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Cardiology

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Cardiology

Unlocking the Variability in Cardiopulmonary Exercise Testing: Impact of Prediction Equations on Exercise Capacity Classification

Different cardiopulmonary exercise testing prediction equations yield widely variable percent-predicted values for peak oxygen uptake, leading to frequent reclassification of exercise performance influenced mainly by body mass index, age, a

Nov 7, 2026
OB/GYN & Women's Health

Decoding Anti-Müllerian Hormone Trajectories During Menopause: Implications for Cardiovascular Health

Analysis of anti-müllerian hormone (AMH) trajectories reveals two distinct decline patterns across menopause, with slower AMH decline linked to higher postmenopausal cardiovascular risk, independent of premenopausal risk factors.

Nov 6, 2026
Cardiology

Integrated Resistance Training, Aerobic Exercise, and Sedentary Behavior Reduction Significantly Lower Cardiovascular Risk in U.S. Women

Consistent resistance training combined with recommended aerobic activity and low sedentary television viewing substantially reduces major cardiovascular events risk in women, particularly myocardial infarction.

Nov 6, 2026
Cardiology

Evaluating Immediate Ambulatory ECG Monitoring for Unexplained Syncope: Insights from the ASPIRED Trial

The ASPIRED trial showed that 14-day ambulatory ECG monitoring after unexplained syncope in the emergency department did not significantly reduce syncope recurrence compared to standard care over one year.

Nov 6, 2026
Cardiology

Enhanced Cardiovascular Risk Prediction Through Combined LDL-C, Lp(a), and hsCRP Assessment in a Multiethnic Population

Combined measurement of LDL-C, lipoprotein(a), and hsCRP improves long-term prediction of atherosclerotic cardiovascular disease in a multiethnic cohort, highlighting important ethnic differences in absolute ASCVD risk.

Nov 5, 2026
Transplantation

Efficacy and Safety of GLP-1 Receptor Agonists in Managing Post-Transplant Diabetes Among Heart Transplant Patients: Insights from a Multicenter Spanish Study

This multicenter retrospective study shows that GLP-1 receptor agonists improve glycemic control and cardiometabolic parameters with good tolerance in heart transplant recipients with type 2 diabetes, supporting their therapeutic role in th

Nov 4, 2026
Cardiology

Anticoagulation in Octogenarians with Atrial Fibrillation: Balancing Mortality Benefits and Bleeding Risks

Anticoagulation therapy in adults aged 80 and older with atrial fibrillation is linked to reduced all-cause mortality despite an increased risk of gastrointestinal bleeding, supporting its continued use in selected elderly patients.

Nov 4, 2026
Cardiology

Impact of Subtypes and Ventriculocoronary Connections on Hypoplastic Left Heart Syndrome Outcomes: Insights from the Fetal Heart Society Multicenter Study

This multicenter study reveals that among HLHS subtypes, mitral stenosis and aortic atresia with ventriculocoronary connections have the poorest transplant-free survival, highlighting the prognostic importance of prenatal and postnatal VCC

Nov 4, 2026
Cardiology

Assessing Cardiovascular Risk Prediction Models in Postmenopausal Women With Chronic Kidney Disease: Insights from the Women’s Health Initiative

Cardiovascular risk prediction models show limited accuracy in postmenopausal women with chronic kidney disease, often underestimating risk, highlighting the need for improved tools in this high-risk population.

Nov 3, 2026
Cardiology

Targeting the Macrophage YTHDC1/TIGAR/NF-κB Axis: A Novel Therapeutic Strategy for Pulmonary Hypertension

This article explores the role of the macrophage YTHDC1/TIGAR/NF-κB axis in pulmonary hypertension and highlights its potential as a therapeutic target to mitigate inflammation-driven vascular remodeling.

Nov 3, 2026
Cardiology

Modulating Coronary Artery Calcification Progression: Insights from the DANCODE Trial on Vitamin K2 and D3 Supplementation

The DANCODE trial demonstrates that combined vitamin K2 and D3 supplementation reduces the progression of severe coronary artery calcification over 24 months without increasing noncalcified plaque burden, offering a promising adjunctive str

Nov 3, 2026
Diabetes & Endocrinology

Metyrapone Treatment in Mild Autonomous Cortisol Secretion: Cardiovascular Benefits and Mechanistic Insights

A 12-week metyrapone regimen lowers blood pressure and reduces epicardial fat in patients with mild autonomous cortisol secretion, suggesting cardiovascular improvements without altering cardiac morphology or function.

Nov 2, 2026
Cardiology

ACADM-Mediated Fatty Acid β-Oxidation in Atherosclerosis and Abdominal Aortic Aneurysm: Distinct Lipid Metabolic Pathways Underlying Vascular Disease

This review elucidates the contrasting roles of ACADM-mediated fatty acid β-oxidation in atherosclerosis and abdominal aortic aneurysm, highlighting differential lipid metabolism and translational implications for diagnosis and therapy.

Nov 2, 2026
Transplantation

Energetic Recovery and Myocardial Efficiency After Heart Transplantation: Insights from an Exploratory Study

This study explores myocardial external efficiency (MEE) and mitochondrial function in heart transplant recipients, revealing improved MEE at 6 months post-transplant associated with myocardial contractility and biomarkers, highlighting ene

Nov 1, 2026
Cardiology

Clinical Implications of Brachial-to-Radial Arterial Pressure Gradients in Critically Ill Patients on Vasoactive Therapy

A significant brachial-to-radial arterial pressure gradient occurs in nearly one-fifth of critically ill patients receiving vasoactive agents, correlating with higher vasoactive doses, greater illness severity, and increased ICU mortality.

Nov 1, 2026
Cardiology

Early Cholesterol-Lowering Therapy in Familial Hypercholesterolaemia: Insights from the SAFEHEART Study

Initiating cholesterol-lowering therapy during childhood in familial hypercholesterolaemia substantially reduces LDL-C burden and cardiovascular risk, highlighting the importance of early diagnosis and treatment.

Nov 1, 2026
Cardiology

SMART-REACH2: A Global Model for Predicting Lifetime Cardiovascular Risk and Tailoring Preventive Therapy in Established Atherosclerotic Disease

The SMART-REACH2 model estimates lifetime recurrent cardiovascular risk and benefits of preventive treatment in patients with established atherosclerotic cardiovascular disease, offering region-specific recalibration and supporting personal

Oct 31, 2026
Cardiology

Micro- and Nano-Plastics in Coronary Circulation: Unveiling Their Role in Ischemic Heart Disease and Air Pollution Exposure

This article evaluates the presence of micro- and nano-plastics in coronary blood of patients with ischemic heart disease, linking their burden to acute coronary events, air pollution exposure, and inflammation, highlighting a novel environ

Oct 30, 2026
Cardiology

Sirolimus-Coated Balloon Angioplasty in Femoropopliteal Artery Disease Without Tissue Loss: Promising Secondary Outcomes from the SirPAD Trial

This secondary analysis of the SirPAD trial shows that sirolimus-coated balloon angioplasty significantly reduces 1-year target-lesion revascularization rates compared to uncoated balloons in femoropopliteal artery disease patients without

Oct 30, 2026
Neurology

Determinants and Outcomes of Vessel Recanalization Following Acute Cervical Artery Dissection: Insights from an International Multicenter Cohort

This multicenter study reveals that nearly 60% of cervical artery dissection patients achieve complete vessel recanalization at 6 months. Older age, diabetes, smoking, and initial complete occlusion markedly reduce recanalization odds, with

Oct 29, 2026
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