Section
Report of adult-onset retinitis pigmentosa linked to bi-allelic loss-of-function PRKCZ variants, highlighting clinical features, genetic diagnosis, and validation of pathogenic mechanisms.
This article reviews the clinical presentation, diagnostic challenges, and management strategies for cavernous sinus thrombosis (CST), emphasizing early diagnosis, imaging findings, and the critical role of sinus surgery and anticoagulation
This study evaluates different machine preservation strategies in donation after circulatory death (DCD) liver transplantation, highlighting their impact on graft outcomes, particularly nonanastomotic biliary strictures and survival rates,
This review synthesizes evidence from randomized trials indicating that baseline lipid profiles significantly modify coronary heart disease risk associated with oral menopausal hormone therapy, underscoring the importance of lipid assessmen
B-BEST, a novel single-cell RNA sequencing technique, reveals heterogeneity in HBV-infected hepatocytes, linking viral replication states to host cellular pathways, inflammation, and antiviral responses, with implications for precision HBV
This review highlights disparities in epilepsy etiology and severity between Māori and non-Māori-non-Pasifika children in New Zealand, emphasizing socioeconomic and rurality factors driving preventable epilepsy in Māori youth.
A prospective cohort study identifies three clinical and metabolic subtypes of recent-onset adult type 1 diabetes, revealing distinct disease dynamics, β-cell function trajectories, and complication risks that can guide personalized interve
This Phase 1b trial demonstrates that oral NLRP3 inhibition with ruvonoflast markedly reduces systemic inflammatory biomarkers in obese individuals at elevated cardiovascular risk, with favorable safety and tolerability, supporting further
This study cross-validates resting metabolic rate (RMR) prediction equations in Division I and III collegiate male wrestlers, developing new equations with improved accuracy to guide nutritional and training strategies.
Despite reasonable understanding of concussion mechanisms, Australians demonstrate significant gaps in knowledge about recovery following traumatic brain injury, underscoring the need for targeted education to improve rehabilitation engagem
The RETURN trial demonstrated that a nurse-led behavioral intervention modestly increased planned dental visits and reduced dental anxiety among adults attending urgent dental care, particularly benefiting socioeconomically disadvantaged gr
A pivotal phase 3 trial demonstrates improved event-free and overall survival with perioperative durvalumab combined with neoadjuvant enfortumab vedotin, with or without tremelimumab, versus surgery alone in muscle-invasive bladder cancer p
This RCT demonstrates that chitosan sponges, especially when enriched with injectable platelet-rich fibrin, significantly improve palatal wound healing and patient comfort following free gingival graft harvesting compared to gelatine sponge
The PROSpect trial found no improvement in ventilator-free days with prone positioning or HFOV compared to conventional ventilation in children with moderate-to-severe PARDS, cautioning against their routine first-line use due to safety con
This study reveals that a parenting intervention improved child cognitive and language development primarily when caregivers exhibited no baseline mental health symptoms, highlighting the moderating role of caregiver mental health in early
A novel triage approach combining telephone screening and brief rheumatologist consultation effectively prioritizes patients with inflammatory rheumatic diseases, shortening wait times and improving resource allocation while underscoring th
In hospitalized patients with cirrhosis awaiting liver transplant, the AM-PAC “6-Clicks” Basic Mobility Score correlates strongly with both pretransplant waitlist mortality and posttransplant survival, offering a practical risk
This study demonstrates that physiological concentration platelet fibrin plasma (PFP) is noninferior to supraphysiological platelet-rich plasma (PRP) in healing neuro-ischemic diabetic foot ulcers and other diabetic wounds, offering a simpl
This article reviews a novel pedicled lymphatic system transfer using the superficial circumflex iliac perforator flap to effectively treat lower extremity lymphedema complicated by chronic venous disease, demonstrating promising functional
This RCT explored music therapy’s role during invasive mechanical ventilation weaning in ICU patients, showing benefits in agitation reduction, sedation needs, and tracheostomy rates, though weaning duration was unaffected.
