Diabetes & Endocrinology
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Biochemical Control Is Not Enough: Why Acromegaly Still Carries Major Quality-of-Life and Treatment Burden
A 2026 review shows that many patients with acromegaly remain symptomatic and functionally impaired despite biochemical control, underscoring the need for routine patient-reported outcomes and lower-burden, multidisciplinary care.
Early 15% Weight Loss After Type 2 Diabetes Diagnosis Linked to Lower Complication Risk
In a large U.K. cohort, losing at least 15% of body weight within 2 years of type 2 diabetes diagnosis was linked to lower risks of heart, kidney, and eye complications, along with better glucose and blood pressure control.
Poor Glycemic Control and Higher Blood Pressure Track With Early Diabetic Retinal Disease in Youth With Type 1 Diabetes
A large retrospective study links higher HbA1c and elevated blood pressure to diabetic retinopathy in youth with type 1 diabetes, while worse glycemia also correlates with thinner inner retinal layers suggestive of early neurodegeneration.
Prevalence and Clinical Characteristics of Macro-TSH in Patients with Subclinical Hypothyroidism
Macro-TSH was rare but clinically important in patients with subclinical hypothyroidism, sometimes mimicking true thyroid disease and leading to unnecessary levothyroxine use. Specialized testing confirmed multiple immunoglobulin-linked TSH
Swedish Population Data Suggest SARS-CoV-2 Infection and COVID-19 Vaccination Do Not Confer a Sustained Causal Risk of New-Onset Type 1 Diabetes
In a nationwide Swedish cohort, type 1 diabetes diagnoses rose briefly after SARS-CoV-2 infection and first vaccine dose, but the signal was short-lived, supporting diagnostic acceleration rather than a durable causal effect.
Pituitary Adenoma Imaging as a Key Determinant of Acromegaly Diagnosis and Outcomes
High-quality pituitary imaging is essential for diagnosing and managing acromegaly, localizing somatotroph adenomas, guiding surgery or radiotherapy, and reducing treatment-related harm. A standardized, tiered MRI-based approach improves ac
Waist-to-Height Ratio Is Linked to Coronary Artery Disease Risk in Type 1 Diabetes: 19-Year Study
A 19-year Finnish cohort study found that a higher waist-to-height ratio was linked to increased coronary artery disease risk in type 1 diabetes, especially in people without albuminuria.
Diabetes Markedly Raises Sudden Cardiac Death Risk, With the Greatest Excess Hazard in Younger Adults
A Danish nationwide study found substantially higher sudden cardiac death rates in both type 1 and type 2 diabetes, especially at younger ages, with meaningful loss of life expectancy attributable to sudden cardiac death.
Diabetes and Sudden Cardiac Death: Findings from a Danish Nationwide Study
A nationwide Danish study found that type 1 and type 2 diabetes substantially increase sudden cardiac death risk, especially in younger adults, and contribute meaningfully to shortened life expectancy.
Veligrotug Delivers Rapid, Durable Benefit in Active Thyroid Eye Disease in the Phase 3 THRIVE Trial
In phase 3 testing, veligrotug produced rapid and clinically meaningful reductions in proptosis, diplopia, and disease activity in active thyroid eye disease, with durable benefit through 52 weeks and a favorable short-term safety profile.
Phase 2 Study of XP-8121: Once-Weekly Subcutaneous Levothyroxine for Adult Hypothyroidism
A Phase 2 trial found that once-weekly subcutaneous levothyroxine (XP-8121) was generally well tolerated and suggested a dose conversion of about four times the daily oral dose for adults with hypothyroidism.
Early HbA1c Control After Type 2 Diabetes Diagnosis May Shape Long-Term Cancer Risk
In a large Hong Kong cohort with newly diagnosed type 2 diabetes, higher early HbA1c exposure was associated with greater long-term cancer risk, suggesting that glycaemic control soon after diagnosis may matter more than later improvement.
Food Coloring Additives Linked to Higher Type 2 Diabetes Risk in a Large French Cohort
A large French cohort study found that higher exposure to several food coloring additives was associated with increased incidence of type 2 diabetes, highlighting the need for further research and possible reevaluation of some additives.
No Signal for Increased Neovascular AMD Risk With Semaglutide in Adults With Type 2 Diabetes: Interpretation of a Large OHDSI Network Study
A multinational OHDSI network analysis found no meaningful association between semaglutide use and neovascular age-related macular degeneration among adults with type 2 diabetes across cohort and self-controlled designs.
Long-Term Risk of Hypothyroidism After Thyroid Abnormalities Identified in Pregnancy
Thyroid abnormalities found during pregnancy, especially when subclinical hypothyroidism and TPO antibodies coexist, can signal a much higher long-term risk of overt hypothyroidism, supporting ongoing thyroid follow-up after delivery.
Detectable Antithyroglobulin Antibodies Above the Assay LOQ Signal Higher Recurrence Risk in Papillary Thyroid Carcinoma Despite Undetectable Thyroglobulin
In papillary thyroid carcinoma treated with thyroidectomy and RAI, TgAb levels above the assay’s limit of quantification identified patients with higher long-term recurrence risk despite undetectable serum thyroglobulin.
Beta Cell Glucose Sensitivity May Predict Response to New-Onset Type 1 Diabetes Therapies
A pooled analysis of nine type 1 diabetes trials found that beta cell glucose sensitivity may better predict response to disease-modifying therapy than C-peptide alone, helping identify patients most likely to benefit.
Genetic Evidence Strengthens High BMI as a Causal Driver of Vascular Dementia, With Blood Pressure as a Partial Mediator
A 2026 Mendelian randomization study supports high BMI as a causal risk factor for vascular-related dementia, with part of the effect mediated through elevated systolic and diastolic blood pressure.
Precision Prescribing of SGLT2 Inhibitors in Type 2 Diabetes for Primary Prevention of Heart Failure
A validated model, SABRE, estimates who with type 2 diabetes may gain the most heart-failure prevention benefit from SGLT2 inhibitors, enabling more precise, individualized prescribing.
Thyroid Dysfunction Is a Cardiovascular Risk Multiplier, but Treatment Benefits Depend on Phenotype, Severity, and Age
Thyroid dysfunction reshapes lipid metabolism, vascular tone, cardiac performance, and rhythm. Cardiovascular risk is clearest at the extremes of thyroid status, while treatment decisions in subclinical disease should remain individualized.
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