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This study examines how the 2016 CDC opioid prescribing guideline influenced opioid and gabapentinoid use in older adults with dementia, revealing shifts in analgesic prescribing patterns but uncertain effects on symptom management.
This article explores the surprising presence of conscious respiratory unpleasantness and dyspnea in adults with congenital central hypoventilation syndrome (CCHS) despite severely impaired central CO2 chemosensitivity, revealing potential
This review synthesizes evidence comparing brain atrophy patterns in MS, MOGAD, and AQP4+ NMOSD, highlighting MOGAD’s atrophy association with inflammatory activity and lesion dynamics, emphasizing distinct pathogenic mechanisms and c
This study reveals companionship as a key mediator between marital status and mental health outcomes in individuals with spinal cord injury, highlighting the importance of relationship quality for psychosocial well-being.
A landmark randomized trial demonstrates that atorvastatin reduces major cardiovascular events in adults aged 70 and older without established cardiovascular disease but does not extend disability-free survival, highlighting nuanced conside
A thorough review of systemic fluoroquinolone use reveals minimal association with peripheral neuropathy risk compared to cephalosporins, supported by large cohort studies and pharmacovigilance data, guiding safer antibiotic prescribing.
Loneliness in individuals with traumatic spinal cord injury correlates strongly with environmental barriers and depressive symptoms, highlighting the interplay of internal and external factors in mental health outcomes.
Study reveals disparities in home and outpatient rehabilitation access among older adults after traumatic brain injury, influenced by clinical needs and non-clinical factors such as ethnicity and rural residency.
A multicenter Chinese registry study demonstrates that direct oral anticoagulants are noninferior to warfarin in preventing 1-year symptomatic recurrent venous thromboembolism after cerebral venous thrombosis, with exploratory bleeding outc
A new machine learning model predicts post-rehabilitation walking ability in nontraumatic spinal cord injury patients with high accuracy, aiding early clinical decision-making and rehabilitation planning.
A virtual aerobic exercise program significantly improves recovery speed and quality of life in youth with prolonged concussion, especially when initiated within three months of injury, outperforming stretching interventions.
A pooled analysis from the PRIME database reveals distinct ventilatory management patterns and ARDS incidence in neurocritical versus non-neurocritical patients, highlighting key associations between ventilator settings and outcomes.
This study reveals that younger, non-Hispanic White patients with fewer comorbidities and lower socioeconomic vulnerability are more likely to receive antiamyloid medications for Alzheimer’s, while higher comorbidity predicts lower initial
A feasibility RCT demonstrates that a telehealth-delivered behaviour change intervention, augmented with a physical activity monitor, can increase physical activity in post-stroke individuals, supporting future large-scale trials.
MRI positivity in 52% of idiopathic acute unilateral audiovestibulopathy patients correlates significantly with vestibular deficits, particularly in the posterior canal, aiding diagnostic clarity and revealing pathophysiological insights.
A comprehensive meta-analysis of six US cohorts identifies vascular risk factors including smoking, hypertension, diabetes, chronic kidney disease, stroke history, and APOE ε4 genotype as significant predictors of late-onset epilepsy in old
A randomized controlled trial reveals that repetitive transcranial magnetic stimulation combined with vestibular rehabilitation significantly improves dizziness, balance, and postural stability in adults with chronic peripheral vestibular d
An international Delphi panel offers practical, evidence-informed recommendations for managing spontaneous intracranial hypotension with spinal longitudinal epidural CSF collections, clarifying peri-epidural blood patch practice, imaging ch
This study reveals significant hippocampal subfield volume reductions and white matter impairments in patients with congenital adrenal hyperplasia, highlighting sex-specific differences that could influence cognitive outcomes and treatment
This study evaluated whether 4 weeks of unilateral isometric elbow flexion resistance training induce adaptations in human reticulospinal tract function, finding no significant changes despite strength gains, thus informing neurorehabilitat
