Sexual and Physical Function After Radical Prostatectomy Without Biochemical Recurrence in Carefully Selected Prostate Cancer Survivors
A phase 2 randomized trial found that 12 weeks of testosterone cypionate improved sexual activity, desire, mood, body composition, and exercise performance in hypogonadal men after radical prostatectomy, with no biochemical recurrence obser
Poverty Exposure in Standard-Risk Pediatric B-ALL Is Linked to Steroid-Resistance Programs and an Immunologically Suppressed Leukemia Microenvironment
Single-cell RNA sequencing suggests that childhood poverty exposure is associated with steroid-resistance signatures in leukemic blasts and adverse immune remodeling at diagnosis in standard-risk B-ALL.
Early ctDNA MRD After Two Cycles Identifies Distinct Relapse Risk Groups in Advanced Hodgkin Lymphoma
In the GHSG HD21 trial, a validated ctDNA assay showed that MRD positivity after two treatment cycles strongly predicted inferior progression-free survival and improved early risk stratification, especially when combined with interim PET.
Transformative Survival Gains in Cystic Fibrosis: A Population-Level Evaluation of CFTR Modulator Therapy Effectiveness
A large-scale retrospective study using US CFF Registry data reveals that CFTR modulator therapy reduces the hazard of death by 66% over an eight-year period, marking a significant milestone in cystic fibrosis clinical outcomes and life exp
More Enteral Protein Did Not Overcome Anabolic Resistance in Mechanically Ventilated Critical Illness
In a randomized trial, a 40 g intraduodenal whey bolus increased amino acid availability but did not significantly raise postprandial muscle protein synthesis versus 20 g in critically ill ventilated adults.
Persistent Challenges in Managing Monocular Deprivation Amblyopia: A Three-Decade Trend Analysis of Infant Unilateral Cataract Outcomes
This review evaluates 30 years of clinical outcomes for monocular congenital cataracts, revealing stagnant visual acuity results, high surgical burdens, and significant rates of secondary glaucoma and nystagmus despite surgical advances.
Association of FOXC1 Duplications With Juvenile Open-Angle Glaucoma
A multicenter study found FOXC1 duplications in multiple glaucoma families, strongly linked to juvenile open-angle glaucoma with high penetrance and variable eye and subtle systemic features, supporting routine copy-number testing in select
Pigmentary Glaucoma Shows Higher Procedure Use and Worse Early Failure After LTP and MIGS Than Primary Open-Angle Glaucoma
A large IRIS Registry study found that pigmentary glaucoma undergoes more glaucoma procedures than POAG and has higher early failure after LTP and MIGS, with notable racial differences in disease severity.
Systematic V2 Vagal Stimulation Improves Detection of Post-Thyroidectomy Vocal Cord Dysfunction and May Better Guide Staged Surgery
A 2026 cross-sectional study suggests that routine postdissection vagal stimulation during thyroidectomy detects recurrent laryngeal nerve dysfunction more sensitively than RLN stimulation alone and may reduce the risk of bilateral vocal co
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