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Risk Factor-Weighted Clinical Likelihood in Suspected Chronic Coronary Syndrome: Useful First-Step Triage, but Not the Whole Diagnostic Story
The 2024 ESC-endorsed RF-CL model improves estimation of obstructive CAD probability in symptomatic patients, safely reducing unnecessary testing, but symptom ambiguity, qualitative upper ranges, and limited capture of ischemia without obst
Finerenone May Lower Sudden Death Risk Across the Cardio-Kidney-Metabolic Continuum
A prespecified pooled analysis of 18,991 participants found finerenone was associated with a significant reduction in sudden death across chronic kidney disease, type 2 diabetes, and heart failure populations.
SRPK3-Driven TPM1 Splicing Emerges as a Myofilament Mechanism of Diastolic Dysfunction in HFpEF
A Circulation study identifies SRPK3-mediated alternative splicing of TPM1 exon 9a as a driver of myofibrillar disarray, reduced myocardial compliance, and diastolic dysfunction in HFpEF, highlighting a potential disease-modifying therapeut
Impact of Population-Based Pathogenic Variant Testing on Risk-Based Breast Screening Recommendations: A Secondary Analysis of the WISDOM Study
This WISDOM Study analysis found that most women with breast cancer pathogenic variants would not have been flagged for high-risk screening by clinical or polygenic risk models alone, supporting population-based genetic testing.
Millions of Americans Still Live Beyond Timely Reach of Registered Replantation Centers
A U.S. geospatial analysis found major state-level disparities in access to registered hand trauma centers, with 13.3% of the population outside a 6-hour catchment and 7.6% still uncovered at 12 hours.
Serial Dependence in Working Memory Distinguishes Schizophrenia From Bipolar Disorder With Psychosis
A multisite case-control study found repulsive serial bias in schizophrenia, attractive bias in healthy controls, and mixed patterns in bipolar disorder, supporting serial dependence as a potential cognitive biomarker across the psychosis s
Remote Respiratory Therapy Safely Replaced Most Bedside Ventilator Care in a Donor Center ICU
A prospective study found that fully remote respiratory therapy in a donor care ICU was feasible, safe, and labor-saving, with minimal need for bedside support and favorable organ recovery outcomes.
Emergency Medicine Training Must Evolve for a Permanently Crowded, Boarded ED
A 2026 Annals commentary argues that boarding and crowding are enduring emergency department realities and that residency education should shift from avoidance to deliberate preparation for safe, effective practice in constrained systems.
Telehealth Navigation and Remote Blood Pressure Monitoring Were Linked to Better Hypertension Control in Black Patients at Federally Qualified Health Centers
An observational study in a Massachusetts FQHC network found that a telehealth navigator program with remote monitoring was associated with a substantial improvement in blood pressure control among Black adults with hypertension.
Primary vs Specialist Palliative Care in End-Stage Liver Disease: Interpreting the 2026 Cluster Randomized Trial in the Broader Evidence Base
A major 2026 cluster randomized trial shows that palliative care delivered by trained hepatologists is noninferior to specialist palliative care for improving quality of life in end-stage liver disease, supporting scalable integrated models
The Sieve of Asclepius: A History of Navigating the Medical Literature, From Index to Algorithm
A historically grounded review of how physicians, librarians, publishers, and now algorithms have filtered the expanding medical literature, shaping what counts as visible, credible, and clinically actionable knowledge.
Fludarabine Dose Intensity, Lymphodepletion Biology, and Product-Specific Outcomes in Large B-Cell Lymphoma CAR-T Therapy: Interpreting the 2026 EBMT Registry Analysis
A large EBMT registry study suggests that escalating fludarabine during lymphodepletion does not improve tisagenlecleucel outcomes in LBCL and may worsen survival, while axicabtagene ciloleucel retains superior efficacy at standard dosing b
Pre-diagnostic Clonal Hematopoiesis Raises Risk of Second Cancers in Patients With Primary Cancer
Patients with primary cancer who had pre-diagnostic CHIP faced a higher risk of second cancers, especially blood cancers. The findings suggest CHIP may help identify survivors who need closer long-term monitoring.
Targeting Post-Transplant Myeloid Immune Suppression in Multiple Myeloma: Why CSF-1R Blockade May Enhance Lenalidomide Maintenance After ASCT
A new Blood study links relapse after myeloma ASCT to CSF-1R+ immunosuppressive marrow macrophages and shows that CSF-1R inhibition synergizes with lenalidomide in preclinical models, providing a strong translational rationale for post-tran
Bronchoscopy in Germany Generates More Than 550 Tons of Waste Annually, With Reusable PPE Offering the Largest Immediate Reduction
A multicenter German study shows pulmonary endoscopy produces substantial waste, much of it in procedure rooms, and suggests reusable gowns, procedural bundling, and recycling as practical ways to lower environmental impact.
Quantitative CT Progression Thresholds in Idiopathic Pulmonary Fibrosis May Sharpen Annual Monitoring and Risk Stratification
A multicenter study suggests that 1-year quantitative CT fibrosis progression in IPF, particularly a rise of about 4%, is clinically meaningful and prognostically informative for transplant-free survival.
Subclinical Peripheral Vascular Leakage in Demyelinating Disease-Associated Uveitis: What Ultra-Widefield Angiography Adds Beyond Clinical Quiescence
A new cohort study suggests ultra-widefield fluorescein angiography frequently detects persistent peripheral leakage in clinically inactive demyelinating disease-associated uveitis, highlighting a potential gap between examination-based rem
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