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This study reveals that COPD poses a greater risk to bone health than T2DM, with combined COPD and T2DM further increasing osteoporosis and fracture risk, especially in men, emphasizing the need for targeted bone health screening.
This article evaluates strategies for interpreting consecutive aldosterone-to-renin ratio tests in primary aldosteronism diagnosis, highlighting the diagnostic trade-offs and guiding clinical decision-making based on discordant or concordan
An explainable machine learning model identifies bariatric surgery candidates at risk for obesity hypoventilation syndrome using seven accessible clinical variables, enhancing early diagnosis and perioperative risk management.
A 5-year real-world cohort study reveals that declines in CGM-derived time in range correlate with increased microvascular complications in type 1 diabetes, offering prognostic value beyond HbA1c.
This report discusses four patients with paternally inherited 15q11.2-q13 duplications linked to MKRN3 overexpression, presenting with delayed puberty and varying degrees of hypogonadism.
Long-read sequencing (LRS) improves genetic diagnosis of Congenital Adrenal Hyperplasia and other DSDs by resolving complex genomic variants, tightening phenotype-genotype correlations, and closing equity gaps in clinical care.
A focused summary of the 2026 international position statement offering practical, safety-first recommendations for continuing or initiating continuous glucose monitoring, insulin pumps, and automated insulin delivery in non‑critically ill
This study highlights how daily feelings of guilt are central drivers of negative emotional burdens in diabetes, influencing emotional well-being and risk of distress and depression.
This study uses longitudinal modeling to compare tirzepatide and semaglutide’s effects on fasting glucose in type 2 diabetes, revealing tirzepatide’s superior control largely due to greater insulin-independent hepatic glucose production sup
This review synthesizes clinical trial evidence showing that PPARγ and GLP1 receptor agonists modulate brain insulin signaling biomarkers in neuropsychiatric and neurodegenerative disorders, revealing CNS-specific metabolic effects beyond p
An international study of 715 pediatric patients with differentiated thyroid carcinoma identifies key predictors of invasive disease and demonstrates stable outcomes despite recent therapy deintensification.
Younger age at type 1 diabetes diagnosis significantly increases risks of mortality, cardiovascular, and kidney complications; each additional year delay in onset reduces these risks. This review synthesizes nationwide cohort findings and c
Empagliflozin consistently reduces major cardiovascular events, heart failure hospitalizations, and mortality across diverse sociodemographic and cardiovascular risk groups in older adults with type 2 diabetes, with especially pronounced ab
This study reveals that lipid profiles paradoxically worsen during the early remission phase after curative surgery for Cushing’s syndrome, highlighting a critical window for cardiovascular risk and targeted intervention.
Radiofrequency ablation (RFA) provides a safe, effective treatment for thyroid nodules in the remaining lobe after unilateral thyroid lobectomy, offering substantial volume reduction with minimal complications and preserved thyroid function
This article reviews the clinical evaluation, differential diagnosis, and treatment outcomes of patients presenting with thyroid compressive symptoms, emphasizing the importance of thorough preoperative workup and individualized surgical se
This study evaluates how different pituitary adenoma histological subtypes influence remission and disease control in acromegaly post-surgery, finding no significant differences though sparsely granulated adenomas show a trend toward lower
A multicenter German registry study comparing carboplatin/paclitaxel to other chemotherapy regimens in anaplastic thyroid cancer found no survival advantage, highlighting the importance of molecular diagnostics and multimodal treatment appr
This study reveals that despite long-term remission in Cushing’s disease, substantial plasma protein abnormalities persist, particularly in coagulation and complement systems, potentially contributing to ongoing health risks.
This study investigates three-year continuous glucose monitoring trajectories across clinical subgroups of adults with type 1 diabetes to identify factors influencing glycemic control and variability, highlighting the need for individualize
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