Cardiology
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A Mobility-Enabled Active Driver for Berlin Heart EXCOR Showed Zero Major Device Malfunctions in High-Risk Pediatric VAD Support
In a prospective multicenter study, the EXCOR Active Driver demonstrated excellent reliability and high short-term survival in children requiring ventricular assist support, while supporting a registry-enabled pathway for class III pediatri
Risk-Based Nurse-Managed Personalized Heart Failure Interventions: The ALLEVIATE-HF Trial
The ALLEVIATE-HF trial found that implantable monitor-based risk alerts with nurse-managed diuretic treatment were safe but did not significantly improve the main heart failure outcome composite.
Arrhythmia Burden and Clinical Responses Under Continuous Monitoring in Heart Failure: Findings from the ALLEVIATE-HF Trial
Continuous implantable monitoring in heart failure revealed a high burden of arrhythmias, strongly linked to hospitalizations and treatment changes, but not reduced by protocol-directed congestion management.
The Prognostic Value of Serum Interleukin-6 Concentrations for 9 Cardiovascular and Mortality Outcomes
Higher blood IL-6 levels were strongly linked to nine cardiovascular and mortality outcomes in nearly 60,000 adults, supporting IL-6 as an important inflammatory marker and potential prevention target.
Lifestyle-Induced Visceral Fat Loss as a Key Target for Durable Cardiometabolic Health: MRI-Based 5- and 10-Year Follow-Up After Two Clinical Trials
Long-term follow-up after two lifestyle trials found that reductions in visceral fat, more than overall weight loss, were linked to sustained cardiometabolic benefits and a lower risk of type 2 diabetes.
Food Delivery After Heart Failure Hospitalization Was Feasible but Did Not Reduce 90-Day HF Readmissions
A randomized trial found that medically tailored meals and fresh produce were highly feasible after HF hospitalization, but neither strategy improved the primary 90-day heart failure utilization outcome versus usual care.
Macrophage circHIPK2 Silencing Reduces Post-Infarction Inflammation and Fibrosis and Improves Cardiac Recovery
A 2026 European Heart Journal study identifies macrophage circHIPK2 as a regulator of post-MI inflammation and fibrosis, with macrophage-targeted silencing improving cardiac remodeling in mice and showing translational promise in human myoc
Tirzepatide Produced Broad 72-Week Improvements in Cardiovascular Risk Biomarkers Across Inflammatory, Metabolic, Endothelial, and Thrombotic Pathways in Obesity
In a SURMOUNT-1 post hoc analysis, tirzepatide improved multiple cardiovascular risk biomarkers over 72 weeks in obesity, with the largest and most consistent effects seen for inflammation, insulin resistance, adiposity-related markers, end
Higher Resting Heart Rate Still Signals Risk After Myocardial Infarction, and Stopping β-Blockers Raises Heart Rate Without Identifying a Safe Subgroup
A secondary analysis of ABYSS shows that in stable post-MI patients with preserved ejection fraction, higher heart rate remains prognostic and β-blocker interruption increases heart rate by about 10–13 bpm while worsening outcomes across he
Role of Atrial Pacing Support in Cardiac Resynchronization Therapy: A Noninferiority Randomized Trial
A randomized trial found that a two-lead CRT-D system without atrial pacing was noninferior to standard three-lead CRT-D in selected heart failure patients, with fewer atrial lead-related complications.
A Genome-First Study of Familial Hypercholesterolemia in African and European Ancestry Individuals
A genome-first study found similar rates of pathogenic FH variants in African and European ancestry groups, but uncertain variants were more common and potentially more harmful in African ancestry individuals, highlighting the need for more
Olfactory Receptor Signaling as a Novel Antiplatelet Strategy: OR2L13 Activation, HSP27 Phosphorylation, and Cytoskeletal Control of Arterial Thrombosis
A 2026 Circulation study identifies OR2L13 agonism as a first-in-class platelet inhibitory strategy that suppresses aggregation and arterial thrombosis through HSP27-dependent actin remodeling without an apparent hemostatic penalty in precl
WNT5a Signaling Disruption Drives Cardiac Pathogenesis in LMNA-Related Emery-Dreifuss Muscular Dystrophy
Aberrant WNT5a-mediated actin filament dynamics underlie cardiac dysfunction and arrhythmias in LMNA-related Emery-Dreifuss Muscular Dystrophy, revealing novel therapeutic targets via RhoA activation and actin stabilization.
Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study
ORBITA-FIRE shows that angina occurs at much lower, individualized FFR and RFR thresholds than standard ischemia cutoffs, and these thresholds rise with exercise intensity.
Cardiac Sarcoidosis May Be Driven by a Heart-Resident Autoimmune B-Cell Axis Linked to Periplakin
Single-cell and spatial transcriptomics suggest that cardiac sarcoidosis evolves through region-specific inflammatory programs and intracardiac B-cell autoimmunity, with periplakin emerging as a candidate autoantigen.
Cold Weather Triggers Acute Heart Failure Decompensation, but Hemodynamic Phenotypes Show Opposite Temperature Risks
A large Tokyo case-crossover study found that short-term exposure to low ambient temperature increases acute heart failure admissions, especially in older adults, while patients with hypotensive presentations may be more vulnerable to heat.
Precision Prescribing of SGLT2 Inhibitors in Type 2 Diabetes for Primary Prevention of Heart Failure
A validation study developed SABRE, a model that estimates how much SGLT2 inhibitors can reduce heart failure risk in people with type 2 diabetes, helping clinicians target preventive treatment more precisely.
Precision Prescribing of SGLT2 Inhibitors in People With Type 2 Diabetes for Primary Prevention of Heart Failure: Model Development and Validation Study
The SABRE model estimates which people with type 2 diabetes may benefit most from SGLT2 inhibitors to prevent heart failure before it develops.
Sex-Based Patterns and Trends in Transcatheter Aortic Valve Implantation
A nationwide Medicare study found that women made up a declining share of TAVI patients, had more periprocedural complications, but slightly better long-term survival than men. The findings support sex-specific planning and follow-up in aor
Great Debate: Is the New Risk Factor-Weighted Clinical Likelihood Model Useful for Estimating Pre-Test Probability of Obstructive Coronary Artery Disease?
The RF-CL model is a new ESC-recommended tool for estimating the pre-test probability of obstructive CAD in suspected chronic coronary syndromes. It improves risk stratification and may reduce unnecessary testing, though symptom interpretat
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