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Retinal Nerve Fiber Layer Thickness at 36 Weeks May Help Predict 2-Year Neurodevelopment in Very Preterm Infants
In very preterm infants, thicker retinal nerve fiber layer on OCT at 36 weeks’ postmenstrual age was associated with better motor and cognitive outcomes at 2 years, supporting retinal imaging as a potential early neurodevelopmental biomarke
Retinal OCT as an Early Window into Brain Development in Very Preterm Infants: Interpreting 36-Week Microanatomy for 2-Year Neurodevelopment
A new prospective cohort study suggests that retinal nerve fiber layer thickness on neonatal OCT at 36 weeks’ PMA may help predict 2-year motor and cognitive outcomes in very preterm infants.
Poor Glycemic Control and Higher Blood Pressure Track With Early Diabetic Retinal Disease in Youth With Type 1 Diabetes
A large retrospective study links higher HbA1c and elevated blood pressure to diabetic retinopathy in youth with type 1 diabetes, while worse glycemia also correlates with thinner inner retinal layers suggestive of early neurodegeneration.
Area-Level Socioeconomic Disadvantage Is Linked to Worse Pretreatment Head and Neck Cancer–Specific Quality of Life
In patients with head and neck cancer, living in the most socioeconomically disadvantaged areas was associated with poorer pretreatment head and neck cancer–specific quality of life, while associations with other quality-of-life domains wer
Topical Nitroglycerin Ointment Shows Early Symptom Benefit in Empty Nose Syndrome
In a preliminary clinical study, topical nitroglycerin ointment improved ENS6Q scores and dryness symptoms in patients with empty nose syndrome, with mostly mild adverse effects.
Histotripsy for Neuroendocrine Liver Metastases: Early Clinical Signals, Safety Lessons, and the Road to Broader Adoption
An early single-institution series suggests histotripsy may offer noninvasive local control for neuroendocrine liver metastases, with complete response after full-coverage treatment but important safety concerns, particularly acute kidney i
Cold Knife Conization Was Linked to Lower Long-Term Cervical Lesion Recurrence Than LEEP in Two Real-World Cohorts
In Swedish and Chinese cohorts, cold knife conization was associated with lower recurrent cervical lesion risk and faster HPV clearance than LEEP, although important questions remain about residual confounding, obstetric trade-offs, and pro
AI Model Shows Moderate Accuracy for Predicting Complete Response After Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer
A fine-tuned ensemble of tabular foundation models moderately predicted pathological complete response after TNT and showed potential to support watch-and-wait selection after recalibration.
Homologous Recombination Repair Gene Alterations Are Uncommon and Not Prognostic in Molecularly Classified Endometrial Cancer
In a 298-patient endometrial cancer cohort, HRR gene alterations were rare, enriched in aggressive tumor subsets, but did not predict survival or platinum sensitivity beyond integrated molecular classification.
Cesarean Scar Pregnancy Continued Beyond the First Trimester Carries High Risks of Pregnancy Loss, Placenta Accreta Spectrum, and Hysterectomy
International registry data show that expectant management of live cesarean scar ectopic pregnancy is frequently followed by second-trimester loss, placenta accreta spectrum, and peripartum hysterectomy, with first-trimester ultrasound mark
Fibroids Do Not Uniformly Regress After Menopause: Reframing Leiomyoma Care Across the Menopausal Transition
A contemporary review shows that uterine leiomyomas often persist across menopause, requiring symptom-driven evaluation, structured imaging, and individualized management rather than assumptions of spontaneous regression.
Chronic Kidney Disease Worsens Short-Term Outcomes in Hospitalized Patients With Cirrhosis Across a Global Cohort
In a large international prospective cohort of hospitalized patients with cirrhosis, chronic kidney disease was common, clustered with metabolic risk, and strongly associated with acute kidney injury, more decompensation, and higher in-hosp
Computer-Aided Detection Increased Adenoma Detection in a Large Pragmatic Cluster Randomized Colonoscopy Study
In a large Veterans Health Administration cluster randomized study, CADe availability increased adenoma detection during colonoscopy without changing withdrawal time or nonadenomatous lesion detection.
Ultra-High-Resolution Photon-Counting CTA Improves Noninvasive Detection of Neurovascular In-Stent Restenosis
A prospective study suggests ultra-high-resolution photon-counting CTA can detect neurovascular in-stent restenosis with excellent accuracy while reducing blooming artifacts and improving visualization of in-stent pathology.
Neurocognitive Outcomes of In Utero Exposure to Antiseizure Medication: An Australian Cohort Study
An Australian cohort study found that prenatal exposure to valproate, levetiracetam, topiramate, and carbamazepine was associated with poorer cognitive outcomes in children, while lamotrigine exposure was not.
A Two-Marker Plasma Model Closely Mirrors PET-Based Biological Staging of Alzheimer Disease
Plasma %p-tau217 plus eMTBR-tau243 showed strong agreement with amyloid/tau PET staging, tracked clinical severity, and aligned with neuropathology, supporting a scalable blood-based approach to Alzheimer disease biological staging.
Prevalence and Clinical Characteristics of Macro-TSH in Patients with Subclinical Hypothyroidism
Macro-TSH was rare but clinically important in patients with subclinical hypothyroidism, sometimes mimicking true thyroid disease and leading to unnecessary levothyroxine use. Specialized testing confirmed multiple immunoglobulin-linked TSH
Swedish Population Data Suggest SARS-CoV-2 Infection and COVID-19 Vaccination Do Not Confer a Sustained Causal Risk of New-Onset Type 1 Diabetes
In a nationwide Swedish cohort, type 1 diabetes diagnoses rose briefly after SARS-CoV-2 infection and first vaccine dose, but the signal was short-lived, supporting diagnostic acceleration rather than a durable causal effect.
Pituitary Adenoma Imaging as a Key Determinant of Acromegaly Diagnosis and Outcomes
High-quality pituitary imaging is essential for diagnosing and managing acromegaly, localizing somatotroph adenomas, guiding surgery or radiotherapy, and reducing treatment-related harm. A standardized, tiered MRI-based approach improves ac
Waist-to-Height Ratio Is Linked to Coronary Artery Disease Risk in Type 1 Diabetes: 19-Year Study
A 19-year Finnish cohort study found that a higher waist-to-height ratio was linked to increased coronary artery disease risk in type 1 diabetes, especially in people without albuminuria.
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