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This nationwide Finnish cohort study reveals that gout increases ischemic stroke risk in atrial fibrillation patients, with urate-lowering therapy linked to reduced stroke incidence, underscoring gout’s potential role in stroke risk s
A prospective cohort study reveals that surgical or radiosurgical intervention for symptomatic cerebral cavernous malformations is linked with increased risks of severe functional impairment or death over long-term follow-up, underscoring t
Discovery of anti-CD320 autoantibodies links autoimmune vitamin B12 deficiency to idiopathic myelopathy, revealing a distinct clinical and radiographic profile with promising treatment implications.
A machine learning model using simple clinical tests within 72 hours poststroke accurately predicts 6-month upper-limb motor outcomes, aiding rehabilitation planning.
This review synthesizes recent evidence linking menopausal hormone therapy (MHT), particularly estrogen-only regimens, with decreased Alzheimer disease neuropathology and clinical dementia risk, highlighting biomarker correlations, clinical
This study reveals distinct thromboembolic, bleeding, and mortality risks based on antiseizure medication selection in epilepsy patients receiving direct oral anticoagulants, highlighting the critical role of ASM choice on patient safety an
Thrombus perviousness influences clinical outcomes in medium vessel occlusion strokes, with higher perviousness favoring intravenous thrombolysis and lower perviousness favoring endovascular therapy.
The NEAT phase 3 trial evaluated erythrocyte-encapsulated dexamethasone sodium phosphate in children with ataxia telangiectasia aged 6–9 years, confirming safety but failing to demonstrate statistically significant neurological improvement
Chorioamnionitis, especially with funisitis, attenuates fetal heart rate responses to hypoxia during labor, increasing susceptibility to hypoxic-ischemic encephalopathy at milder levels of acidemia in term fetuses.
Advanced MRI connectome analysis identifies disruption of key brain hubs as biomarkers predicting long-term seizure recurrence after temporal lobe epilepsy surgery, improving postoperative risk stratification.
Low-frequency repetitive transcranial magnetic stimulation targeting the medial prefrontal cortex reduces visceral pain and improves bowel symptoms in IBS-D by normalizing central neural hyperexcitability.
This study demonstrates that preoperative MRI-based disruption of brain hub connectivity predicts long-term seizure recurrence in temporal lobe epilepsy surgery patients, enhancing postoperative risk stratification beyond conventional clini
From 2013 to 2023, Medicare charges for inpatient neurologic care rose sharply while reimbursement increases lagged, widening payment gaps despite declining hospitalization volumes and highlighting systemic financial misalignments.
This review synthesizes evidence highlighting the high prevalence and interrelation of sleep disturbances, mood symptoms, and cognitive impairments in chronic mild traumatic brain injury (mTBI), emphasizing the need for integrated assessmen
Damage to serotonergic and dopaminergic neurotransmitter-linked networks predicts variability in acute and chronic poststroke language impairment, offering new insights beyond traditional lesion metrics.
DWI-positive lesions in acute intracerebral hemorrhage patients correlate with cerebral small vessel disease markers and predict poorer 6-month outcomes, with lesion distribution varying by small vessel disease subtype.
A multiprotein plasma panel improves detection of advanced neocortical tau pathology in Alzheimer’s disease risk individuals beyond p-tau217 alone, enhancing patient stratification and clinical trial selection.
This multicenter study characterizes lesion growth variability in adult cerebral adrenoleukodystrophy, highlighting key MRI and biomarker predictors to guide personalized treatment and improve clinical trial designs.
The MINT trial demonstrates that inebilizumab markedly lowers exacerbation rates and rescue therapy use in AChR+ and MuSK+ generalized myasthenia gravis patients undergoing corticosteroid tapering.
The STATICH trial assessed safety and efficacy of antiplatelet therapy after intracerebral hemorrhage, revealing increased hemorrhagic risk but fewer ischemic events among treated patients, highlighting ongoing clinical dilemmas.
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