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Among type 2 diabetes patients using GLP-1 receptor agonists, oxycodone is linked to higher short-term risks of severe gastrointestinal complications compared to hydrocodone and tramadol, warranting cautious opioid selection in this populat
This article explores genetic heterogeneity in familial thyroid follicular nodular disease, highlighting key gene variants identified via whole-exome sequencing and the implications for diagnosis and management.
This study reveals that diabetes-related genetic risk scores predict pre-transplant diabetes status and influence metabolic outcomes one year after total pancreatectomy with islet autotransplantation in chronic pancreatitis patients.
A large retrospective cohort study suggests that cetirizine, ibuprofen, and prednisone use in adults with type 2 diabetes is associated with significantly reduced incidence of diabetic macular edema and proliferative diabetic retinopathy, h
This article reviews expert perspectives on the efficacy and safety of SGLT inhibitors for cardiovascular and renal disease in type 1 diabetes, outlines translational insights from type 2 diabetes data, and proposes a roadmap for regulatory
Assessment of β-cell dysfunction using stimulated glucose and C-peptide measures improves risk stratification for type 1 diabetes progression among single autoantibody-positive relatives, enabling personalized monitoring and targeted interv
A nationwide Italian survey reveals significant gaps in endocrinologists’ preparedness for transgender care. Prior education strongly improves knowledge and management skills, highlighting urgent needs for structured training to optim
This article examines the critical need for refined clinical metrics in thyroid eye disease (TED) to better evaluate new targeted therapies, highlighting the Innovate TED Initiative’s efforts to develop and validate comprehensive outcome me
An international expert consensus recommends practical principles and minimum requirements for general‑population screening for islet autoantibodies to detect early-stage type 1 diabetes, reduce DKA, enable early care and access to disease‑
The PROTECT trial’s per-protocol analysis confirms teplizumab’s efficacy in preserving beta cell function, reducing insulin needs, and improving glycemic control in children and adolescents newly diagnosed with stage 3 type 1 di
This study investigates clinical and pharmacological factors influencing serum dexamethasone levels during the 1-mg overnight dexamethasone suppression test, revealing age and BMI as key determinants and highlighting the limited impact of r
A multicenter RCT demonstrates that 10-kHz spinal cord stimulation significantly improves pain relief, sensory function, and nerve fiber density in painful diabetic neuropathy, suggesting potential disease-modifying effects.
Phase 3 trials show satralizumab significantly improves proptosis, inflammation, and diplopia in thyroid eye disease with a favorable safety profile, marking a new therapeutic option targeting the IL-6 receptor pathway.
This review examines the role of FreeStyle Libre Pro iQ CGM in differentiating presymptomatic stages of type 1 diabetes and predicting progression to clinical disease, comparing its performance with Dexcom G6 and discussing implications for
This article explores the unique challenges autistic transgender and gender diverse adults face in adhering to gender-affirming hormone therapy (GAHT) and highlights strategies to support effective therapy adherence in clinical endocrinolog
This study reveals that individuals with Congenital Adrenal Hyperplasia (CAH) experience early, frequent, and complex hospitalizations with higher risk of severe outcomes, especially in infancy, compared to non-CAH patients, emphasizing the
This cohort study links polygenic scores for macronutrient intake with specific food choices in children and adolescents, highlighting genetic pathways involving hypothalamic appetite regulation but limited effects on cardiometabolic outcom
A study reveals a significant secular increase in islet autoimmunity incidence among Colorado children from 1993 to 2010, particularly in those with moderate-risk HLA genotypes, highlighting evolving risk profiles beyond known environmental
A significant proportion of real-world diabetic macular edema patients are excluded from clinical trials of anti-VEGF therapy due to stringent systemic criteria, disproportionately affecting racial minorities. This study highlights the need
This 12-month analysis in adults with type 1 diabetes using advanced diabetes technology reveals that fear and perceived hypoglycemia frequency do not straightforwardly relate to continuous glucose monitoring metrics, highlighting complex d
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