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The ReCCLAIM II trial demonstrates that rapid systemic hypothermia during mechanical thrombectomy for large-vessel occlusion stroke is feasible without delaying reperfusion, showing trends toward reduced infarct volume but raising safety co
A 6-month longitudinal study identifies younger age, higher resilience, and better health literacy as key predictors of functional ability improvement in traumatic spinal cord injury patients, highlighting targets for tailored rehabilitatio
This study reveals that aggressive electrical stimulation during acute Bell’s palsy recovery may worsen synkinesis and reduce botulinum toxin efficacy, while chronic-phase stimulation improves function, emphasizing a critical cumulati
This study reveals that midlife plasma p-tau181 predicts faster memory decline over 11 years, highlighting a long prodromal phase of Alzheimer’s disease. Late-life biomarkers p-tau181, NfL, and GFAP correlate with accelerated cognitive decl
A large-scale UK cohort study found no strong associations between antibodies against multiple common infections and key Alzheimer’s disease neuropathologies, though possible interactions with APOE ε4 genotype and education warrant further
This study illuminates how APOE ɛ4 accelerates executive function decline while ɛ2 may protect verbal episodic memory in individuals aged 90+, highlighting genetic influences on cognition in exceptional longevity.
This review synthesizes global dementia incidence from the COSMIC consortium, highlighting variations by age, sex, and economic regions, with implications for prevention and resource planning, informed by recent meta-analyses on risk factor
Nationwide analyses show that epilepsy markedly increases the risk of young-onset dementia (YOD) before age 65, with persistent associations even years after epilepsy diagnosis, underscoring the need for YOD risk assessment in epilepsy care
This study evaluates the association between early pregnancy use of anti-CGRP monoclonal antibodies or propranolol and spontaneous abortion risk, finding increased risk with anti-CGRP mAbs but not with propranolol.
This review synthesizes evidence on spinal cord stimulation combined with physiotherapist-led exercise and physical activity prescriptions, highlighting sustained pain relief and quality-of-life improvements without significant increases in
Delpacibart zotadirsen demonstrates an acceptable safety profile and significant increases in exon 44 skipping and dystrophin expression in DMD patients amenable to exon 44 skipping, supporting further phase 3 evaluation.
The OCEANIC-STROKE randomized trial demonstrates that adding asundexian to antiplatelet therapy reduces ischemic stroke without a significant rise in major bleeding, though it increases lower gastrointestinal bleeding in patients with nonca
An eight-season study reveals increased concussion incidence during preseason and full-contact training in men’s English Premiership Rugby, emphasizing the need for strategic training modifications to reduce injury risk.
This review synthesizes evidence on racial and ethnic differences in plasma phosphorylated tau 217 (%p-tau217) in preclinical Alzheimer disease, highlighting implications for diagnostic screening and biomarker validity across diverse popula
This study reveals that lower and declining social integration significantly increase long-term mortality risk after traumatic spinal cord injury, highlighting critical social determinants alongside clinical factors.
The ROAM/EORTC-1308 trial demonstrates that adjuvant radiotherapy after complete surgical resection of atypical meningioma significantly improves 5-year disease-free survival, reducing recurrence risk with manageable adverse effects.
This pooled analysis of INTERACT and ATACH-II trials reveals that intensive blood pressure lowering significantly improves outcomes only in patients with deep intracerebral hemorrhage, highlighting hematoma location as crucial for personali
Office-based vergence/accommodative therapy with movement (OBVAM) significantly improves accommodative amplitude and facility in adolescents and young adults with concussion-related convergence insufficiency, accelerating recovery and funct
This RCT demonstrates that high-intensity laser therapy combined with ulnar nerve gliding exercises yields superior electrophysiological and functional recovery in post-burn cubital tunnel syndrome compared to shock wave therapy or exercise
This article discusses the development and validation of a concise Norwegian tool to assess social cognition deficits in traumatic brain injury patients, maintaining reliability and clinical feasibility compared to the full version.
