Neurology
Latest news
579 articles · 20 / page
Perihematomal Edema Dynamics and Functional Outcomes in Spontaneous Intracerebral Hemorrhage: Insights from a Global IPD Meta-Analysis
This article synthesizes evidence from a large-scale individual participant data meta-analysis, demonstrating that early perihematomal edema growth (at 24 and 72 hours) is an independent predictor of death and disability after intracerebral
Beyond the Blood-Brain Barrier: Skull Bone Marrow TSPO Overexpression as a Novel Biomarker for Multiple Sclerosis Progression
**Refining Content Structure** I’m now deeply immersed in the content. I’ve drafted the introduction, designed to capture attention and set the scene. I am expanding on the key findings, including correlations, and the clinical implications
Beyond the Surface: Why Hip Strength and Gait Speed are the New Gold Standards for Monitoring Late-Onset Pompe Disease
A 2-year longitudinal study reveals that hip strength and walking speed are the most sensitive markers for progression in Late-Onset Pompe Disease, offering clinicians precise thresholds for meaningful intervention.
Precision Diagnostics in Alzheimer’s Disease: Optimizing Plasma p-tau217 Cutoffs for Patients with Comorbidities
This review synthesizes evidence on the impact of kidney function, BMI, and anemia on plasma p-tau217 diagnostic accuracy, advocating for subgroup-specific cutoff strategies to improve clinical outcomes.
Even Mild Bleeding Matters: Redefining Hemorrhagic Transformation Risk with Automated CT Analysis
A large-scale multicenter study demonstrates that all subtypes of hemorrhagic transformation, including mild infractions, significantly impair functional recovery after stroke recanalization. Automated noncontrast CT biomarkers now offer su
Dual-Pathology Burden: How Comorbid Alzheimer’s and FTLD Drive Distinct Neuropsychiatric Phenotypes
This study highlights how comorbid Alzheimer’s and FTLD neuropathologies manifest through unique neuropsychiatric profiles, such as increased anxiety and personality changes, providing clinicians with vital clues for identifying mixed neuro
Precision Rehabilitation for Chronic Stroke: Validating Targeted Ipsilesional Arm Training to Enhance Functional Capacity
A pivotal randomized clinical trial reveals that targeted training of the ipsilesional arm in chronic stroke patients with severe hemiparesis significantly improves motor speed and hand function, with benefits sustained for six months.
Challenging the ‘More is Better’ Paradigm: Intensive Training Shows No Added Benefit in Recent Spinal Cord Injury
A Phase 3 pragmatic trial found that 12 hours of weekly intensive task-specific training added to usual care does not improve motor recovery in recent spinal cord injury patients, suggesting a potential plateau in the benefits of early reha
Long-Term Efficacy and Safety of Transcatheter Patent Foramen Ovale Closure: A 20-Year Follow-Up Study
A 20-year follow-up study of 130 patients demonstrates that transcatheter PFO closure is highly effective in preventing recurrent strokes, though long-term antithrombotic therapy increases bleeding risks, particularly in women.
Differential Pathophysiological Roles of Centrum Semiovale Perivascular Spaces in Cerebral Amyloid Angiopathy and Deep Perforator Arteriopathy: A Biomarker Synthesis
This review synthesizes evidence distinguishing perivascular space enlargement mechanisms in cerebral amyloid angiopathy (CAA) versus deep perforator arteriopathy (DPA), highlighting the diagnostic utility of CSF Aβ42/40 ratios in vascular
Minimally Invasive Endoscopic Techniques Redefine Recovery in Infraclavicular Brachial Plexus Management
Recent clinical evidence demonstrates that endoscopic and arthroscopic techniques for infraclavicular brachial plexus neurolysis and pectoralis minor release provide comparable outcomes to open surgery with significantly reduced morbidity f
Treatment Evolution in 5q-Spinal Muscular Atrophy: Real-World Evidence and Clinical Insights from the SMArtCARE Registry
This review analyzes the shifting landscape of SMA therapy using data from 2,140 patients, highlighting the transition between nusinersen, risdiplam, and onasemnogene abeparvovec and the factors driving treatment switches.
Mapping the Genomic Landscape of Multiple Sclerosis Across Diverse Ancestries: Insights into Shared and Population-Specific Susceptibility
This study demonstrates that while MS genetic risk factors are largely shared across ancestral groups, their predictive power and population-level impact vary significantly between European, South Asian, and African populations.
Low-Dose Lithium for Mild Cognitive Impairment: A Pilot Randomized Clinical Trial and Synthesis of Emerging Neuroprotective Paradigms
This review evaluates a recent 2-year pilot RCT on low-dose lithium carbonate for MCI, synthesizing its findings with emerging evidence on Aβ clearance, gut-brain axis modulation, and multimodal disease forecasting.
Fordadistrogene Movaparvovec Fails to Improve Functional Outcomes in Duchenne Muscular Dystrophy: Insights from the Phase 3 CIFFREO Trial
The Phase 3 CIFFREO trial found that the gene therapy fordadistrogene movaparvovec did not significantly improve motor function in boys with Duchenne muscular dystrophy compared to placebo, leading to the discontinuation of its clinical dev
The Psychological Burden of Watchful Waiting: Anxiety and Depression Linked to Increased Rupture Risk and Mortality in Unruptured Intracranial Aneurysms
A large-scale retrospective study reveals that anxiety and depression following the diagnosis of unruptured intracranial aneurysms significantly increase the risk of rupture and all-cause mortality, suggesting that integrated psychiatric as
Genetic Breakthrough: How SNUPN Gene Variants Lead to Spinocerebellar Atrophy
Researchers have discovered that mutations in the SNUPN gene cause spinocerebellar atrophy by disrupting RNA splicing in Purkinje cells, expanding the understanding of neurodevelopmental disorders beyond muscular conditions.
Age at Onset and Clinical Trajectory in AQP4-IgG NMOSD: Decoupling Relapse Risk from Disability Accrual
This review analyzes how age at onset influences NMOSD, revealing that while relapse risk remains constant across age groups, older onset significantly accelerates disability progression, necessitating early high-efficacy therapy.
Rethinking Rhythm Control for Secondary Stroke Prevention: Insights from the STABLED Randomized Clinical Trial
This review analyzes the STABLED trial findings alongside major AFib rhythm control studies, evaluating the efficacy and safety of catheter ablation added to DOAC therapy for secondary stroke prevention.
Antiepileptogenesis After Stroke: Assessing the Impact of Eslicarbazepine Acetate on Seizure Prevention
This article examines a Phase 2a trial investigating eslicarbazepine acetate for preventing post-stroke epilepsy. While the primary endpoint was not met due to recruitment challenges, the study provides a critical framework for future antie
Browse by specialty
Open language-specific specialty feeds and department pages.