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Deep capillary plexus ischemia quantified by geometric perfusion deficit predicts earlier and higher risk of diabetic retinopathy complications than foveal avascular zone enlargement, underscoring GPDd’s clinical utility as a biomarke
The CLEAN trial shows intravenous nicorandil adjunctive to primary PCI does not significantly improve 12-month clinical outcomes in STEMI. Evidence suggests microvascular benefits but no consistent long-term mortality or infarct size reduct
This review synthesizes current evidence on upadacitinib for alopecia areata, focusing on long-term efficacy, safety, and predictors of treatment response, highlighting the real-world retrospective study by Wang et al. alongside emerging cl
This review synthesizes evidence linking smartphone acquisition and use at age 13 to depression, obesity, and sleep insufficiency at age 14, highlighting that use intensity rather than mere acquisition mediates health risks, with behavioral
This review synthesizes evidence highlighting the high prevalence and interrelation of sleep disturbances, mood symptoms, and cognitive impairments in chronic mild traumatic brain injury (mTBI), emphasizing the need for integrated assessmen
Cryptogenic steatotic liver disease (SLD), representing a lean phenotype without classic cardiometabolic risk factors, is associated with adverse liver profiles and higher liver-related mortality, highlighting an underrecognized high-risk s
Experience-based continuous glucose monitoring (CGM) curricula significantly improve internal medicine residents’ confidence in applied patient care skills compared to traditional approaches, supporting hands-on CGM training integrati
Medicare Advantage (MA) shows no significant improvement over original Medicare (OM) in managing type 2 diabetes outcomes or mitigating related social needs despite higher costs, underscoring the need for effective spending strategies.
This review synthesizes evidence regarding the safety, efficacy, and clinical outcomes of TEAM versus BEAM conditioning regimens in autologous transplantation for lymphoma, integrating data from randomized trials and meta-analyses to inform
Meconium aspiration syndrome (MAS) significantly increases the risk of preschool asthma and bronchiolitis by disrupting neonatal airway development, highlighting the need for early respiratory monitoring and intervention strategies.
This review synthesizes current evidence on menopausal hormone therapy’s cost-effectiveness, highlighting findings from a 2026 Markov model analysis and contextualizing with pivotal studies on health outcomes and economic implications
Levothyroxine treatment in older adults with subclinical hypothyroidism shows limited impact on cardiometabolic biomarkers overall but may benefit those with higher TSH levels, highlighting nuanced treatment implications and the need for ta
COMBINE 4 demonstrated that once-weekly IcoSema (icodec+semaglutide) offers superior glycemic control, weight reduction, and reduced hypoglycemia versus daily insulin glargine U100 in insulin-naive type 2 diabetes patients, supported by com
This review integrates recent randomized trial data with observational studies to clarify cannabis inhalation’s acute impact on cardiac ectopy, physical activity, sleep, and glucose, highlighting complex arrhythmia associations and cl
This review synthesizes evidence linking NOAC use to slower cognitive decline and improved clinical outcomes in patients with atrial fibrillation and Alzheimer’s disease, highlighting advantages over warfarin and non-use.
Vutrisiran, an RNA interference therapeutic, significantly improves cardiac function, reduces amyloid burden, and attenuates disease progression in transthyretin amyloid cardiomyopathy as revealed by multiparametric cardiovascular MRI and c
A landmark randomized trial demonstrates that multilevel stepped reminders targeting both primary care physicians and patients markedly improve adherence to annual lung cancer screening, while health communication alone may be insufficient
This review synthesizes evidence on combining lenalidomide and oral azacitidine with radiotherapy for plasmacytoma, highlighting safety, preliminary efficacy, and translational rationale in newly diagnosed and relapsed patients.
This review synthesizes evidence revealing l-carnitine’s pivotal role in human hematopoietic stem and progenitor cell regeneration via fatty acid oxidation, highlighting metabolic profiling advances and translational potential for reg
This review synthesizes evidence on dual-sided composite defocus (DSCD) spectacle lenses, demonstrating significant myopia progression reduction and axial elongation control in children, contextualized within broader spectacle-based interve
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