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Vaginal Hysterectomy Versus Vaginal Assisted Natural Orifice Transluminal Endoscopic Surgery Hysterectomy: Results of a Randomized Controlled Trial
A randomized trial found vaginal assisted NOTES hysterectomy improved same-day discharge, operative time, and blood loss versus standard vaginal hysterectomy, without increasing complications or affecting recovery.
Trends and Characteristics of Inpatient versus Ambulatory Surgery for Endometriosis
A U.S. national study found endometriosis surgery is shifting from inpatient to outpatient care, with hospital cases more common in older, medically complex patients and those with more extensive disease.
Severe Surgical Complications During Cesarean Delivery Are Linked to Higher Postpartum Readmission Risk
Severe surgical complications during cesarean delivery were linked to about twice the risk of postpartum readmission within 42 days, especially for wound infection, supporting closer follow-up after complicated births.
PBC-AIH Variant: New International Consensus Clarifies Diagnosis and Treatment
An international Delphi panel has standardized how to define, diagnose, and treat the PBC-AIH variant, emphasizing liver biopsy, periodic reassessment, and tailored immunosuppression for worse-risk patients.
KRAS-Driven CLDN18.2 O-GlcNAcylation Promotes Pancreatic Cancer Progression and Therapy Resistance
KRAS mutation and high glucose promote O-GlcNAcylation of CLDN18.2 in pancreatic cancer, pushing the protein off the cell membrane, boosting metastasis, and weakening CLDN18.2-targeted therapy. Low-dose MRTX1133 may restore sensitivity.
Prior Myocardial Infarction and Cognitive Decline: Insights from the REGARDS Cohort
In the REGARDS cohort, prior myocardial infarction, including silent MI, was linked to faster long-term cognitive decline, suggesting heart attack history may help identify people at risk for future cognitive impairment.
Safety and Outcomes of Dabigatran Reversal With Idarucizumab Before IV Thrombolysis in Acute Ischemic Stroke
Real-world registry data suggest that reversing dabigatran with idarucizumab before IV thrombolysis in acute ischemic stroke is safe and yields outcomes similar to patients not on oral anticoagulants.
Effects of Exercise and Intensive Vascular Risk Reduction on Cognitive Function in Older Adults: A Randomized Clinical Trial
A 24-month randomized trial found that exercise, intensive blood pressure and cholesterol control, or both together did not significantly improve cognitive function in older adults at increased risk for dementia.
TSH Stimulation Methods Show Comparable Outcomes in Radioiodine-Avid Metastatic Differentiated Thyroid Cancer
In radioiodine-avid metastatic differentiated thyroid cancer, rhTSH and mixed rhTSH/thyroid hormone withdrawal preparation produced comparable adjusted outcomes. Prognosis was driven mainly by metastatic burden and age, supporting individua
Immune-Cell Transcriptomics and Mendelian Randomisation Identify New Causal Genes for Type 2 Diabetes Complications
This study used immune-cell gene expression and genetic analyses to identify causal genes and immune pathways linked to type 2 diabetes and its complications, highlighting diabetic neuropathy as a distinct cluster and prioritising ten promi
Retatrutide Produces Broad Favorable Shifts in Fatty Acid Oxidation and Insulin Resistance Biomarkers in Obesity With or Without Type 2 Diabetes
Post-hoc metabolomic and lipidomic analyses from two phase 2 trials suggest retatrutide favorably remodels metabolic pathways linked to fatty acid oxidation, insulin resistance, and triglyceride composition in obesity, with and without type
Improving the Algorithm: Adding a Socioeconomic Measure to Predict Type 2 Diabetes in Youth With Prediabetes
Adding the Area Deprivation Index to HbA1c improved prediction of type 2 diabetes within 1 year in youth with prediabetes, highlighting the importance of socioeconomic factors in diabetes risk.
Safety of Biopsy in Pheochromocytoma and Paraganglioma: What a Global Study Found
This international study found that biopsy of pheochromocytoma and paraganglioma had low mortality and low serious complication rates, suggesting biopsy may be reasonable in carefully selected patients with expert management.
Heart Failure Medication Adherence Depends Less on Motivation Than on Whether Treatment Fits Daily Life
A qualitative study in heart failure shows that medication adherence is shaped by regimen complexity, diuretic burden, psychosocial stressors, cost, and care coordination rather than motivation alone.
Beyond Neuronal Injury: Serum Neurofilament Light Chain as a Prognostic Biomarker for Cardiovascular Outcomes in Atrial Fibrillation
This review analyzes the landmark SWISS-AF study, demonstrating that serum neurofilament light chain (sNfL), traditionally a marker of neuronal damage, is a potent independent predictor of major vascular events, heart failure, and mortality
Cardiovascular Benefit of CPAP May Be Greater in High-Risk Obstructive Sleep Apnoea
This pooled analysis found that CPAP may lower cardiovascular event risk mainly in patients with high-risk obstructive sleep apnoea, especially those with stronger heart-rate surges or greater oxygen deprivation during sleep.
Drug-Eluting Resorbable Scaffold Maintains a 3-Year Patency Advantage Over Angioplasty in Infrapopliteal CLTI
Three-year LIFE-BTK data show sustained patency and reintervention benefits with a drug-eluting resorbable scaffold versus angioplasty in selected patients with infrapopliteal CLTI, with comparable limb salvage and safety.
Laroprovstat, the First Oral Small-Molecule PCSK9 Inhibitor for Hypercholesterolemia: Results From a Phase 1 Trial
Laroprovstat, an investigational oral PCSK9 inhibitor, was well tolerated and produced substantial LDL cholesterol reductions, especially when combined with rosuvastatin, supporting further development for hypercholesterolemia.
Age-Dependent Interplay of Modifiable Risk Factors and Genetic Risk in Pancreatic Cancer
A UK Biobank study found that lifestyle-related pancreatic cancer risks were strongest in younger adults, especially those with high genetic risk, supporting early prevention efforts.
Patient-Derived Neuronal Synapse Deficits Predict Brain Network Abnormalities and Cognitive Impairment in Schizophrenia
A multimodal translational study links genetically driven synaptic deficits in patient-derived neurons to cortical structure, electrophysiology, and cognition in schizophrenia, supporting biologically informed stratification of cognitive im
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