Neurology
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Efficacy and Safety of Ecopipam for Tourette Syndrome: Phase 3 Randomized Clinical Trial
This phase 3 trial found that ecopipam reduced tic relapse and maintained symptom improvement in children and adolescents with Tourette syndrome, with mainly central nervous system side effects and no major weight or metabolic concerns.
Acetazolamide Fails to Improve Gait in Idiopathic Normal Pressure Hydrocephalus: Swedish DRAIN Trial
In a Swedish randomized trial, low-dose acetazolamide did not improve gait in patients with idiopathic normal pressure hydrocephalus and caused more side effects than placebo, arguing against routine use as medical therapy.
Long-Term Wildfire Smoke PM2.5 Exposure Is Linked to Higher Incident Stroke Risk in Older US Adults
In a nationwide Medicare cohort, chronic wildfire smoke PM2.5 exposure was associated with a modest but significant increase in incident stroke, with stronger effects over longer exposure windows.
Application of the AHA-Proposed Cancer-Related Ischemic Stroke Classification: Reclassification and Prognostic Impact
The AHA-proposed CRIS classification reclassified many cancer-associated strokes previously labeled cryptogenic and identified a subgroup with markedly worse survival, improving both etiologic clarity and prognostic stratification.
Midlife Central Obesity Tracks With Higher Late-Life Plasma P-tau217 and Biomarker-Verified Alzheimer Dementia, While the Association Reverses in Old Age
In the HUNT Study, higher midlife waist-to-height ratio and BMI predicted higher late-life plasma p-tau217 and biomarker-verified Alzheimer dementia, whereas higher adiposity in late life was associated with lower biomarker levels and lower
Standard-Dose Tenecteplase vs Low-Dose Alteplase for Acute Ischemic Stroke From Large-Vessel Occlusion: A Randomized Clinical Trial
In a randomized trial of large-vessel-occlusion stroke, standard-dose tenecteplase improved early reperfusion before thrombectomy compared with low-dose alteplase, with similar safety and functional outcomes.
Standard-Dose Tenecteplase vs Low-Dose Alteplase for Acute Ischemic Stroke From Large-Vessel Occlusion: A Randomized Clinical Trial
In patients with large-vessel-occlusion stroke undergoing thrombectomy, standard-dose tenecteplase achieved more early reperfusion than low-dose alteplase, with similar safety and functional outcomes.
New Genetic Modifiers in Autosomal Dominant Alzheimer’s Disease Link Aβ, Tau, TDP-43, and Vascular Biology to Clinical Variability
A genome-wide association study identified CNIH4, CCNG1, and RHOJ as genetic modifiers of autosomal dominant Alzheimer’s disease, with associations spanning disease risk, age at onset, fluid biomarkers, and neuroimaging phenotypes.
Genetic Evidence Strengthens High BMI as a Causal Driver of Vascular Dementia, With Blood Pressure as a Partial Mediator
A 2026 Mendelian randomization study supports high BMI as a causal risk factor for vascular-related dementia, with part of the effect mediated through elevated systolic and diastolic blood pressure.
A Pain-Predominant Dry Eye Phenotype Emerges: Severe Symptoms, Few Ocular Signs, and Strong Links to Migraine and Psychiatric Disease
A 2026 Ophthalmology report identified a pain-predominant dry eye phenotype in 6.9% of patients, marked by high symptom burden, minimal surface signs, and enrichment for migraine and psychiatric comorbidity.
Avoiding Intensive Systolic Blood Pressure Lowering After Successful Thrombectomy May Improve 1-Year Stroke Recovery: The OPTIMAL-BP Extension
In OPTIMAL-BP 1-year follow-up, targeting systolic BP
Teleneurology in Rural General Practice Improved Triage but Did Not Reduce Secondary Care Use in a Stepped-Wedge Randomized Trial
In rural Germany, GP-based teleneurology reduced direct neurology referrals but increased referrals to other specialists and hospitals, suggesting better triage rather than substitution of secondary care.
Rural-Urban Disparity in Postacute Care and 1-Year Outcomes After Ischemic Stroke
Older stroke patients treated in rural hospitals received less inpatient rehabilitation and more skilled nursing facility care than urban patients, with fewer days at home over 1 year but similar overall mortality.
A New Steroid Option for Duchenne Muscular Dystrophy? What the Latest Vamorolone Study Means for Families
A new study suggests vamorolone may preserve motor benefits seen with standard steroids in Duchenne muscular dystrophy while better protecting growth, though weight gain remains a concern.
Effect of Electroacupuncture on Postherpetic Neuralgia: A Randomized Clinical Trial
A randomized clinical trial found that electroacupuncture reduced pain more than sham treatment in postherpetic neuralgia, with benefits lasting at least one month and no major safety concerns.
GLP-1 Receptor Agonist Use Linked to Lower Risk of Brain Aneurysm Rupture and Less Severe Bleeding
A large real-world study found GLP-1 receptor agonist use was linked to a lower risk of intracranial aneurysm rupture and milder bleeding severity if rupture occurred.
French Registry Data Show Marked Declines in Relapse Activity and Faster Diagnosis in AQP4+NMOSD and MOGAD From 2010 to 2024
A nationwide French cohort found earlier diagnosis, falling relapse rates, and major treatment shifts in AQP4+NMOSD and MOGAD, with rituximab linked to lower disability risk in AQP4+NMOSD and overall milder disability trajectories in MOGAD.
Digital Sleep-Wake Cycle Metrics and Dementia Prediction in Older Adults
Wearable accelerometer sleep-wake patterns were linked to later dementia risk in two UK cohorts and modestly improved prediction beyond age and standard risk factors.
Intravenous Magnesium Sulfate for Acute Nontraumatic Headache in the Emergency Department
Intravenous magnesium sulfate added to paracetamol increased early headache-treatment success in the emergency department, but the pain relief was modest and below usual clinical importance thresholds. It also reduced rescue analgesia needs
Earlier Cricopharyngeal Intervention May Improve Oral Intake in Absent UES Opening After Neurological Injury
A small retrospective series suggests that cricopharyngeus-targeted procedures can improve upper esophageal sphincter opening and oral intake after neurological injury, but aspiration risk often persists and ongoing swallowing therapy remai
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