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This article evaluates spinal MRI features in AQP4-IgG+ NMOSD myelitis, highlighting the diagnostic specificity of bright spotty lesions, the double-contoured LETM sign, and sagittal ring enhancement for differentiating NMOSD from other mye
This study highlights how daily feelings of guilt are central drivers of negative emotional burdens in diabetes, influencing emotional well-being and risk of distress and depression.
Between 2015 and 2025, non-cystic fibrosis bronchiectasis prevalence in the US primary care population increased by 133%, predominantly affecting older, white, female patients with Medicare coverage.
Quantitative CT-defined mucus plugs combined with emphysema severity stratify COPD patients into distinct subtypes that predict risk of acute exacerbations, enabling personalized risk assessment and targeted preventive strategies.
This review synthesizes evidence on persistent excess mortality after SARS-CoV-2 infection in people with severe mental illness (SMI) during and following COVID-19 vaccination roll-out in England, highlighting disparities in mortality risk
This statewide cohort study reveals significantly higher incidence and earlier onset of systemic physical multimorbidity among people with schizophrenia-spectrum or bipolar disorders compared to matched controls, highlighting urgent needs f
This large-scale meta-analysis identifies specific brain structural alterations—mainly in cortical surface area and subcortical volumes—associated with bulimia nervosa diagnosis and symptom severity, advancing understanding of its neurobiol
A Danish cohort study reveals decreased genetic risk profiles in recent ASD and ADHD diagnoses, supporting broader diagnostic criteria as a driver of rising incidence rates.
A phase 2 randomized trial found that ilofotase alfa did not significantly reduce kidney injury or improve outcomes in high-risk patients undergoing on-pump cardiac surgery, though it was safe and well tolerated.
This nationwide Swedish study tracks shifting predictors of critical illness during different COVID-19 pandemic periods and compares them to seasonal influenza, highlighting vaccination status and age as key risk factors for severe outcomes
This study analyzes the epidemiology, treatment processes, and outcomes of critically ill cirrhosis patients undergoing continuous renal replacement therapy, highlighting high mortality rates, anticoagulation practices, and implications of
This review synthesizes evidence on the relationship between antipsychotic choice after traumatic brain injury (TBI) and post-traumatic epilepsy risk in older adults, highlighting recent population-based findings and mechanistic implication
This randomized clinical trial demonstrates no clinically meaningful difference in pain relief between 20 mg intranasal and subcutaneous ketamine for acute musculoskeletal trauma in the emergency department, with minor adverse events being
This randomized trial found that larger doses of bupivacaine for sphenopalatine ganglion block did not improve sustained headache relief in emergency patients compared to smaller doses, with good tolerability across all doses.
This review synthesizes evidence on produce prescription dosing, highlighting a randomized trial demonstrating dose-dependent improvements in redemption, food security, and fruit/vegetable intake, contextualized within the evolving literatu
Removal of Medicaid prescription caps in South Carolina improved antiretroviral therapy adherence and HIV medication fills among people with HIV, though no significant health care utilization changes were noted, suggesting need for compleme
A nationwide survey of hospitalists reveals varied beliefs regarding treatment thresholds and approaches for asymptomatic elevated blood pressure in hospitalized patients, highlighting clinical uncertainty and practice variation.
This review assesses the clinical utility of steatotic liver disease risk scores in predicting cirrhosis and hepatocellular carcinoma, highlighting the superior performance of the SAFE score for cirrhosis and challenges in HCC risk predicti
This study elucidates the incidence and characteristics of respiratory viral infections (RVIs) within 100 days following hematopoietic cell transplant and CAR T-cell therapy, highlighting SARS-CoV-2 as the predominant pathogen and identifyi
The addition of tyrosine kinase inhibitors to intensive chemotherapy markedly improves remission rates and overall survival in patients with de novo BCR::ABL1+ acute myeloid leukemia, suggesting a new standard of care approach.
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