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Finerenone May Lower Sudden Death Risk Across the Cardio-Kidney-Metabolic Continuum

A prespecified pooled analysis of 18,991 participants found finerenone was associated with a significant reduction in sudden death across chronic kidney disease, type 2 diabetes, and heart failure populations.

CardiologyJun 10, 2026

SRPK3-Driven TPM1 Splicing Emerges as a Myofilament Mechanism of Diastolic Dysfunction in HFpEF

A Circulation study identifies SRPK3-mediated alternative splicing of TPM1 exon 9a as a driver of myofibrillar disarray, reduced myocardial compliance, and diastolic dysfunction in HFpEF, highlighting a potential disease-modifying therapeut

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Finerenone May Lower Sudden Death Risk Across the Cardio-Kidney-Metabolic Continuum

SRPK3-Driven TPM1 Splicing Emerges as a Myofilament Mechanism of Diastolic Dysfunction in HFpEF

Browse by specialty

Impact of Population-Based Pathogenic Variant Testing on Risk-Based Breast Screening Recommendations: A Secondary Analysis of the WISDOM Study

Millions of Americans Still Live Beyond Timely Reach of Registered Replantation Centers

Serial Dependence in Working Memory Distinguishes Schizophrenia From Bipolar Disorder With Psychosis

Remote Respiratory Therapy Safely Replaced Most Bedside Ventilator Care in a Donor Center ICU

Emergency Medicine Training Must Evolve for a Permanently Crowded, Boarded ED

Telehealth Navigation and Remote Blood Pressure Monitoring Were Linked to Better Hypertension Control in Black Patients at Federally Qualified Health Centers

Primary vs Specialist Palliative Care in End-Stage Liver Disease: Interpreting the 2026 Cluster Randomized Trial in the Broader Evidence Base

The Sieve of Asclepius: A History of Navigating the Medical Literature, From Index to Algorithm

Fludarabine Dose Intensity, Lymphodepletion Biology, and Product-Specific Outcomes in Large B-Cell Lymphoma CAR-T Therapy: Interpreting the 2026 EBMT Registry Analysis