Clinical Updates
Latest news
1025 articles · 20 / page
Optimizing Anabolic Therapy: A Comparative Analysis of 3-Month vs. 12-Month Romosozumab Regimens in Postmenopausal Osteoporosis
This review analyzes the LIDA trial findings, demonstrating that an abbreviated 3-month romosozumab course followed by denosumab is non-inferior to the standard 12-month regimen in increasing total hip bone mineral density, potentially redu
Abbreviated Romosozumab Regimens in Postmenopausal Osteoporosis: A Review of the LIDA Trial and the Shift Toward Precision Anabolic Dosing
This review evaluates the LIDA trial’s findings that 3 months of romosozumab followed by denosumab is non-inferior to 12 months of romosozumab, offering a cost-effective strategy to mitigate long-term side effects.
Precision Rehabilitation for Chronic Stroke: Validating Targeted Ipsilesional Arm Training to Enhance Functional Capacity
A pivotal randomized clinical trial reveals that targeted training of the ipsilesional arm in chronic stroke patients with severe hemiparesis significantly improves motor speed and hand function, with benefits sustained for six months.
Management of Graves’ Disease During Pregnancy: Clinical Insights from the Danish PRETHYR Multicenter Study
This clinical review synthesizes findings from the PRETHYR study on antithyroid drug use in pregnant women, highlighting treatment transitions, biochemical predictors, and the impact of specialist-led management in Denmark.
Transitioning to Tubeless Automated Insulin Delivery: Clinical Insights from the RADIANT Trial and Contemporary Management of Type 1 Diabetes
This review synthesizes the landmark RADIANT trial findings, demonstrating the efficacy of transitioning patients from multiple daily injections to tubeless automated insulin delivery, while integrating broader evidence on genetic susceptib
Precision Prediction of Incident Heart Failure: The Clinical Integration of AI-Enabled Electrocardiography
This review evaluates the breakthrough ECG2HF model, a publicly available AI tool that outperforms standard clinical scores in predicting 10-year heart failure risk using 12-lead ECG waveforms.
Genotype-Phenotype Divergence in Hypertrophic Cardiomyopathy: Deciphering the Trajectories of Sarcomeric and Nonsarcomeric Disease
This review analyzes the SHaRe registry data, revealing that sarcomeric HCM represents a more aggressive clinical phenotype with earlier onset and higher HCM-related mortality compared to nonsarcomeric cases, which are more heavily influenc
Potent Inhibition of Hepatitis E Virus Replication by Bemnifosbuvir: Preclinical Evidence and Clinical Prospects
Preclinical studies demonstrate that the nucleotide analogue bemnifosbuvir effectively suppresses Hepatitis E virus (HEV) replication, showing synergistic potential with ribavirin and a high genetic barrier to resistance.
Differential Pathophysiological Roles of Centrum Semiovale Perivascular Spaces in Cerebral Amyloid Angiopathy and Deep Perforator Arteriopathy: A Biomarker Synthesis
This review synthesizes evidence distinguishing perivascular space enlargement mechanisms in cerebral amyloid angiopathy (CAA) versus deep perforator arteriopathy (DPA), highlighting the diagnostic utility of CSF Aβ42/40 ratios in vascular
Therapeutic Potential of Autologous Blood Derivatives in Tissue Regeneration: A Systematic Review of Clinical Evidence and Mechanistic Insights
This review synthesizes recent PubMed-indexed evidence on autologous blood-derived therapies, such as PRP and PRF, highlighting their role in accelerating wound healing through growth factor signaling and cellular recruitment.
Treatment Evolution in 5q-Spinal Muscular Atrophy: Real-World Evidence and Clinical Insights from the SMArtCARE Registry
This review analyzes the shifting landscape of SMA therapy using data from 2,140 patients, highlighting the transition between nusinersen, risdiplam, and onasemnogene abeparvovec and the factors driving treatment switches.
Mapping the Genomic Landscape of Multiple Sclerosis Across Diverse Ancestries: Insights into Shared and Population-Specific Susceptibility
This study demonstrates that while MS genetic risk factors are largely shared across ancestral groups, their predictive power and population-level impact vary significantly between European, South Asian, and African populations.
Low-Dose Lithium for Mild Cognitive Impairment: A Pilot Randomized Clinical Trial and Synthesis of Emerging Neuroprotective Paradigms
This review evaluates a recent 2-year pilot RCT on low-dose lithium carbonate for MCI, synthesizing its findings with emerging evidence on Aβ clearance, gut-brain axis modulation, and multimodal disease forecasting.
Comparative Diagnostic Performance of Global Thyroid Ultrasound Risk Stratification Systems: The Impact of Nodule Size and Lexicon Standardization
This review synthesizes findings from a large-scale comparison of five major thyroid ultrasound risk stratification systems (RSSs), evaluating how nodule size and standardized lexicon influence sensitivity, specificity, and unnecessary biop
Preventive PCI for Non-Flow-Limiting Vulnerable Plaques: Paradigm Shift or Preemptive Risk?
This evidence-based review examines the debate over adding preventive PCI to medical therapy for vulnerable plaques, analyzing the PREVENT trial results and the role of intracoronary imaging in risk stratification.
Beyond Traditional Risk Factors: Deconstructing the Burden of Coronary Atherosclerosis in Liver Transplant Recipients
A landmark nationwide study reveals that liver transplant recipients face significantly higher prevalence and severity of coronary atherosclerosis and high-risk plaque compared to matched controls, independent of traditional cardiovascular
Optimizing Immunotherapy in Cholangiocarcinoma: Low-Dose Chemotherapy as a Catalyst for Immune Microenvironment Remodeling
This review examines how low-dose gemcitabine and cisplatin (LDGC) synergize with anti-PD-L1 therapy in intrahepatic cholangiocarcinoma by reprogramming immunosuppressive SPP1+ macrophages and enhancing CD8+ T-cell cytotoxicity through STAT
Age at Onset and Clinical Trajectory in AQP4-IgG NMOSD: Decoupling Relapse Risk from Disability Accrual
This review analyzes how age at onset influences NMOSD, revealing that while relapse risk remains constant across age groups, older onset significantly accelerates disability progression, necessitating early high-efficacy therapy.
Rethinking Rhythm Control for Secondary Stroke Prevention: Insights from the STABLED Randomized Clinical Trial
This review analyzes the STABLED trial findings alongside major AFib rhythm control studies, evaluating the efficacy and safety of catheter ablation added to DOAC therapy for secondary stroke prevention.
Revisiting Pharmacotherapy in Nonobstructive Hypertrophic Cardiomyopathy: Insights from a Randomized Triple-Crossover Trial of Bisoprolol vs. Verapamil
A pivotal triple-crossover RCT reveals that while bisoprolol reduces exercise capacity and worsens diastolic markers in nonobstructive HCM, verapamil maintains exercise performance and improves myocardial strain.
Browse by specialty
Open language-specific specialty feeds and department pages.