Respiratory
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Unveiling the Phenotype of Unclassified Pulmonary Hypertension: A Hidden Spectrum of Early Heart Failure with Preserved Ejection Fraction
Unclassified pulmonary hypertension often reflects early-stage HFpEF linked to left heart and metabolic dysfunction, identifiable via dynamic right heart catheterization and metabolomics.
Why One Sleep Study May Not Tell the Whole Story: Night-to-Night Variability, AHI Definitions, and OSA Reclassification
A recent Chest study shows that PSG metrics vary unevenly across nights, and AHI scored with 4% desaturation is less stable than AHI 3%/arousal. Hypoxic burden was more reproducible and may better reflect true OSA severity.
Early Neutrophil and Persistent Eosinophil Gene Signatures in Childhood Asthma
A longitudinal blood gene-expression study in children found an early neutrophil-driven immune pattern at age 1, followed by a persistent eosinophilic signature from 4.5 to 10.5 years in those who later developed asthma.
Laterality of Swimming-Induced Pulmonary Edema During Combat Sidestroke: Comparative Insights from Lung Ultrasound and Chest Radiography
This review synthesizes evidence on SIPE lateralization corresponding to dependent body position during combat sidestroke, highlighting moderate concordance between lung ultrasound and chest x-ray findings and implications for field diagnos
Mepolizumab and Blood Eosinophil Variability in COPD: A New Dimension in Targeted Therapy
This article reviews mepolizumab efficacy in COPD patients with variable blood eosinophil counts, showing benefits even with intermittent eosinophilia, expanding treatable phenotypes beyond persistent elevation.
Blood Cancer Proteins Plus Histoplasma Antibodies Improve Malignancy Assessment in Indeterminate Pulmonary Nodules
In two US cohorts, combining serum cancer biomarkers and Histoplasma antibodies with the Mayo model improved discrimination of benign versus malignant pulmonary nodules, especially in intermediate-risk cases.
Remote Respiratory Therapy Safely Replaced Most Bedside Ventilator Care in a Donor Center ICU
A prospective study found that fully remote respiratory therapy in a donor care ICU was feasible, safe, and labor-saving, with minimal need for bedside support and favorable organ recovery outcomes.
Bronchoscopy in Germany Generates More Than 550 Tons of Waste Annually, With Reusable PPE Offering the Largest Immediate Reduction
A multicenter German study shows pulmonary endoscopy produces substantial waste, much of it in procedure rooms, and suggests reusable gowns, procedural bundling, and recycling as practical ways to lower environmental impact.
Quantitative CT Progression Thresholds in Idiopathic Pulmonary Fibrosis May Sharpen Annual Monitoring and Risk Stratification
A multicenter study suggests that 1-year quantitative CT fibrosis progression in IPF, particularly a rise of about 4%, is clinically meaningful and prognostically informative for transplant-free survival.
Personalized Automatic Management of Tracheal Cuff Pressure and Subglottic Secretion Drainage to Prevent Pneumonia in Critically Ill Intubated Patients: The MICROINHALO Multicenter Randomized Controlled Trial
MICROINHALO found that automatic cuff pressure control plus subglottic secretion drainage did not reduce tracheal colonization, but it was linked to fewer ventilator-associated pneumonia cases in critically ill intubated patients.
A Chest X-Ray AI Age Gap May Flag Early Spirometric Decline Before Overt Lung Disease
In a large Korean health-screening cohort, chest radiograph-derived age acceleration was associated with both prevalent and incident PRISm and obstructive lung disease, supporting chest X-ray AI as a potential opportunistic marker of early
Negative End-Expiratory Transpulmonary Pressure, Lung Collapse, and Non-Focal ARDS Drive Tidal Recruitment During Pressure Support Ventilation
In spontaneously breathing ARDS patients on pressure support ventilation, tidal recruitment/derecruitment was strongly linked to more negative end-expiratory transpulmonary pressure, greater collapse, and non-focal infiltrates, while EIT-gu
Dietary Patterns and Asthma Endotypes in Puerto Rican Youth
In Puerto Rican youth, an unhealthy diet was linked to higher odds of T17-high asthma, suggesting diet may influence asthma through immune pathways beyond allergy-related inflammation.
CT Small-Artery Loss Tracks Severe Pulmonary Hypertension in COPD and Fibrosing ILD More Closely Than Parenchymal Damage
CT-derived pulmonary vascular metrics, especially the small-artery to total arterial volume ratio, identify severe pulmonary hypertension in chronic lung disease, with distinct vascular remodeling patterns in COPD and fibrosing ILD.
International Validation of Electronic Nose Technology as a Diagnostic Tool for Fibrotic Interstitial Lung Diseases
An international study found that electronic nose breath analysis can distinguish fibrotic interstitial lung disease subtypes with good accuracy, suggesting a promising noninvasive tool to support diagnosis.
International Validation of Electronic Nose Technology as a Diagnostic Tool for Fibrotic Interstitial Lung Diseases
An international multicenter study found that electronic nose breath analysis can help distinguish fibrotic interstitial lung disease subtypes with promising accuracy, offering a noninvasive diagnostic aid.
Four Oxygenation Trajectories Define Reproducible Clinical Archetypes in Persistent Acute Respiratory Failure
A multi-cohort study identified four reproducible 14-day oxygenation trajectory classes in persistent acute hypoxemic respiratory failure, with distinct mortality, biomarker patterns, and links to ARDS and hyperinflammatory subphenotypes.
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