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Open Globe Repair Carries the Highest Endophthalmitis Risk, and Pediatric Cataract Surgery Outpaces Adult Surgery in IRIS Registry Data
An IRIS Registry analysis of 17.5 million procedures found endophthalmitis was rare overall but highest after open globe repair, with pediatric cataract surgery carrying more risk than adult surgery.
Amivantamab Falls Short of Tumor Shrinkage in Recurrent or Metastatic Adenoid Cystic Carcinoma, but Disease Stabilization Was Common
In a phase 2 trial, amivantamab did not meet its primary response endpoint in recurrent/metastatic adenoid cystic carcinoma, but most patients achieved stable disease and toxicity was generally manageable.
Cartilage Ear Piercings Carry Nearly Double the Complication Risk of Lobule Piercings in a Large Adult Survey
In a large survey of adult ear piercings, auricular cartilage piercings had higher complication and removal rates than lobule piercings, reinforcing the need for careful counseling and informed consent.
Adequate Lymph Node Dissection May Carry a Survival Signal in Intrahepatic Cholangiocarcinoma
An updated meta-analysis suggests lymph node dissection in intrahepatic cholangiocarcinoma may improve survival when it is truly adequate, especially when at least six nodes are retrieved and confounding is reduced.
腹腔鏡と開腹手術による小腸閉塞癒着剥離の長期転帰：LASSO無作為化臨床試験
小腸閉塞手術における腹腔鏡アプローチは短期回復が早いが、5年間の追跡調査では再発率、ヘルニア発生率、QOLにおいて開腹手術と同等の結果を示した。術式選択は患者個別の要因に基づくべきである。
Maryland’s Global Budget Revenue Model Was Linked to Better Cancer Surgery Outcomes and Lower Medicare Spending
In a large Medicare study, hospitals under Maryland’s global budget model showed modest but significant improvements in cancer surgery outcomes, driven by fewer complications and shorter stays, with lower inpatient spending.
Prophylactic Antibiotics Did Not Significantly Reduce Infection After Vulvar Surgery, Cohort Study Finds
In a prospective cohort of 172 vulvar surgery patients, prophylactic antibiotics were not associated with fewer postoperative infections or complications, supporting the need for a randomized trial.
A New Dutch Prediction Model Identifies Nulliparous Women at Higher Risk of Obstetric Anal Sphincter Injury
A Dutch nationwide study developed and temporally validated two OASI risk models for nulliparous women, with moderate discrimination but excellent calibration. The models may help target counseling and preventive obstetric strategies.
Biallelic ANAPC13 Mutations Identify a New Genetic Cause of Oocyte Maturation Arrest
Biallelic ANAPC13 variants caused metaphase I oocyte maturation arrest in three women and in a knock-in mouse model, implicating APC/C dysfunction as a new monogenic cause of female infertility.
Genetic Discovery: ANAPC13 Mutations Cause Female Infertility Through Oocyte Maturation Arrest
Researchers identified biallelic ANAPC13 mutations as a genetic cause of female infertility characterized by oocyte maturation arrest. The study demonstrated how these mutations disrupt cell division in both humans and mice, and explored a
ANAPC13 Mutations Emerge as a New Genetic Cause of Oocyte Maturation Arrest
Biallelic ANAPC13 mutations were linked to metaphase I oocyte maturation arrest in humans and mice, implicating APC/C dysfunction as a new genetic cause of female infertility and a potential future target for rescue strategies.
OCE-205 Signals a Potential New Direction for Hepatorenal Syndrome-AKI, with Tolerability at the Center
In a phase 2 randomized trial, OCE-205 improved HRS-AKI in more patients than placebo and showed no excess ischemic or respiratory toxicity, but the study was underpowered after early termination.
A Blood-Based Extracellular Vesicle RNA Signature May Offer a New Way to Diagnose Chronic Pancreatitis
A five-RNA extracellular vesicle signature showed strong diagnostic performance for chronic pancreatitis and may also reflect acinar-to-ductal metaplasia and disease-related metabolic features.
Even the Largest Stroke Cores May Benefit from Thrombectomy, LASTE Ancillary Analysis Suggests
In patients aged under 80 with ASPECTS 0-2, endovascular thrombectomy improved disability outcomes and reduced mortality versus medical care alone, challenging the idea that very large infarcts should automatically exclude treatment.
Corticostriatal Connectivity Reorganizes Before and After Motor Decline in Parkinson Disease
Resting-state MRI and PET data suggest that corticostriatal networks remodel across nigrostriatal degeneration in Parkinson disease, with posterior caudate hyperconnectivity preceding major motor decline and posterior putaminal disconnectio
DASH and Other Healthy Diets Linked to Lower Cognitive Decline Risk in Large U.S. Cohorts
In two large U.S. cohorts, greater adherence to healthy dietary patterns—especially DASH—was associated with less subjective cognitive decline and slightly better objective cognition.
Restrictive Thyroid Incidentaloma Guidelines Cut Workload Dramatically but Miss a Small Number of Low-Risk Cancers
Conventional imaging-detected thyroid incidentalomas rarely prove malignant. A retrospective study found restrictive guidelines can sharply reduce unnecessary workup, though a small number of low-risk cancers may be missed.
Genetic Variant Modulates Dietary Impact on Glucose Control: Inuit Study Reveals Key Insights
A Greenlandic study shows that Inuit with a specific sucrase-isomaltase gene variant have better glucose regulation on a Western diet compared to non-carriers, suggesting potential new diabetes treatments.
Validation of the 2025 ATA Risk Stratification System in a Cohort of Patients with Papillary Thyroid Carcinoma
A real-world study validates the 2025 ATA thyroid cancer risk guidelines, showing significant patient reclassification and identifying a new ‘low-intermediate-risk’ group needing tailored management approaches.
2025 ATA Risk Stratification for Papillary Thyroid Cancer: Validation Study Reveals Significant Reclassification Shifts
A retrospective study of 670 papillary thyroid carcinoma patients validates the 2025 ATA risk stratification system, demonstrating a shift toward higher-risk classifications. The new ‘low-intermediate-risk’ class emerges as a distinct entit
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