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Reduced-Intensity Thiotepa Plus Post-Transplant Cyclophosphamide Delivers Near-Universal Engraftment and Minimal GVHD in Matched Sibling Transplantation for Adolescents and Adults With Sickle Cell Disease

A prospective multicenter study reports excellent survival, no graft failure, and very low GVHD with a thiotepa-based reduced-intensity matched sibling transplant platform for severe sickle cell disease.

Hematology-OncologyMay 4, 2026

$Alpha-1-Antitrypsin Emerges as a Potential Salvage Option for Steroid- and Ruxolitinib-Refractory Gastrointestinal Acute GVHD$

Alpha-1-Antitrypsin Emerges as a Potential Salvage Option for Steroid- and Ruxolitinib-Refractory Gastrointestinal Acute GVHD

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Reduced-Intensity Thiotepa Plus Post-Transplant Cyclophosphamide Delivers Near-Universal Engraftment and Minimal GVHD in Matched Sibling Transplantation for Adolescents and Adults With Sickle Cell Disease

Alpha-1-Antitrypsin Emerges as a Potential Salvage Option for Steroid- and Ruxolitinib-Refractory Gastrointestinal Acute GVHD

Browse by specialty

MRD Does Not Consistently Predict PFS Across Modern CLL Trials: Why Surrogacy Depends on Therapy, Duration, and Sample Source

Adding Ipilimumab to Brentuximab Vedotin Plus Nivolumab Did Not Improve Complete Response, but May Prolong Disease Control Without Transplant in Relapsed Hodgkin Lymphoma

Pulmonary Arterial Hypertension Therapy Preserves Gas Exchange Overall in Portopulmonary Hypertension, but New Intrapulmonary Vascular Dilatations Can Emerge

The Impact of Medication Storage Location on Glaucoma Eyedrop Adherence: A Home-Based Assessment Using Electronic Monitoring

MBD4 Germline Variants Mark a Strong Predisposition to Uveal Melanoma, Supporting Broad Genetic Screening

No Clear Winner in Severe Congenital Ptosis Repair: AAO Review Finds Overlapping Efficacy but Distinct Surgical Risks in Children

Ergonomic Strain Is Common in Otolaryngology Surgery, With Pain Rising as Cases Become More Difficult and Prolonged

ACR TI-RADS Reduced Repeat Thyroid Ultrasound but Did Not Lower Biopsy or Surgery Rates in Real-World Practice

Calcitonin Doubling Rate Sharpens Postoperative Recurrence Risk Stratification in Medullary Thyroid Carcinoma With Biochemical Persistent Disease

Laparoscopic Groin Hernia Repair Showed the Lowest Long-Term Operative Recurrence in Medicare Patients, While Robotic Use Expanded Without Clear Recurrence Benefit

Real-World Antibody-Drug Conjugate Outcomes in Gynecologic Cancers Appear Consistent Across Demographic Subgroups

Pregnancy Outcomes Among Individuals With Cerebral Palsy: A Population-Based Cohort Study

Pairing HDV RNA With Anti-HDV Levels May Sharpen Staging and Treatment Monitoring in HBV/HDV Coinfection