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The clinical briefing

Medical news

8,347 articles

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Oncology

Global Proposal for the TNM Staging System for Poorly Differentiated Thyroid Cancer: A Paradigm Shift in Prognostic Stratification

This comprehensive review synthesizes emerging evidence supporting a new TNM staging system tailored for poorly differentiated thyroid cancer, demonstrating enhanced prognostic accuracy over existing differentiated thyroid cancer models.

Nov 13, 2026
Orthopedics

Enhancing Hip Labral Reconstruction with Acetabular Rim Microfracture: Insights from a Porcine Model

Acetabular rim microfracture during hip labral reconstruction significantly improves graft vascularization, integration, and fibrocartilaginous remodeling, suggesting a promising biological augmentation strategy.

Nov 13, 2026
Orthopedics

Impact of Undernutrition on Outcomes After Dysvascular Major Lower Limb Amputation: Insights from a Longitudinal Study

Undernutrition after dysvascular major lower limb amputation is linked to higher rates of reamputation or mortality, reduced mobility, and poorer quality of life, emphasizing the need for targeted nutritional interventions.

Nov 13, 2026
Oncology

Personalized Impact of Pre-Radiotherapy Tooth Extraction on Osteoradionecrosis Risk in Head and Neck Cancer: Insights from Causal Machine Learning

This study uses causal machine learning to reveal that tooth extraction before radiotherapy neither universally reduces nor increases osteoradionecrosis risk, but individualized effects vary substantially, underscoring the need for patient-

Nov 13, 2026
Cardiology

Evaluating Outpatient CT Coronary Angiography in Acute Chest Pain Post-Myocardial Infarction Rule-Out

A large UK randomized trial found that routine outpatient CT coronary angiography after ruling out myocardial infarction in suspected acute coronary syndrome did not reduce the risk of subsequent cardiac events compared to standard care.

Nov 13, 2026
Gastroenterology

Nurse Practitioner-Led Pathway Slashes Specialist Wait Times by 75% for High-Risk Liver Disease Patients

A new nurse practitioner (NP)-led referral model dramatically accelerates specialist care for patients at risk of advanced liver fibrosis, cutting wai

Nov 12, 2026
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MedTech

Google DeepMind Unveils AlphaGenome 2, Bridging Single-Cell Biology and Genetics to Accelerate Rare Disease and Oncology Breakthroughs

Google DeepMind today announced the launch of AlphaGenome 2 , a next-generation DNA sequence prediction model designed to decode how genetic variation

Nov 12, 2026
Neurology

Pain Perception in Parkinson’s Disease: Insights from Patient Narratives to Improve Care

This qualitative study explores how patients with Parkinson’s disease experience and perceive pain, revealing its complex impact on daily life and emotional well-being, underscoring the need for holistic pain management strategies.

Nov 12, 2026
Clinical Updates

Comparing Piezosurgery and Rotary Burs in Aesthetic Crown Lengthening: A Split-Mouth Randomised Trial

A clinical trial comparing piezosurgery and rotary burs in aesthetic crown lengthening found no significant difference in gingival margin stability, with most changes occurring within the first week post-surgery and stability achieved by si

Nov 12, 2026
Oncology

Ruzaltatug Rezetecan Versus Chemotherapy for EGFR-Mutated Advanced NSCLC Post-EGFR TKI Therapy: Interim Phase 3 HERON-Lung01 Analysis

Ruzaltatug rezetecan, a HER3-directed antibody-drug conjugate, significantly improves progression-free survival over chemotherapy with manageable safety in EGFR-mutated advanced NSCLC progressing after EGFR TKI therapy.

Nov 12, 2026
Pediatrics

Low-Level Pyuria and Antibiotic Prescribing for Suspected Urinary Tract Infection in Children

This study evaluates how low levels of pyuria influence antibiotic prescribing in children with suspected urinary tract infections (UTIs), revealing that minor pyuria often leads to unnecessary antibiotic use.

Nov 12, 2026
Allergy & Immunology

Exploring Blinatumomab as a Novel Therapy for Dermatomyositis and Refractory ANCA-Associated Vasculitis: Insights from a Two-Patient Study

This exploratory study evaluates the safety and efficacy of blinatumomab in treating dermatomyositis and refractory ANCA-associated vasculitis, revealing promising immunological and clinical improvements without serious adverse events over

Nov 12, 2026
Transplantation

Enhancing Mental Health Outcomes in Living Donors: Current Insights and Future Directions

Living donor transplantation demonstrates overall positive mental health outcomes but reveals high-risk subgroups necessitating improved psychosocial assessments and tailored follow-up care to optimize donor wellbeing.

Nov 12, 2026
Dermatology

Long-term Safety and Sustained Control of Atopic Dermatitis in Children Treated with Ruxolitinib Cream: Insights from the Phase 3 TRuE-AD3 Trial

Ruxolitinib cream demonstrates sustained safety and effective disease control over 52 weeks in children aged 2 to 11 years with mild-to-moderate atopic dermatitis, affirming its role as a promising therapeutic option.

Nov 12, 2026
Plastic Surgery

Reducing Donor-Site Complications in DIEP Flap Breast Reconstruction: The Efficacy of Retrorectus Polyglactin Mesh and Personalized Hernia Risk Estimation

This study demonstrates that retrorectus placement of absorbable polyglactin mesh significantly reduces bulge incidence after DIEP flap harvest, with a novel nomogram to personalize hernia risk and guide surgical decisions.

Nov 12, 2026
Critical Care

Unveiling the Long-Term Mortality Burden Among Sepsis Survivors: Insights from a 15-Year Catalonia Cohort Study

A comprehensive 15-year population-based study in Catalonia reveals that over 40% of sepsis survivors die within two years post-discharge, highlighting significant impacts of age, comorbidities, and hospital stay duration on long-term outco

Nov 12, 2026
Anesthesiology

Feasibility and Acceptability of Virtual Reality for Pain Relief During Vaso-occlusive Episodes in Sickle Cell Disease: A Pilot Study

This pilot study assesses the use of virtual reality as a feasible and acceptable non-pharmacologic adjunct to alleviate pain during vaso-occlusive episodes in adults with sickle cell disease.

Nov 12, 2026
Hematology-Oncology

Functional RIG-I in Platelets: A Novel Modulator of Thrombosis During Influenza Infection

This study reveals that the viral RNA sensor RIG-I in platelets modulates thrombotic responses during influenza infection, limiting thrombosis and facilitating immune cell transmigration through a unique signaling pathway.

Nov 12, 2026
Respiratory

Predicting COPD Onset: Validation of a Practical Pre-COPD Scoring System Across Diverse Cohorts

A novel Pre-COPD score, integrating smoking history, symptoms, asthma, and spirometry, robustly predicts incident COPD across three multinational cohorts, enabling early risk stratification and preventive strategies in clinical practice.

Nov 12, 2026
Ophthalmology

Comparative Three-Year Outcomes of Trabeculotomy Versus Combined Trabeculotomy-Trabeculectomy in Primary Congenital Glaucoma with Moderate Corneal Enlargement

A prospective randomized trial shows trabeculotomy is noninferior to combined trabeculotomy-trabeculectomy for 3-year control of intraocular pressure in primary congenital glaucoma with corneal diameter 12-14 mm, providing a less invasive s

Nov 12, 2026
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    Precision Medicine for Long QT Syndrome Type 2: Lumacaftor Corrects Trafficking Defects and Shortens QT Interval

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    Optimizing Postoperative Opioid Prescriptions After Intra-Abdominal Cancer Surgery: Comparing the 5x-Multiplier and 3-Tier Models

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