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The clinical briefing

Medical news

8,371 articles

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Emergency Medicine

Medical Scribe and Ambient Artificial Intelligence Impact on Emergency Physician Documentation Burden and Clinical Productivity: A Contemporary Evidence Review

This review synthesizes recent evidence demonstrating that both human and ambient AI scribes reduce emergency physician documentation time without diminishing clinical productivity, highlighting evolving technology adoption and future resea

Nov 8, 2026
Internal Medicine

Chronic Care Management in High-Risk Patients: Reducing Acute Care Utilization and Costs Through Coordinated Care

A Johns Hopkins study found that a comprehensive Chronic Care Management program significantly reduced hospitalizations, emergency visits, and acute care costs among high-risk patients, demonstrating the value of coordinated multidisciplina

Nov 8, 2026
Hematology-Oncology

Harnessing CD4+ T Cells: A New Frontier in Targeted Immunotherapy for ALK-Positive T-Cell Lymphoma

This article delineates the pivotal role of CD4+ T cells in mediating immune responses against ALK-positive anaplastic large cell lymphoma, highlighting preclinical evidence supporting immune checkpoint inhibitors as a promising therapeutic

Nov 8, 2026
Oncology

Decoding the Immune Landscape in NSCLC: Oncogene-Specific Spatial Proteomics Identifies Prognostic Niches and Therapeutic Targets

Spatial proteomics reveals how EGFR and KRAS mutations distinctly remodel the immune microenvironment in non-small cell lung cancer, identifying immune niches and prognostic markers that may guide immunotherapy strategies.

Nov 8, 2026
Ophthalmology

Bi-Allelic PRKCZ Loss-of-Function Variants Presenting as Adult-Onset Retinitis Pigmentosa: A Case Series and Functional Characterization

Report of adult-onset retinitis pigmentosa linked to bi-allelic loss-of-function PRKCZ variants, highlighting clinical features, genetic diagnosis, and validation of pathogenic mechanisms.

Nov 8, 2026
Otorhinolaryngology

Early Recognition and Management of Cavernous Sinus Thrombosis: Navigating Diagnostic Challenges and Therapeutic Strategies

This article reviews the clinical presentation, diagnostic challenges, and management strategies for cavernous sinus thrombosis (CST), emphasizing early diagnosis, imaging findings, and the critical role of sinus surgery and anticoagulation

Nov 8, 2026
Gastroenterology

Optimizing Outcomes in Donation After Circulatory Death Liver Transplantation: A Comparative Evaluation of Machine Preservation Techniques

This study evaluates different machine preservation strategies in donation after circulatory death (DCD) liver transplantation, highlighting their impact on graft outcomes, particularly nonanastomotic biliary strictures and survival rates,

Nov 8, 2026
Cardiology

Influence of Cardiometabolic Status on Cardiovascular Effects of Oral Menopausal Hormone Therapy

This review synthesizes evidence from randomized trials indicating that baseline lipid profiles significantly modify coronary heart disease risk associated with oral menopausal hormone therapy, underscoring the importance of lipid assessmen

Nov 8, 2026
Gastroenterology

Decoding HBV Infection Heterogeneity Using B-BEST: Insights from Single-Cell Viral-Host Transcriptomics

B-BEST, a novel single-cell RNA sequencing technique, reveals heterogeneity in HBV-infected hepatocytes, linking viral replication states to host cellular pathways, inflammation, and antiviral responses, with implications for precision HBV

Nov 8, 2026
Neurology

Differences in Epilepsy Etiology, Type, Syndrome, and Severity Between Māori and Non-Māori-Non-Pasifika Children With Epilepsy in New Zealand

This review highlights disparities in epilepsy etiology and severity between Māori and non-Māori-non-Pasifika children in New Zealand, emphasizing socioeconomic and rurality factors driving preventable epilepsy in Māori youth.

Nov 8, 2026
Diabetes & Endocrinology

Unraveling the Heterogeneity of Adult-Onset Type 1 Diabetes: Clinical and Metabolic Subtypes Reveal New Insight for Precision Care

A prospective cohort study identifies three clinical and metabolic subtypes of recent-onset adult type 1 diabetes, revealing distinct disease dynamics, β-cell function trajectories, and complication risks that can guide personalized interve

Nov 8, 2026
Cardiology

Targeting Inflammation in Cardiovascular Risk: Efficacy and Safety of Oral NLRP3 Inhibitor Ruvonoflast

This Phase 1b trial demonstrates that oral NLRP3 inhibition with ruvonoflast markedly reduces systemic inflammatory biomarkers in obese individuals at elevated cardiovascular risk, with favorable safety and tolerability, supporting further

Nov 8, 2026
Rehabilitation Medicine

Precision in Energy Expenditure: Validating and Refining Resting Metabolic Rate Equations for Collegiate Male Wrestlers

This study cross-validates resting metabolic rate (RMR) prediction equations in Division I and III collegiate male wrestlers, developing new equations with improved accuracy to guide nutritional and training strategies.

Nov 8, 2026Sign in to read
Neurology

Bridging the Knowledge Gaps in Traumatic Brain Injury Recovery Among Australians: A Synthesis of Evidence and Implications for Practice

Despite reasonable understanding of concussion mechanisms, Australians demonstrate significant gaps in knowledge about recovery following traumatic brain injury, underscoring the need for targeted education to improve rehabilitation engagem

Nov 8, 2026
Dentistry

Enhancing Routine Dental Visits in Adults: Insights from the RETURN Randomized Controlled Trial

The RETURN trial demonstrated that a nurse-led behavioral intervention modestly increased planned dental visits and reduced dental anxiety among adults attending urgent dental care, particularly benefiting socioeconomically disadvantaged gr

Nov 8, 2026
Oncology

Perioperative Durvalumab and Enfortumab Vedotin Regimens Enhance Outcomes in Muscle-Invasive Bladder Cancer

A pivotal phase 3 trial demonstrates improved event-free and overall survival with perioperative durvalumab combined with neoadjuvant enfortumab vedotin, with or without tremelimumab, versus surgery alone in muscle-invasive bladder cancer p

Nov 8, 2026
Dentistry

Enhanced Palatal Donor-Site Healing with Chitosan and Injectable PRF: Insights from a Randomized Clinical Trial

This RCT demonstrates that chitosan sponges, especially when enriched with injectable platelet-rich fibrin, significantly improve palatal wound healing and patient comfort following free gingival graft harvesting compared to gelatine sponge

Nov 7, 2026
Critical Care

Evaluating Prone Positioning and High-Frequency Oscillatory Ventilation in Pediatric ARDS: Insights from the PROSpect Trial

The PROSpect trial found no improvement in ventilator-free days with prone positioning or HFOV compared to conventional ventilation in children with moderate-to-severe PARDS, cautioning against their routine first-line use due to safety con

Nov 7, 2026
Pediatrics

Impact of Caregiver Mental Health on the Efficacy of Parenting Interventions in Rural China

This study reveals that a parenting intervention improved child cognitive and language development primarily when caregivers exhibited no baseline mental health symptoms, highlighting the moderating role of caregiver mental health in early

Nov 7, 2026
Rheumatology

Optimizing Referral Triage to Identify Inflammatory Rheumatic and Musculoskeletal Diseases: Validation and Implications

A novel triage approach combining telephone screening and brief rheumatologist consultation effectively prioritizes patients with inflammatory rheumatic diseases, shortening wait times and improving resource allocation while underscoring th

Nov 7, 2026
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  4. 04Cardiology

    Precision Medicine for Long QT Syndrome Type 2: Lumacaftor Corrects Trafficking Defects and Shortens QT Interval

  5. 05General Surgery

    Optimizing Postoperative Opioid Prescriptions After Intra-Abdominal Cancer Surgery: Comparing the 5x-Multiplier and 3-Tier Models

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