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RETREAT Score Stratifies Long-Term Hepatocellular Carcinoma Recurrence Risk After Liver Transplantation in Real-World Practice
A single-center validation study shows the RETREAT score reliably predicts long-term HCC recurrence after liver transplantation and identifies patients with markedly different recurrence-free and overall survival trajectories.
Finerenone Shows Consistent Cardiovascular and Kidney Benefit Across CKM Syndrome Stages in Type 2 Diabetes and CKD
A post hoc FIDELITY analysis suggests finerenone improves cardiovascular and kidney outcomes across CKM stages and may modestly shift patients toward CKM regression over time.
Diabetes Markedly Raises Sudden Cardiac Death Risk, With the Greatest Excess Hazard in Younger Adults
A Danish nationwide study found substantially higher sudden cardiac death rates in both type 1 and type 2 diabetes, especially at younger ages, with meaningful loss of life expectancy attributable to sudden cardiac death.
Diabetes and Sudden Cardiac Death: Findings from a Danish Nationwide Study
A nationwide Danish study found that type 1 and type 2 diabetes substantially increase sudden cardiac death risk, especially in younger adults, and contribute meaningfully to shortened life expectancy.
COAPT’s Benefit With MTEER Appears Transportable to Contemporary U.S. Practice in Secondary Mitral Regurgitation
A transportability analysis suggests the benefits seen in COAPT would likely persist in real-world U.S. patients with secondary mitral regurgitation if COAPT-style care, including optimized medical therapy, were delivered.
First-Line Serplulimab in Extensive-Stage Small Cell Lung Cancer: Secondary Analysis of the ASTRUM-005 Phase 3 Randomized Clinical Trial
Extended follow-up from ASTRUM-005 shows serplulimab plus chemotherapy improves long-term survival in untreated extensive-stage small cell lung cancer, with manageable safety and encouraging patient-reported outcomes.
Personalized Automatic Management of Tracheal Cuff Pressure and Subglottic Secretion Drainage to Prevent Pneumonia in Critically Ill Intubated Patients: The MICROINHALO Multicenter Randomized Controlled Trial
MICROINHALO found that automatic cuff pressure control plus subglottic secretion drainage did not reduce tracheal colonization, but it was linked to fewer ventilator-associated pneumonia cases in critically ill intubated patients.
European ECLS End-of-Life Practices Vary Widely, Exposing Gaps in Ethics and Palliative Support
A large European survey found major regional and cultural differences in how clinicians approach ECLS withdrawal, with limited access to ethics and palliative care support in many institutions.
Routine Laboratory Testing Rarely Improves Emergency Department Medical Screening for Adult Psychiatric Presentations
A 145-publication scoping review finds that ED medical screening of adults with psychiatric complaints is dominated by low-level evidence, with society statements generally discouraging routine laboratory testing in otherwise low-risk patie
Point-of-Care Ultrasound in Acute Care Did More Than Diagnose: It Reassured Patients, Reduced Burden, and Deepened Trust
A qualitative study found that patients experienced point-of-care ultrasound as emotionally reassuring, physically convenient, and closely tied to physician communication and trust during acute care.
Deprescribing Intervention Reduces Proton Pump Inhibitor Use in Primary Care
A large primary care trial found that a combined patient- and GP-focused deprescribing intervention safely reduced long-term proton pump inhibitor use more effectively than usual care or GP-only education.
Off-the-Shelf, Non-Gene-Edited Allogeneic CD19 CAR-T Cells Show Early Feasibility in Relapsed or Refractory B-ALL
A phase 1 study suggests non-gene-edited allogeneic CD19 CAR-T therapy can induce remissions in relapsed or refractory B-ALL without observed GVHD, though durability remains limited and larger trials are needed.
Checkpoint Inhibition Is Reshaping Pediatric Lymphoma Care, Led by Breakthroughs in Hodgkin Lymphoma and Expanding into PD-L1–Positive Non-Hodgkin Subtypes
Immune checkpoint therapy has become a major advance in pediatric Hodgkin lymphoma and is now being actively tested across selected pediatric non-Hodgkin lymphomas with strong PD-L1 biology.
Loss of the Fibrinogen αC Region, Rather Than Hypofibrinogenemia Alone, Attenuates Experimental Arterial Thrombosis
Mouse and human observational data suggest that the fibrinogen αC region is a key determinant of arterial thrombosis under hypofibrinogenemic conditions, likely through platelet GPVI-dependent mechanisms.
A Chest X-Ray AI Age Gap May Flag Early Spirometric Decline Before Overt Lung Disease
In a large Korean health-screening cohort, chest radiograph-derived age acceleration was associated with both prevalent and incident PRISm and obstructive lung disease, supporting chest X-ray AI as a potential opportunistic marker of early
Negative End-Expiratory Transpulmonary Pressure, Lung Collapse, and Non-Focal ARDS Drive Tidal Recruitment During Pressure Support Ventilation
In spontaneously breathing ARDS patients on pressure support ventilation, tidal recruitment/derecruitment was strongly linked to more negative end-expiratory transpulmonary pressure, greater collapse, and non-focal infiltrates, while EIT-gu
Most Open-Angle Glaucoma Suspects Convert at Less Than 6% Per Year After Year 1, Supporting Risk-Stratified Follow-Up
A large US claims-based cohort suggests that most open-angle glaucoma suspects have modest annual conversion risk after the first year, and that age- and treatment-informed surveillance intervals may help tailor follow-up intensity.
Veligrotug Delivers Rapid, Durable Benefit in Active Thyroid Eye Disease in the Phase 3 THRIVE Trial
In phase 3 testing, veligrotug produced rapid and clinically meaningful reductions in proptosis, diplopia, and disease activity in active thyroid eye disease, with durable benefit through 52 weeks and a favorable short-term safety profile.
Higher Oral Corticosteroid Exposure in Chronic Rhinosinusitis With Nasal Polyps Is Linked to More Systemic Harm
A nationwide Korean nested case-control study found that longer annual duration and higher cumulative oral corticosteroid dose in chronic rhinosinusitis with nasal polyps were associated with increased systemic adverse events, supporting st
Routine Hospitalist Co-Management After Head and Neck Free Flap Surgery Was Linked to Fewer Escalations of Care, but Not Shorter Stay or Lower Mortality
In a retrospective cohort of 362 head and neck free tissue transfer patients, routine hospitalist involvement was associated with fewer transfers to a higher level of care, without significant effects on length of stay, readmission, or 90-d
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