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Why One Sleep Study May Not Tell the Whole Story: Night-to-Night Variability, AHI Definitions, and OSA Reclassification
A recent Chest study shows that PSG metrics vary unevenly across nights, and AHI scored with 4% desaturation is less stable than AHI 3%/arousal. Hypoxic burden was more reproducible and may better reflect true OSA severity.
Early Neutrophil and Persistent Eosinophil Gene Signatures in Childhood Asthma
A longitudinal blood gene-expression study in children found an early neutrophil-driven immune pattern at age 1, followed by a persistent eosinophilic signature from 4.5 to 10.5 years in those who later developed asthma.
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