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This study introduces a standardized 5-class framework for tau PET imaging to better detect and stage Alzheimer’s disease, improving early diagnosis and patient stratification across different tracers.
This study uses longitudinal modeling to compare tirzepatide and semaglutide’s effects on fasting glucose in type 2 diabetes, revealing tirzepatide’s superior control largely due to greater insulin-independent hepatic glucose production sup
This review synthesizes clinical trial evidence showing that PPARγ and GLP1 receptor agonists modulate brain insulin signaling biomarkers in neuropsychiatric and neurodegenerative disorders, revealing CNS-specific metabolic effects beyond p
An international study of 715 pediatric patients with differentiated thyroid carcinoma identifies key predictors of invasive disease and demonstrates stable outcomes despite recent therapy deintensification.
Younger age at type 1 diabetes diagnosis significantly increases risks of mortality, cardiovascular, and kidney complications; each additional year delay in onset reduces these risks. This review synthesizes nationwide cohort findings and c
Empagliflozin consistently reduces major cardiovascular events, heart failure hospitalizations, and mortality across diverse sociodemographic and cardiovascular risk groups in older adults with type 2 diabetes, with especially pronounced ab
A gene-specific, risk-based screening algorithm for relatives with titin-truncating variants optimizes monitoring intervals from 1 to 5 years, improving safety and resource use in dilated cardiomyopathy surveillance.
The SUSTAIN-IT study reveals variable improvements in health-related quality of life over two years following heart transplantation or long-term mechanical circulatory support in older heart failure patients, highlighting important consider
This study identifies plasma proteomic signatures linked to clonal hematopoiesis driver mutations and develops a proteomic risk score that independently predicts adverse clinical outcomes in heart failure with preserved ejection fraction (H
A large multicenter study shows that balanced crystalloids administered before ICU admission in sepsis patients reduce 30-day mortality compared to saline, supporting early fluid choice’s impact on sepsis outcomes.
This study analyzes the rising incidence and prevalence of non-infectious pediatric uveitis in the United States, detailing demographic distributions, ocular complications, systemic associations, and treatment patterns from 2016 to 2025 usi
Centralized multidisciplinary retinoblastoma care incorporating telemedicine and international partnership at KHCC improved survival and globe salvage rates to levels comparable with high-income countries, demonstrating a scalable model for
Lymphovascular invasion independently predicts worse overall survival in surgically treated laryngeal squamous cell carcinoma, influencing postoperative risk stratification and adjuvant therapy decisions.
Proteinuria levels in women with preterm pre-eclampsia correlate strongly with pregnancy latency and maternal adverse outcomes but not perinatal outcomes, providing useful prognostic information comparable to angiogenic biomarkers.
This review synthesizes evidence on the cost-effectiveness of standalone salpingectomy for ovarian cancer prevention, highlighting its benefits primarily in women at moderately elevated risk, especially between ages 45-50, supporting tailor
Higher whole-grain intake consistently improves multiple cardiometabolic risk factors, with optimal benefits at 60–100 g/day. Evidence highlights reductions in adiposity, blood lipids, inflammation, glucose, and blood pressure, supporting w
This study evaluates risk factors for intracranial haemorrhage after tenecteplase fibrinolysis in STEMI patients, developing a prediction model highlighting age, blood pressure, sex, weight, and dose interactions as key determinants.
Use of EMS equipment in the ED is associated with shorter time to rhythm analysis and defibrillation for OHCA patients, potentially improving early resuscitation outcomes.
This study reveals coordinated cellular programs underlying response and resistance to neoadjuvant PD-L1 blockade in ESCC, highlighting potential combinatorial immunotherapy targets for personalized treatment strategies.
This study delineates how vascular imaging morphologies, notably the double lumen sign, predict time-specific recurrence risk after craniocervical artery dissection, highlighting the hyperacute phase as critical for secondary prevention.
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