Diabetes & Endocrinology
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Tirzepatide Enhances Quality of Life in Adults with Obesity or Overweight: Insights from the SURMOUNT-3 Trial
Tirzepatide significantly improves health-related quality of life alongside weight reduction in adults with obesity or overweight, especially those experiencing physical function limitations, according to SURMOUNT-3 trial results.
Tirzepatide Significantly Lowers Predicted 10-Year Type 2 Diabetes Risk in Chinese Adults with Overweight or Obesity: Insights from the SURMOUNT-CN Trial
Post hoc analysis of the SURMOUNT-CN trial shows tirzepatide markedly reduces the 10-year predicted risk of type 2 diabetes in Chinese individuals with overweight or obesity, regardless of baseline BMI or prediabetes status.
Flexovital Food Supplement Shows Promise in Mitigating Cardiovascular-Kidney-Metabolic Syndrome in Preclinical Model
Flexovital, a nitric oxide-enhancing supplement, effectively attenuates metabolic, cardiovascular, and renal dysfunctions in a mouse model of cardiovascular-kidney-metabolic syndrome induced by unilateral nephrectomy and Western diet.
CagriSema: A Breakthrough Combination Therapy for Weight Loss in Adults with Overweight or Obesity
A phase 3a trial shows coadministered cagrilintide and semaglutide (CagriSema) significantly reduce body weight up to 20.4% over 68 weeks in adults with overweight or obesity, with manageable side effects, offering a promising new option fo
Efruxifermin Demonstrates Promising 96-Week Efficacy and Safety in Treating Metabolic Dysfunction-Associated Steatohepatitis: Insights from the Phase 2b HARMONY Trial
The HARMONY trial reveals that once-weekly efruxifermin significantly improves liver fibrosis without worsening MASH over 96 weeks, with a favorable safety profile supporting its phase 3 evaluation.
ION224: A Promising Antisense Oligonucleotide Therapy for Metabolic Dysfunction-Associated Steatohepatitis (MASH)
The phase 2 ION224-CS2 trial demonstrates that ION224, a DGAT2 antisense oligonucleotide, safely improves liver histology in MASH patients independent of weight loss, offering a potential new therapeutic approach.
Efficacy and Safety of Ecnoglutide, a cAMP-Biased GLP-1 Receptor Agonist, in Weight Management for Overweight and Obese Adults: Insights from a Phase 3 Multicentre Randomised Trial
This review synthesizes evidence from a multicentre, phase 3 trial on ecnoglutide, demonstrating significant and sustained weight loss in overweight/obese adults without diabetes, with a favorable safety profile, supporting its clinical use
Don’t Let High Uric Acid Target Your Child: Recognizing Symptoms and Avoiding Risky Habits
Childhood high uric acid is rising alarmingly. Learn the causes, warning signs, and effective prevention strategies to protect your child’s lifelong health.
Metabolic Syndrome: The Hidden Highway to Dementia in Older Adults
Metabolic syndrome—characterized by five key metabolic risk factors—significantly increases the risk of dementia, especially vascular dementia, among older adults. Early detection and lifestyle interventions are crucial to protect brain hea
Improving Sleep Quality through Cognitive Behavioural Therapy Alters Food Preferences in Adults with Overweight and Obesity
Cognitive behavioural therapy for insomnia enhances self-reported sleep quality and duration, reduces cravings for sweet and savoury foods, and shifts implicit food preferences in adults with overweight or obesity, though dietary intake cha
Intermittent Fasting vs Low-Calorie Diet in Managing Metabolic-Associated Fatty Liver Disease: Comparative Effects on Inflammation, Lipids, Glycemic Control, and Liver Fibrosis
This RCT compares 16:8 intermittent fasting and low-calorie diets in MAFLD patients, revealing both improve liver enzymes and anthropometrics, but low-calorie diet shows superior reduction in liver steatosis, fibrosis, and triglycerides.
Association of Testosterone-Induced Neutrophil and Monocyte Elevation with Thromboembolic Risk: Insights from the TRAVERSE Trial
The TRAVERSE trial reveals that testosterone replacement therapy elevates neutrophil and monocyte counts in hypogonadal men, correlating with increased venous thromboembolism and cardiovascular event risk, underscoring the need to monitor t
Thyroid Hormone Levels as Predictors of Long-Term Outcomes in Chronic Critical Illness
Low FT3 and FT4 levels in chronic critical illness correlate with increased 90-day mortality, supporting thyroid function as a valuable prognostic marker and guide for early clinical intervention.
Gene-Environment Interplay in Hyperinsulinemia and Serum Urate Regulation via SLC22A12: Implications for Personalized Hyperuricemia Management
This article elucidates how gene-environment interactions involving SLC22A12 and hyperinsulinemia regulate serum urate, providing mechanistic insights and identifying potential for personalized hyperuricemia therapies.
Epaminurad: A Promising hURAT1 Inhibitor for Effective and Safe Gout Management – Insights from a Phase 2b Dose-Finding Trial
Epaminurad significantly lowers serum urate levels in gout patients with excellent safety, offering a promising alternative to existing therapies. This randomized controlled trial identifies optimal dosing and confirms tolerability over 12
Time-of-Day Effects of Green Tea Extract on Postprandial Glycemia and Insulinemia in Healthy Adults: Insights from a Randomized Controlled Cross-Over Trial
Green tea extract reduces morning postprandial insulin peaks but does not alter glucose levels, with notable time-dependent effects linked to circadian rhythms influencing insulin sensitivity in healthy adults.
Fruit Juice or Whole Fruit for Breakfast in Type 2 Diabetes? Understanding Blood Sugar Control Challenges
A recent randomized trial shows that consuming 100% orange juice, whole orange pieces, or a sugar-sweetened beverage with breakfast results in similar acute postprandial glycemic responses in well-controlled type 2 diabetes patients.
Recent Advances in Cinnamon and Its Extracts: Clinical Applications and Therapeutic Potentials Across Metabolic, Cardiovascular, Cognitive, and Infectious Diseases
A decade of research highlights cinnamon’s benefits in glycemic control, lipid modulation, anti-inflammatory effects, cognitive enhancement, and antimicrobial activity, supporting its adjunctive clinical use and revealing promising therapeu
Sulforaphane in Clinical Medicine: A Decade of Research Progress and Therapeutic Potential
This review synthesizes 10 years of sulforaphane (SFN) research, highlighting its pharmacology, clinical trial outcomes, and emerging therapeutic prospects across cancer, metabolic, renal, neurodevelopmental, and cardiovascular disorders.
Recent Advances in Dihydroberberine Research: Pharmacokinetics, Mechanisms, and Clinical Potential
This review synthesizes the latest 5-year evidence on dihydroberberine, highlighting improved bioavailability over berberine, mechanistic insights from metabolic and network pharmacology studies, and its promising clinical applications in m
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