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A 5-year real-world cohort study reveals that declines in CGM-derived time in range correlate with increased microvascular complications in type 1 diabetes, offering prognostic value beyond HbA1c.
This report discusses four patients with paternally inherited 15q11.2-q13 duplications linked to MKRN3 overexpression, presenting with delayed puberty and varying degrees of hypogonadism.
Long-read sequencing (LRS) improves genetic diagnosis of Congenital Adrenal Hyperplasia and other DSDs by resolving complex genomic variants, tightening phenotype-genotype correlations, and closing equity gaps in clinical care.
This study highlights how timing of palliative radiotherapy in gynecologic cancers influences end-of-life care quality, with late radiation associated with less aggressive care and better supportive outcomes compared to radiation administer
A recent study demonstrates the feasibility and safety of hybrid indocyanine green and technetium-99m nanoparticle fluorescence imaging for sentinel lymph node biopsy in early-stage vulvar cancer, improving detection rates and oncologic out
County-level social vulnerability significantly limits ovarian cancer clinical trial availability, underscoring structural inequities and the need for targeted strategies to improve trial access in vulnerable communities.
A multicenter prospective study comparing laparoscopic radiofrequency ablation and myomectomy in symptomatic uterine leiomyomas reveals both improve symptoms and quality of life, with myomectomy showing modest but clinically non-significant
A randomized clinical trial found that hip extension at crowning does not reduce significant perineal lacerations during first vaginal deliveries, with no clear benefit over usual flexed positioning.
The PORTOLA phase 2a trial evaluates zetomipzomib, a selective immunoproteasome inhibitor, demonstrating numerically improved biochemical remission and steroid-sparing effects in autoimmune hepatitis patients with inadequate response to sta
A focused summary of the 2026 international position statement offering practical, safety-first recommendations for continuing or initiating continuous glucose monitoring, insulin pumps, and automated insulin delivery in non‑critically ill
The ULYSSES trial demonstrates that ultrasound-guided femoral venous puncture markedly lowers vascular access complications compared to conventional palpation-guided techniques in patients undergoing atrial fibrillation ablation, enhancing
This trial evaluated whether atrioventricular node ablation improves outcomes of cardiac resynchronization therapy in heart failure patients with permanent atrial fibrillation, finding no significant benefit over medical rate control.
MTMR4 minor allele homozygosity influences arrhythmic risk oppositely in LQT1 and LQT2, providing critical insights for personalized risk stratification in long QT syndrome patients.
Left atrial mechanical dysfunction, particularly atrial electromechanical dissociation and impaired left atrial strain contraction, forecasts increased cerebrovascular events in transthyretin amyloid cardiomyopathy patients even in sinus rh
The EXCALIBUR study reveals significant arrhythmia incidence in cardiac amyloidosis (CA), highlighting subtype-specific arrhythmic profiles linked to myocardial amyloid burden, guiding risk stratification and management.
This study reveals that lifelong genetic differences in LDL cholesterol levels do not significantly affect the risk of venous thromboembolism (VTE), suggesting LDL-C may not be a major causal factor in VTE development.
This large nationwide study demonstrates that coronary CTA-derived FFR-CT strongly predicts future myocardial infarction, cardiovascular death, and revascularization, independent of traditional risk factors and stenosis severity, with a thr
This article examines the real-world safety and efficacy of the extravascular implantable cardioverter defibrillator (EV-ICD) over 1 year, demonstrating effective arrhythmia management and an acceptable safety profile in a large, global pat
Sotatercept improves right heart mechanics in patients with pulmonary arterial hypertension by decreasing right ventricular afterload and contractility in a balanced manner, enhancing right ventricular free wall function and right atrial pe
This review synthesizes evidence demonstrating disrupted gastrointestinal interoception in weight-restored anorexia nervosa, linking behavioral and neural disturbances with relapse risk and symptom severity, and highlighting novel mechanist
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