Section
In 585 RAS-mutated thyroid nodules, distinct molecular and clinical features predict malignancy risk and guide surgical management, with isolated RAS mutations showing low recurrence and potential for conservative care.
Persistent severe vitamin D deficiency during adolescence in girls with idiopathic scoliosis is linked to poorer bone mineral density and compromised bone structure into early adulthood, highlighting the need for targeted interventions.
This comprehensive review synthesizes emerging evidence supporting a new TNM staging system tailored for poorly differentiated thyroid cancer, demonstrating enhanced prognostic accuracy over existing differentiated thyroid cancer models.
This article explores how common genetic variants near SLC2A2 affect glycemic response to glimepiride in type 2 diabetes, highlighting potential for precision medicine in second-line diabetes therapy.
Retatrutide, a triple agonist targeting GIP, GLP-1, and glucagon receptors, demonstrates marked weight loss and improvement in knee osteoarthritis pain and obstructive sleep apnea in adults with obesity in a phase 3 trial.
From 2016 to 2022, gestational and pregestational diabetes prevalence rose alongside severe maternal morbidity in U.S. deliveries, with type 1 diabetes presenting the highest risk for severe complications.
A randomized controlled trial demonstrates that functional inspiratory muscle training integrated with resistance exercise improves functional capacity and respiratory muscle performance in individuals with obesity, complementing benefits f
This large international cohort study clarifies the clinical course, management strategies, and outcomes of ectopic Cushing syndrome, highlighting early biochemical remission as crucial for reducing mortality and complications.
The ENDIA study reveals early alterations in exocrine pancreatic biomarkers, fecal elastase-1 and serum immunoreactive trypsin, in children predisposed to type 1 diabetes, suggesting novel early disease pathogenesis markers.
Bariatric surgery offers substantial 2-year weight loss for patients with obesity who experience intolerable side effects or inadequate response to semaglutide or tirzepatide, with Roux-en-Y gastric bypass demonstrating superior outcomes in
A prospective cohort study identifies three clinical and metabolic subtypes of recent-onset adult type 1 diabetes, revealing distinct disease dynamics, β-cell function trajectories, and complication risks that can guide personalized interve
This Phase 1b trial demonstrates that oral NLRP3 inhibition with ruvonoflast markedly reduces systemic inflammatory biomarkers in obese individuals at elevated cardiovascular risk, with favorable safety and tolerability, supporting further
This study cross-validates resting metabolic rate (RMR) prediction equations in Division I and III collegiate male wrestlers, developing new equations with improved accuracy to guide nutritional and training strategies.
This study demonstrates that physiological concentration platelet fibrin plasma (PFP) is noninferior to supraphysiological platelet-rich plasma (PRP) in healing neuro-ischemic diabetic foot ulcers and other diabetic wounds, offering a simpl
Completion thyroidectomy performed after an interval shows superior parathyroid preservation and lower postoperative hypocalcemia risk compared to initial total thyroidectomy, supporting a staged surgical approach for optimized safety.
The ATTAIN-J trial demonstrated that once-daily oral orforglipron significantly reduced bodyweight with a favorable safety profile in Japanese adults with obesity disease, aligning with global findings on GLP-1 receptor agonists.
The POWER trial assessed a self-directed lifestyle program for patients with OSA and obesity, finding modest improvements in sleep-related quality of life but limited clinically meaningful weight loss over 12 months.
This meta-analysis synthesizes prospective data on sunitinib treatment in metastatic pheochromocytomas and paragangliomas, revealing modest response rates and meaningful disease control with manageable safety profiles.
Sustained VEGF-A suppression via the Port Delivery System with ranibizumab effectively resolves diabetic macular edema with most patients achieving edema normalization; slow resolution may mimic treatment unresponsiveness, warranting reclas
This study evaluates the safety of sodium-glucose cotransporter 2 inhibitors (SGLT2is) versus DPP-4 inhibitors in adults aged 75 and older with type 2 diabetes, demonstrating favorable safety outcomes for SGLT2is without increased harm.
