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This review synthesizes claims-based evidence revealing $106.7 billion US injury spending in 2022, highlighting mechanistic, demographic, and payer-specific spending patterns with implications for trauma system design and health policy.
This review synthesizes current evidence on adalimumab, secukinumab, and bimekizumab for moderate-to-severe hidradenitis suppurativa, emphasizing clinical efficacy, safety, mechanistic insights, and cost-effectiveness across diverse health
This review synthesizes evidence on physician-focused financial incentives for hypertension control, highlighting nuanced impacts on clinical decisions, documented blood pressure control, and cardiovascular outcomes, with a focus on both ov
Antenatal magnesium sulfate (MgSO4) use before very preterm birth significantly improves survival free of cerebral palsy and moderate-severe impairment, with evidence from randomized trials and large cohort data supporting enhanced neuropro
Patients with opioid use disorder (OUD) face higher postoperative complications, longer inpatient stays, and increased costs following hysterectomy. This review synthesizes clinical evidence and explores implications for surgical management
This review synthesizes evidence on statin therapy reducing hepatic decompensation and major adverse liver outcomes in primary biliary cholangitis, highlighting a recent robust target trial emulation study across diverse populations.
End-stage metabolic dysfunction-associated steatohepatitis (MASH) features profound disruptions in thyroid hormone metabolism across liver, portal, and systemic compartments, with the hepatic T3 level and systemic T3/rT3 ratio serving as se
This review synthesizes evidence from the STEP 12 trial and related studies demonstrating that once-weekly semaglutide 2.4 mg significantly reduces bodyweight and improves cardiometabolic outcomes in Chinese adults with overweight or obesit
Elevated endogenous insulin and insulin resistance independently predict progression of diastolic dysfunction and increased cardiovascular mortality, highlighting early metabolic dysregulation as a target to prevent heart failure with prese
This review synthesizes recent evidence on adult subvalvular aortic stenosis, highlighting long-term clinical outcomes, disease progression, and implications for management and follow-up strategy.
This review synthesizes evidence on the adoption and billing practices of telemedicine critical care for Medicare beneficiaries from 2018 to 2024, highlighting pandemic-driven shifts, provider and hospital characteristics influencing utiliz
A multimodal human factors program enhances team communication, nontechnical skills, and workflow during pediatric airway endoscopy, supporting OR culture change despite unchanged immediate clinical outcomes.
This review synthesizes contemporary evidence on the survival impact of adding defibrillators to CRT in nonischemic cardiomyopathy, highlighting heterogeneous results including the DECIDE-CRT study and underscoring the need for personalized
This review synthesizes clinical trial evidence supporting digital patient-reported outcome monitoring with alert-based interventions to reduce fatigue and improve physical functioning in metastatic breast cancer.
This review analyzes the increased incidence of migraine and sinus headaches in primary rhinoplasty patients, emphasizing the clinical significance of screening rhinogenic headache triggers during septorhinoplasty to enhance both symptomati
This review synthesizes evidence on individual and institutional factors linked to suspected suicide among higher-education students in England, highlighting risk profiles, service contact patterns, and shortcomings in investigation practic
This review synthesizes recent evidence on the effectiveness of 2024-2025 COVID-19 vaccines in adults, highlighting moderate protection against symptomatic illness, hospitalization, and critical outcomes, with emphasis on waning immunity an
Inflammatory blood biomarkers consistently predict long-term recurrent stroke risk up to 10 years post-event, independent of traditional vascular risk factors, underscoring the potential for anti-inflammatory secondary prevention strategies
This review explores the role of dysregulated iron metabolism and inflammation, particularly elevated serum ferritin, in isolated REM sleep behavior disorder (iRBD) as a prodromal stage of neurodegeneration, synthesizing recent longitudinal
Automated speech analysis of brief connected speech accurately identifies clinical, anatomical, and neuropathological variants of primary progressive aphasia, facilitating scalable diagnosis and monitoring.
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