Our website uses essential cookies and, with your consent, additional cookies to measure performance and improve our services. Cookie Policy.
You can change your choice at any time.
This study reveals that despite long-term remission in Cushing’s disease, substantial plasma protein abnormalities persist, particularly in coagulation and complement systems, potentially contributing to ongoing health risks.
This study investigates three-year continuous glucose monitoring trajectories across clinical subgroups of adults with type 1 diabetes to identify factors influencing glycemic control and variability, highlighting the need for individualize
This study reveals that polyendocrine metabolic ovarian syndrome (PMOS) during pregnancy increases risks of early gestational diabetes and adverse neonatal outcomes, underscoring the need for timely identification and management to improve
A cluster-randomized trial demonstrates that integrating best practice advisories (BPAs) and standing orders into electronic health records significantly improves referral rates to diabetes self-management education and support (DSMES) over
Semaglutide demonstrates consistent cardiovascular benefits and safety across frailty levels in overweight adults with cardiovascular disease, enhancing quality of life and frailty status without increased adverse events.
This meta-analysis of 87 randomized trials finds that increasing whole-grain intake is associated with improved cardiometabolic risk factors including reduced body weight, cholesterol, and blood pressure, particularly at daily intakes of 60
Left ventricular pressure overload induces metabolic vulnerability that heightens susceptibility to anthracycline cardiotoxicity, revealing a critical need for targeted preventive strategies in patients with hypertension or valvular disease
PDS0101 combined with pembrolizumab demonstrated encouraging efficacy and safety in immune checkpoint inhibitor-naive HPV16-positive recurrent/metastatic head and neck squamous cell carcinoma, supporting further first-line evaluation.
A meta-analysis reveals immune checkpoint inhibitors may reduce survival in head and neck squamous cell carcinoma patients with PD-L1 combined positive scores less than 1, signaling caution in this subgroup’s treatment.
This study reveals that angiotensin II via TGF-β1 upregulates platelet PAR4, promoting hyperactivation and thrombosis in hypertension, with valsartan attenuating this pathway and thrombotic risk.
Low-dose rivaroxaban failed to reduce cardiovascular events but increased major bleeding in advanced CKD patients at high cardiovascular risk, underscoring the need for cautious anticoagulant use.
This article explores how PD-L1 and PD-L2 differentially regulate immune and lineage-specific programs in primary mediastinal large B-cell lymphoma, providing insights for tailored immunotherapy.
This study identifies neutrophil-dependent type-I interferon responses and NETs as key drivers of joint damage in hemophilia A, opening avenues for novel therapies to prevent hemophilic arthropathy.
The ST120 strain of Mycobacterium massiliense, prevalent in East Asia, exhibits unique genetic features linked to increased virulence and worse treatment outcomes in pulmonary disease.
The Phase 3 LYNX-1 trial demonstrates that 0.75% phentolamine ophthalmic solution improves mesopic low-contrast visual acuity and reduces photic symptoms in patients with dim light vision disturbances, including those post-keratorefractive
LINC01521 is significantly upregulated in papillary thyroid carcinoma, promoting tumor progression by targeting miR-4319 and inhibiting cuproptosis, thereby serving as an independent prognostic marker for adverse clinical outcomes.
This article reviews advances in liver xenotransplantation using genetically modified porcine organs as a bridging strategy for acute liver failure, highlighting recent clinical progress, challenges, and future directions.
This study elucidates how intestinal blood vessel-associated macrophage dysfunction contributes to gut-vascular barrier breakdown and bacterial translocation in cirrhosis, revealing novel mechanisms that underlie systemic infection risks in
This article reviews the establishment of international standardized reference ranges for plasma estradiol in postmenopausal women, highlighting the influence of BMI and assay harmonization using CDC standards, with implications for therapy
Breast cancer independently increases atrial fibrillation risk via tumour-secreted ADAM10, which induces atrial fibrosis through the Ephrin B2 signaling pathway, offering a potential new therapeutic target.
Open language-specific specialty feeds and department pages.