Section
The ENDIA study reveals early alterations in exocrine pancreatic biomarkers, fecal elastase-1 and serum immunoreactive trypsin, in children predisposed to type 1 diabetes, suggesting novel early disease pathogenesis markers.
Long-term treatment with vutrisiran provides sustained improvements in mortality, cardiovascular events, cardiac biomarkers, functional capacity, and quality of life in patients with transthyretin amyloidosis cardiomyopathy, emphasizing the
Athletes with ACL reconstruction show persistent neurocognitive deficits during decision-making under uncertainty, marked by altered cortical oscillatory dynamics that may increase reinjury risk, highlighting the need for neurocognitive ass
This study evaluates the feasibility and safety of a real-time ultrasound-assisted laryngeal electromyography technique using a single in-plane trajectory view, showing 100% muscle sampling success and minimal adverse events in elderly pati
This article reviews a novel injectable peptide nanofiber gel that significantly improves bone-implant integration and biomechanical stability in a rabbit model, offering a promising approach to overcome limitations of traditional implant c
TAVR significantly reduces death and heart failure events compared to clinical surveillance in patients with moderate aortic stenosis exhibiting at-risk features, marking a potential new therapeutic approach.
Bariatric surgery offers substantial 2-year weight loss for patients with obesity who experience intolerable side effects or inadequate response to semaglutide or tirzepatide, with Roux-en-Y gastric bypass demonstrating superior outcomes in
High-intensity locomotor training in chronic stroke patients induces significant strengthening and lateralization of the contralesional cortico-reticulospinal tract, correlating with improved walking capacity, elucidating new neuroplastic m
A comparative study shows clinicians outperform AI in fixed-threshold periodontal prognosis, but AI matches clinician accuracy using optimal thresholds, highlighting AI’s potential alongside experts in predicting long-term tooth loss.
The MIRA2 trial demonstrates that adding a levonorgestrel-releasing intrauterine system immediately after endometrial ablation significantly reduces hysterectomy rates in women with heavy menstrual bleeding, without increasing serious adver
This article reviews a pediatric emergency department initiative that increased optimal antibiotic prescribing for community-acquired pneumonia and acute bacterial rhinosinusitis, improving adherence to updated short-course guidelines and m
A study of 14,362 Nordic PsA patients reveals 2% have difficult-to-manage disease and 1.2% are treatment-refractory on b/tsDMARDs, highlighting clinical challenges and associations with female sex, depression, and opioid use.
This study evaluates the shift from restrictive cardiopulmonary bypass (CPB) to criteria-based extracorporeal membrane oxygenation (ECMO) in lung transplantation, revealing a reduction in early major neurologic complications and ischemic st
Dupilumab treatment in children aged 6–11 with severe atopic dermatitis is associated with significant improvements in linear growth and bone biomarker levels over one year, suggesting benefits beyond skin clearance.
This article reviews a prospective study identifying subcutaneous adipose tissue (SAT) and smoking history, not BMI or physical fitness, as superior predictors of postoperative complications in DIEP flap breast reconstruction, enhancing ris
Abdominal solid organ transplant recipients with sepsis show improved survival linked to distinctive immune and metabolic signatures, including attenuated inflammation and preserved innate immunity, providing novel insights for clinical man
This review synthesizes recent evidence demonstrating that both human and ambient AI scribes reduce emergency physician documentation time without diminishing clinical productivity, highlighting evolving technology adoption and future resea
A Johns Hopkins study found that a comprehensive Chronic Care Management program significantly reduced hospitalizations, emergency visits, and acute care costs among high-risk patients, demonstrating the value of coordinated multidisciplina
This article delineates the pivotal role of CD4+ T cells in mediating immune responses against ALK-positive anaplastic large cell lymphoma, highlighting preclinical evidence supporting immune checkpoint inhibitors as a promising therapeutic
Spatial proteomics reveals how EGFR and KRAS mutations distinctly remodel the immune microenvironment in non-small cell lung cancer, identifying immune niches and prognostic markers that may guide immunotherapy strategies.
