Section
This study compares a rule-based computable phenotype with a large language model for detecting opioid use disorder in emergency department records, highlighting strengths in sensitivity and specificity for each method and implications for
Admission dysphagia screening using a nurse-led protocol was associated with a significant reduction in hospital-acquired aspiration pneumonia among general ward patients, highlighting its role in preventative hospital care.
Reduced expression of splicing factor SRSF1 disrupts LCK exon 8 inclusion, impairing TCR signaling and regulatory T-cell induction, thereby contributing to immune dysregulation in immune thrombocytopenia.
In patients with suspected obstructive sleep apnea, increased respiratory effort measured by negative esophageal pressure during sleep independently predicts long-term mortality beyond traditional markers, underscoring its clinical importan
This review synthesizes recent evidence demonstrating that glaucoma polygenic risk scores (PRS) enhance risk stratification and prognosis, outperforming family history, and supporting PRS-guided screening and management interventions.
Completion thyroidectomy performed after an interval shows superior parathyroid preservation and lower postoperative hypocalcemia risk compared to initial total thyroidectomy, supporting a staged surgical approach for optimized safety.
This randomized trial demonstrates that periurethral estradiol cream application is noninferior to intravaginal application for preventing recurrent urinary tract infections in postmenopausal individuals, with comparable efficacy and improv
This national cohort study reveals that intravenous albumin administration after outpatient paracentesis significantly reduces hospitalization rates for acute kidney injury, especially in cirrhotic patients with impaired renal function.
This multicenter study shows cenobamate is effective and safe as adjunctive therapy for refractory focal-onset status epilepticus, improving seizure control and outcomes.
The ATTAIN-J trial demonstrated that once-daily oral orforglipron significantly reduced bodyweight with a favorable safety profile in Japanese adults with obesity disease, aligning with global findings on GLP-1 receptor agonists.
This article reviews the SEASON-AR trial demonstrating that TAVR plus medical therapy significantly reduces death, disabling stroke, and heart failure rehospitalization at one year compared to medical therapy alone in high-risk patients wit
FGFR alterations, especially in FGFR3 and FGFR2, are pivotal biomarkers in urothelial carcinoma, advancing personalized diagnosis, treatment, and monitoring across disease stages. Emerging molecular diagnostics and targeted therapies promis
Different cardiopulmonary exercise testing prediction equations yield widely variable percent-predicted values for peak oxygen uptake, leading to frequent reclassification of exercise performance influenced mainly by body mass index, age, a
This prospective multicenter study highlights the persistence of chronic pain and pruritus up to one year after burn injury and identifies PTSD symptoms as a significant risk factor, underscoring the need for integrated psychosomatic rehabi
This study elucidates how Porphyromonas gingivalis-induced neutrophil extracellular traps (NETs) contribute to neuroinflammation and cognitive impairment through TLR4 activation, revealing a mechanistic link between periodontitis and Alzhei
A landmark multicenter randomized trial reveals that first-line IVF yields higher live-birth rates than IUI with ovarian stimulation in unexplained infertility, with cumulative outcomes equalized after subsequent cycles.
The LITMUS study evaluates non-invasive biomarkers for diagnosing metabolic dysfunction-associated steatotic liver disease, highlighting proteomic panels’ promise in detecting at-risk steatohepatitis and fibrosis stages, potentially r
Early primary care follow-up within 7 days after pediatric ICU discharge is significantly associated with reduced acute care use, including emergency visits and rehospitalizations, highlighting a critical opportunity to improve post-critica
This phase 2 randomized trial demonstrates that IL-4-receptor-α blockade with dupilumab significantly improves clinical outcomes and reduces fibrosis-associated inflammation and gene signatures in localised scleroderma, supporting a novel t
This article reviews the Dallas Uterus Transplant Program’s rigorous living donor evaluation process, highlighting its critical role in optimizing donor safety and recipient success in uterus transplantation.
