Decoding the Immune Landscape of COPD: Single-Cell RNA Sequencing Reveals Profibrotic Macrophage and Monocyte Niches Driving Disease Progression
Highlight
1. Single-cell RNA sequencing of bronchoalveolar lavage (BAL) cells from COPD patients reveals marked alterations in immune cell composition compared to healthy controls.
2. There is an increased abundance of proinflammatory and profibrotic macrophages, classical monocytes, and neutrophils in COPD airways, contributing to disease pathology.
MedXY registered readers
Sign in free to continue reading
Create or use your MedXY account to unlock the complete article.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.