Latest news
5033 articles · 20 / page
A Novel Approach to Targeting DLL3 with Tarlatamab in a Patient with Medullary Thyroid Carcinoma after Progression on Selpercatinib
This case report details successful management of RET-altered medullary thyroid carcinoma using tarlatamab after selpercatinib progression, highlighting modified dosing to mitigate toxicities and achieve complete response.
Rotational Chair vs. Manual Maneuvers for Non-Complex BPPV: An Evidence-Based Review and Clinical Synthesis
This review synthesizes evidence comparing rotational chair therapy and manual maneuvers in uncomplicated BPPV, highlighting comparable efficacy, quality-of-life improvements, and patient-specific considerations for recurrence and treatment
Multiple Sclerosis Does Not Appear to Worsen In-Hospital Outcomes After Cardiovascular Surgery, but Routine Home Discharge Is Less Common
A large US inpatient analysis found similar in-hospital mortality and complication rates after cardiovascular surgery in patients with and without multiple sclerosis, but patients with MS were less often discharged routinely home.
Blood Cancer Proteins Plus Histoplasma Antibodies Improve Malignancy Assessment in Indeterminate Pulmonary Nodules
In two US cohorts, combining serum cancer biomarkers and Histoplasma antibodies with the Mayo model improved discrimination of benign versus malignant pulmonary nodules, especially in intermediate-risk cases.
Pelvic Exenteration for Recurrent Cervical Cancer Can Deliver Long-Term Survival, but Survivorship Burden Remains Substantial
A mixed-methods study suggests pelvic exenteration offers meaningful long-term survival in selected patients with recurrent cervical cancer, while qualitative data reveal persistent physical, social, and sexual burdens that standardized qua
Pregnancy in Women With Vascular Malformations Carries High Risks of Postpartum Hemorrhage and Symptom Worsening, While Thromboembolism Clusters in Extensive Lower-Extremity Disease
A nationwide Dutch study suggests pregnancy in women with peripheral vascular malformations is frequently complicated by symptom progression and postpartum hemorrhage, with venous thromboembolism concentrated in extensive lower-extremity ma
Post-infection Gut-Brain Disorders Affect About 1 in 10 People With DGBI Worldwide, With Distinct Psychological and Regional Patterns
A large 26-country survey found that post-infection disorders of gut-brain interaction account for 10.5% of DGBI cases and are linked to younger age, male sex, urban living, anxiety, and greater somatic symptom burden.
PRDM9 Deficiency Identifies a Predominant Molecular Subgroup in Sporadic Hirschsprung Disease and Enables Blood-based Risk Stratification
A 2026 Gastroenterology study links PRDM9 deficiency to ectopic DNA breaks, mosaic promoter deletions, and impaired enteric neuronal differentiation in sporadic Hirschsprung disease, while introducing a blood-based molecular score that impr
Ultra-Early Remote Ischemic Postconditioning After Thrombectomy Appears Safe but Does Not Improve 90-Day Stroke Recovery
In the EnTRIPS randomized trial, ultra-early remote ischemic postconditioning after successful endovascular thrombectomy was safe but did not significantly improve 90-day functional independence in acute ischemic stroke.
Postmenopausal Migraine Signals Higher Ischemic Stroke Risk, Not Hemorrhagic Stroke, in the Women’s Health Initiative
In a large cohort of postmenopausal women, migraine history was associated with a modest increase in ischemic stroke risk over 20 years, while total and hemorrhagic stroke risks were not significantly elevated.
Hypertension-Related High-Risk Features May Identify Which Patients With Cryptogenic Stroke Benefit From Apixaban Instead of Aspirin
An exploratory ARCADIA analysis suggests that patients with cryptogenic stroke and atrial cardiopathy without severe hypertension-related features may derive greater benefit from apixaban than aspirin, whereas those with high-risk hypertens
A Novel Approach to Targeting DLL3 with Tarlatamab in a Patient with Medullary Thyroid Carcinoma after Progression on Selpercatinib
A 64-year-old man with RET-altered medullary thyroid carcinoma who progressed on selpercatinib achieved complete response after modified dosing of tarlatamab with manageable CRS/ICANS.
A Three-miRNA Plasma Signature May Help Detect Early Beta Cell Dysfunction Before Overt Type 2 Diabetes Progression
Plasma profiling identified a three-miRNA panel associated with beta cell rate sensitivity across glucose tolerance stages, suggesting a minimally invasive approach to detect early insulin secretory decline.
Culture-Negative Infective Endocarditis in the Modern Diagnostic Era: Patient Characteristics and Heterogeneity in a Nationwide Cohort
A nationwide Danish study found that culture-negative infective endocarditis was less common than previously reported, often presented without fever or sepsis, and showed higher embolic risk. PET-CT was especially useful in prosthetic valve
Silent Plaque Ruptures in Non-Obstructive Lesions of Non-Infarct-Related Arteries: What Serial Coronary Imaging Reveals
In patients with acute myocardial infarction, silent plaque rupture was found in 12% of non-obstructive lesions in non-infarct-related arteries. Larger plaques, positive remodeling, and thinner fibrous caps were linked to rupture, and more
Low-Level Airborne Particulate Matter and Risk of Hypertension Hospitalization in Older U.S. Adults
A large U.S. study found that even PM2.5 levels below current federal standards were linked to higher hypertension hospitalization risk in older adults, especially among women and some regional and socioeconomic groups.
Individual GLP-1 Receptor Agonists and SGLT2 Inhibitors Show Largely Comparable Cardiovascular Protection in Type 2 Diabetes
A multinational real-world study found broadly similar cardiovascular effectiveness across individual GLP-1 receptor agonists and SGLT2 inhibitors in metformin-treated type 2 diabetes, including among patients with established cardiovascula
Exploring the Impact of Body Mass Index on Heart Failure Outcomes: Insights from Mendelian Randomization
This study leverages Mendelian randomization to demonstrate that genetically elevated BMI is associated with increased mortality and adverse cardiovascular outcomes in heart failure, irrespective of ejection fraction status, underscoring po
Oral NLRP3 Inhibition With Ruvonoflast Produces Rapid, Reversible Suppression of Residual Inflammation in Adults at High Cardiovascular Risk
In a Phase 1b placebo-controlled trial, ruvonoflast markedly reduced hsCRP, IL-6, and fibrinogen over 28 days in adults with obesity, elevated hsCRP, and cardiometabolic risk, supporting further evaluation of oral NLRP3 inhibition in athero
Low-Level Airborne Particulate Matter and Risk of Hypertension Hospitalization in Older U.S. Adults
Among more than 26 million older U.S. adults, even PM2.5 levels below current standards were linked to higher hypertension hospitalization risk, suggesting no clearly safe low-exposure threshold.
Browse by specialty
Open language-specific specialty feeds and department pages.