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Elamipretide Restores Skeletal Muscle Performance in a HFpEF Rat Model by Stabilizing Mitochondria
In a HFpEF rat model, Elamipretide improved muscle force, reduced titin abnormalities, and prevented atrophy, supporting cardiolipin stabilization as a potential strategy for exercise intolerance.
Can a Mitochondrial “Membrane Stabilizer” Restore Muscle Function in HFpEF? New Rat Data on Elamipretide
In a HFpEF rat model, elamipretide improved skeletal muscle force, reduced titin hyperphosphorylation, and prevented atrophy, supporting cardiolipin stabilization as a promising metabolic strategy.
Cardiolipin Stabilization Revives Skeletal Muscle Performance in a Preclinical HFpEF Model
In a rat model of HFpEF, the mitochondrial-targeted peptide elamipretide improved skeletal muscle force, reduced atrophy, and normalized titin phosphorylation, supporting cardiolipin stabilization as a promising mechanism.
Pregnancy-Associated SCAD in Focus: What the iSCAD Registry Reveals About a Rare but High-Stakes Cause of MI in Women
The iSCAD Registry study highlights distinctive reproductive and psychosocial features among women with pregnancy-associated SCAD, underscoring the need for individualized counseling, heightened diagnostic suspicion, and multidisciplinary f
Blood DNA Methylation Maps Atherosclerosis Across Vascular Beds: Strong Signals, but Mostly a Record of Cumulative Risk Exposure
In 2 prospective cohorts, blood DNA methylation was associated with carotid, coronary, and peripheral atherosclerosis, but most signals overlapped with smoking and cardiometabolic risk factors rather than vessel-specific biology.
Can a Sirolimus-Eluting Balloon Reduce Stent Use in De Novo Coronary Disease? New Randomized Evidence from SELUTION DeNovo
A large randomized trial found sirolimus-eluting balloon with provisional stenting noninferior to routine DES at 1 year by intention-to-treat analysis, though repeat revascularization was slightly higher and per-protocol noninferiority was
Can a Sirolimus-Eluting Balloon Strategy Rival Routine Stenting in De Novo Coronary Lesions? New Randomized Trial Says Maybe
An SEB plus provisional stenting strategy was noninferior to routine DES at 1 year for target vessel failure, but repeat revascularization was modestly higher and per-protocol noninferiority was not confirmed.
Avelumab Plus Methotrexate in Low-Risk Gestational Trophoblastic Tumors: A Promising First-Line Signal From TROPHAMET
TROPHAMET found that first-line avelumab plus methotrexate achieved 96.2% hCG normalization in low-risk gestational trophoblastic tumors with manageable toxicity, no relapses at 41 months, and preserved fertility.
Restoring Physiology After Upper Extremity Amputation: What the First Human AMI Reconstruction Experience Suggests
A small human cohort study suggests that upper extremity amputation with AMI reconstruction is feasible and may preserve residual limb volume, improve muscle mechanics, and reduce pain and phantom limb symptoms.
Earlier ADHD Diagnosis May Mark a Better Educational Trajectory: What a Finnish Registry Study Found
In a nationwide Finnish cohort, earlier ADHD diagnosis was linked to better school performance, more academic progression, and less dropout than diagnosis closer to age 16, especially before educational track selection.
When the ICU Trauma Lingers: How Family PTSD Symptoms Build Across the Critical Illness Journey
Qualitative interviews show family PTSD after ICU care is shaped by cumulative stressors across the illness trajectory, highlighting the need for continuous, family-centered communication and support.
A New Bedside Twist on Passive Leg Raising: PPV Change Predicts Fluid Responsiveness During Pressure Support Ventilation
In PSV patients, passive leg raising–induced PPV change predicted preload responsiveness, especially when inspiratory effort was low by P0.1.
When Language Becomes a Safety Risk: English Proficiency and Hospital Restraint Practices
A large single-center study found that hospitalized patients with limited English proficiency had higher adjusted odds of physical restraint or antipsychotic use, especially when delirium was present, raising concerns about communication-dr
Prompt and Intensive Antiviral Chemoprophylaxis in Nursing Home Influenza Outbreaks: Evidence Synthesis and Clinical Implications
Intensive oseltamivir chemoprophylaxis for ≥70% of nursing home residents within 2 days of influenza outbreak reduces hospitalization risk, underscoring prompt antiviral intervention as a critical outbreak control strategy.
Early, Broad Oseltamivir Prophylaxis May Cut Hospitalizations in Nursing Home Influenza Outbreaks
Prompt oseltamivir prophylaxis covering at least 70% of eligible nursing home residents within 2 days of outbreak detection was associated with fewer hospitalizations, but not lower mortality.
Fast, Broad Oseltamivir Use in Nursing Home Flu Outbreaks May Cut Hospitalizations
In a real-world target trial emulation, starting oseltamivir prophylaxis within 2 days for at least 70% of eligible nursing home residents was linked to fewer hospitalizations, but not lower short-term mortality.
Laterality of Swimming-Induced Pulmonary Edema During Combat Sidestroke: Comparative Insights from Lung Ultrasound and Chest Radiography
This review synthesizes evidence on SIPE lateralization corresponding to dependent body position during combat sidestroke, highlighting moderate concordance between lung ultrasound and chest x-ray findings and implications for field diagnos
Mepolizumab and Blood Eosinophil Variability in COPD: A New Dimension in Targeted Therapy
This article reviews mepolizumab efficacy in COPD patients with variable blood eosinophil counts, showing benefits even with intermittent eosinophilia, expanding treatable phenotypes beyond persistent elevation.
Optimized AAV5-RPGR Gene Therapy Rescues Photoreceptor Integrity and Function in X-Linked Retinitis Pigmentosa Mouse Model
An optimized AAV5 vector delivering a stabilized human RPGR ORF15 gene significantly restores photoreceptor structure and function in RPGR-deficient mice, demonstrating a promising gene therapy for X-linked retinitis pigmentosa.
Familial Patterns of Strabismus and Subnormal Stereopsis in Parents of Affected Children: Implications for Genetic Research
A large prospective study reveals high prevalence of strabismus and decreased stereopsis in parents of children with strabismus, underscoring familial inheritance and subclinical phenotypes useful for genetic studies.
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