Cardiology
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Rethinking Magnesium Prophylaxis for Postoperative Atrial Fibrillation in Cardiac Surgery: A Synthesis of Clinical Evidence
Recent high-quality randomized clinical trials and meta-analyses suggest that routine magnesium sulfate infusion does not effectively prevent postoperative atrial fibrillation in cardiac surgery, especially when used alongside standard beta
Extracorporeal Cardiopulmonary Resuscitation for Pediatric Out-of-Hospital Cardiac Arrest
In selected children with out-of-hospital cardiac arrest, extracorporeal CPR was associated with higher one-month survival and better neurologic outcomes than continued conventional CPR, though the study was observational and estimates were
Pulmonary Artery Pressure Falls After ARNI and MRA Initiation, but Not SGLT2 Inhibitors, in Hemodynamically Monitored Heart Failure: Insights From GUIDE-HF
In a GUIDE-HF analysis using CardioMEMS, new ARNI and MRA initiation was associated with modest short-term reductions in diastolic pulmonary artery pressure, whereas SGLT2 inhibitor initiation showed no detectable pressure change and β-bloc
Premature Natural Menopause Signals Higher Lifetime Coronary Heart Disease Risk in Both Black and White Women
A pooled US cohort analysis found that natural menopause before age 40 was associated with about a 40% higher lifetime risk of coronary heart disease in both Black and White women, supporting its use as a routine cardiovascular risk-enhanci
Higher Hospital Myectomy Volume Was Linked to Fewer Early Complications in Dutch Hypertrophic Obstructive Cardiomyopathy Surgery
In a 12-hospital Dutch registry, surgical myectomy effectively relieved LVOT obstruction, but 30-day complications were more frequent in low-volume centers, in women, and when at least two concomitant procedures were performed.
Higher Interleukin-6 Levels Predict Broad Cardiovascular Risk and Mortality Across Diverse Cohorts
A pooled analysis of 59,396 participants found that higher serum IL-6 concentrations independently predicted nine cardiovascular and mortality outcomes, with consistent associations across key clinical subgroups.
Genome-First Data Suggest Familial Hypercholesterolemia Is Equally Prevalent Across African and European Ancestry Groups, but Underclassified in African Ancestry Patients
A large multi-cohort genome-first study found similar prevalence of pathogenic FH variants across ancestries, but more VUSs and greater LDL-C and myocardial infarction risk among African ancestry individuals, highlighting likely underclassi
Liberal Transfusion Still Appears Favored in Myocardial Infarction With Anemia, Regardless of Critical Illness Status
A MINT trial subanalysis found no evidence that ICU status changes the relative effect of restrictive versus liberal transfusion in acute myocardial infarction with anemia.
Younger Adults With Type 2 Diabetes Show a More Adverse Cardiometabolic Profile Than Older Adults
Across four national cohorts, younger adults with type 2 diabetes had higher adiposity and triglycerides, while glycemia peaked in midlife and blood pressure and albuminuria rose with age, suggesting age-specific pathways to diabetes compli
Routine Surgical Left Atrial Appendage Occlusion Did Not Improve 1-Year Outcomes in Valvular Surgery Patients Without Atrial Fibrillation: Insights From the OPINION Trial
In OPINION, prophylactic left atrial appendage occlusion during valve surgery did not significantly lower stroke, TIA, or cardiovascular death at 1 year in patients without pre-operative atrial fibrillation.
Implantable Monitor–Guided, Nurse-Led Diuretic Escalation Was Safe but Did Not Improve Outcomes in ALLEVIATE-HF
In ALLEVIATE-HF, ICM-based high-risk detection linked to centralized nurse-managed diuretic intervention was safe, but did not significantly improve the hierarchical composite outcome versus observation.
Circulating MicroRNA Scores May Distinguish Cellular and Antibody-Mediated Heart Transplant Rejection With High Accuracy
A prospective multicenter study found circulating microRNA rejection scores identified ACR and AMR with strong diagnostic performance and prognostic value, supporting their development as noninvasive tools to reduce reliance on surveillance
Oral Semaglutide and Cardiovascular Risk Factor Changes in High-Risk Type 2 Diabetes
Oral semaglutide improved multiple cardiovascular risk factors in high-risk type 2 diabetes, including HbA1c, weight, systolic blood pressure, inflammation, and some lipid measures, with benefits sustained over nearly four years.
Women with Chronic Coronary Artery Disease: Long-Term Outcomes After PCI vs CABG
In women with chronic severe coronary artery disease, CABG was linked to lower long-term rates of death, stroke, heart attack, repeat revascularization, and cardiovascular readmission than PCI.
Sex- and Age-Specific Genetic Risk Across Dilated and Arrhythmogenic Cardiomyopathy: Insights From the SHaRe Registry
A large registry study found that genetic cardiomyopathy risk varies by sex, age, and gene. TTN truncating variants were more common and earlier in males, while DSP and non-TTN sarcomeric variants were more common in females.
Higher Lipoprotein(a) Marks Greater Coronary Risk Without Prior MI or Stroke, While Evolocumab Delivers Similar Relative Benefit and Larger Absolute Gains
In VESALIUS-CV, elevated baseline Lp(a) independently predicted major coronary events, especially MI, in patients without prior MI or stroke. Evolocumab reduced relative risk similarly across Lp(a) levels, with numerically greater absolute
Frozen Elephant Trunk for Acute Type A Aortic Dissection Delivers Durable 20-Year Outcomes and Fewer Late Aortic Events Than Hemiarch Repair
A 20-year single-center experience suggests frozen elephant trunk plus total arch replacement offers durable survival and fewer late adverse aortic events than hemiarch repair in acute type A aortic dissection.
Vagal Nerve Stimulation in HFrEF Was Safe but Did Not Improve the Primary Composite Outcome in the ANTHEM-HFrEF Trial
In ANTHEM-HFrEF, vagal nerve stimulation in symptomatic HFrEF was feasible and safe, but the underpowered trial did not meet its primary efficacy endpoint after premature sponsor-driven termination.
SREBP1 Activation of NHE3 Weakens Heart Contraction and Worsens Heart Failure
Researchers found that SREBP1 directly activates NHE3 in failing hearts, causing sodium and calcium overload, weaker cardiac contraction, and worse heart failure. The findings reveal a new mechanism in HFrEF and suggest a potential therapeu
Cardiogenic Shock Care Still Varies Widely Across CICUs, Especially in the Choice of Inodilators
A large CCCTN analysis found major institutional and patient-level variation in vasoactive drug selection for cardiogenic shock, highlighting persistent evidence gaps in choosing dobutamine, milrinone, and other vasoactive therapies.
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