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Commercially Insured Patients Wait a Median of 25 Days for New Neurology Care, with Regional and Plan-Based Differences
Among 114,034 commercially insured patients, the median time to a new neurology visit was 25 days. Waits varied by sex, diagnosis, region, and plan type, while neurologist density showed no association with access.
Neurofilament Light Chain Reveals Rapid Neuroaxonal Injury in New-Onset Refractory Status Epilepticus
In a multinational cross-sectional study, serum and CSF neurofilament light chain—unlike S100B—tracked severe acute brain injury in cryptogenic NORSE, rose rapidly over the first 3 weeks, and predicted poor short-term outcome, supporting ur
ATA Guideline Updates Reduced Thyroid Cancer Overtreatment in a 31,861-Patient South Korean Cohort
A large South Korean cohort found ATA-guideline de-escalation reduced total thyroidectomy, RAI use, and permanent hypocalcemia in papillary thyroid carcinoma, without significant loss of 5-year disease-free survival.
Oral Glucose Absorption Enhanced in Early Metabolic Dysfunction-Associated Steatotic Liver Disease
New research reveals accelerated glucose absorption in early MASLD patients, independent of gastric emptying. This metabolic alteration may drive liver disease progression before hepatic insulin resistance develops.
Early MASLD Is Associated With Enhanced Oral Glucose Absorption Independent of Gastric Emptying
Stable-isotope OGTT data suggest that early MASLD is linked to higher oral glucose absorption, independent of gastric emptying, with preserved hepatic insulin suppression but impaired peripheral glucose clearance.
ATTR-CM Is Often Diagnosed Years After Heart Failure in Medicare Patients
In Medicare beneficiaries, ATTR-CM was diagnosed a median 494 days after heart failure and 840 days after loop diuretic initiation, with delays more common in women and patients with several common comorbidities.
Standard-Dose DOACs Outperform Warfarin More Strongly in Asian Than Non-Asian Patients With Atrial Fibrillation
In a patient-level meta-analysis of 10,212 Asian and 61,471 non-Asian AF patients, standard-dose DOACs outperformed warfarin more strongly in Asians, with less stroke, major bleeding, and net clinical harm. Standard-dose therapy was favored
Coronary Stent Trial Site Selection Could Narrow Racial Gaps in Enrollment, but Women Remain Underrepresented
In nine U.S. coronary stent PMA trials, minority participants were markedly underrepresented, while women were modestly underrepresented. Site geography and surrounding county demographics predicted minority enrollment, suggesting targeted
Fontan Outcomes Network Enrolls 1,121 Patients and Reveals a High Burden of Arrhythmia, Thrombosis, and Mental Health Needs
Background Fontan palliation has transformed the prognosis of children born with single-ventricle heart disease, allowing...
New Cervical Cancer Screening Guidelines: Patient-Collected HPV Tests Now Recommended
Introduction and Context Despite being highly preventable, cervical cancer remains a significant health threat. The...
CD276 Identified as Key Driver of Chemoresistance in Advanced Pancreatic Cancer
Single-cell analysis reveals CD276/B7-H3 as a critical regulator of chemoresistance in pancreatic ductal adenocarcinoma, highlighting its dual role in promoting basal-like tumor states and immune evasion.
Intracranial Hemorrhage Patterns and Outcomes in Minor Stroke: Insights from the TEMPO-2 Trial
Secondary analysis of TEMPO-2 trial data reveals intracranial hemorrhage in minor stroke patients increases 90-day mortality risk threefold, with higher hemorrhage rates in tenecteplase-treated patients despite most bleeds being non-symptom
Superior Efficacy of Cenobamate in Drug-Resistant Focal Epilepsy: Real-World Evidence
This article reviews a large real-world study demonstrating cenobamate’s superior effectiveness over brivaracetam, lacosamide, and perampanel in reducing seizures for adults with drug-resistant focal epilepsy.
Microplastics in Human Thyroid: A Potential Trigger for Autoimmune Thyroiditis
Microplastics detected in thyroid tissues show higher concentrations in autoimmune thyroiditis patients, suggesting a potential environmental link to thyroid autoimmunity.
Ethnicity, Migration, and Mental Health: Independent Risk Factors Persist in Type 2 Diabetes Disparities
A cohort study reveals persistent ethnic disparities in type 2 diabetes risk, with migration status and mental health conditions as independent contributors, highlighting unmet needs in addressing structural determinants of health inequalit
AI-Driven Insights into Incidental Thyroid Findings: Prevalence, Clinical Impact, and the Overdiagnosis Dilemma
A retrospective cohort study using AI to analyze radiology reports reveals high prevalence of incidental thyroid findings, strong association with diagnostic cascades, and potential overdiagnosis of low-risk thyroid cancers.
Intermittent Lifestyle Physical Activity: A Promising Strategy for Type 2 Diabetes Prevention
Brief, intermittent bouts of moderate- to vigorous-intensity physical activity during daily routines may significantly reduce the risk of type 2 diabetes in adults who do not engage in leisure-time exercise.
Real-Time CGM Outperforms SMBG in Glycemic Control for Type 2 Diabetes on Basal Insulin Plus Modern Therapies
The FreeDM2 trial demonstrates that real-time CGM significantly improves HbA1c levels compared to SMBG in adults with type 2 diabetes on basal insulin and modern therapies, with sustained benefits over 32 weeks.
Elevated Heart Failure Risk in People With HIV: Insights from the REPRIEVE Trial
The REPRIEVE trial reveals higher heart failure incidence in people with HIV, particularly among women, Black participants in high-income regions, and those with hypertension or obesity. Traditional risk factors, not HIV-specific markers, w
Burst Exercise Testing Outperforms Traditional Bruce Protocol in CPVT Diagnosis and Management
A new study shows that the Burst exercise stress test is more effective than the traditional Bruce protocol in detecting arrhythmias in CPVT patients, leading to better treatment decisions without safety concerns.
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