Section
Two phase 3 trials establish remibrutinib, a BTK inhibitor, as more effective and better tolerated than teriflunomide in relapsing multiple sclerosis, supporting its potential as a new oral treatment.
A long-term follow-up of the SPRINT trial shows no significant difference in recurrent stroke or mortality rates between initial low and moderate fixed doses of hydroxyurea in sickle cell disease, emphasizing event clustering within the fir
US emergency departments increasingly discharge transient ischemic attack patients with extensive imaging, reflecting a shift from inpatient to expedited outpatient evaluation, raising questions about cost, feasibility, and rural healthcare
The RCBI trial demonstrates that targeted interventions beginning prior to release and continuing postrelease significantly reduce recidivism and improve coping and executive function in incarcerated men with traumatic brain injury.
The LAST-long trial investigated a community-based, individualized stroke intervention and found that age—but not frailty—significantly modifies its effectiveness, with older stroke survivors (≥80 years) experiencing less favorable outcomes
Hydrocephalus is a multifaceted neurological disorder caused by cerebrospinal fluid imbalance. This review explores current surgical treatments, emerging technologies, molecular mechanisms, and challenges in managing hydrocephalus effective
This review synthesizes evidence from the PROOF-HD placebo arm and related studies, demonstrating that antidopaminergic medication use in Huntington disease correlates with accelerated decline in functional, motor, and cognitive outcomes, e
A clinician-led computer vision system enables accurate, feasible, and usable postural assessment in acquired brain injury rehabilitation, demonstrating significant alignment with clinical evaluations and motion capture data.
This feasibility RCT demonstrates that the HOPE4ABI digital intervention is acceptable and beneficial for improving mental, sexual wellbeing, and quality of life in stroke and brain injury survivors, warranting a definitive efficacy trial.
This study evaluates the sustainment of brief behavioral insomnia treatments in VA primary care mental health clinics after implementation support ended, showing increased therapy delivery and reduced sleep medication prescriptions.
A pharmacovigilance study using EudraVigilance data highlights potential safety signals linking desogestrel-only and drospirenone-only hormonal therapies with meningioma, underscoring the need for further longitudinal research and cautious
This article reviews a 13-year longitudinal study assessing blood-based biomarkers’ effectiveness in predicting all-cause dementia among community-dwelling older adults, highlighting their modest sensitivity and enhanced predictive value wh
This article reviews evidence supporting OCT measurements of retinal layers as biomarkers for predicting multiple sclerosis progression and highlights the need for further research to enhance clinical application.
A Swedish cohort study reveals increased risk of inflammatory bowel disease in relapsing-remitting multiple sclerosis patients treated with rituximab compared to other therapies and the general population, underscoring the need for gastroin
A cross-sectional study used latent profile analysis to identify distinct quality of life outcome profiles in rehabilitation patients with traumatic brain injury, spinal cord injury, stroke, and limb injuries, highlighting heterogeneous pat
A randomized controlled trial demonstrates that bimodal biofeedback using accelerometer and nasal airflow sensors significantly improves swallowing function in post-stroke dysphagia patients undergoing supraglottic swallowing training.
This multicenter study reveals that nearly 60% of cervical artery dissection patients achieve complete vessel recanalization at 6 months. Older age, diabetes, smoking, and initial complete occlusion markedly reduce recanalization odds, with
A pragmatic RCT suggests that exercise following spinal cord injury guidelines may reduce chronic pain intensity, with significant benefits observed in pain interference and coping strategies.
This study reveals persistent worse functional outcomes after ischemic stroke among Black patients, largely influenced by stroke severity, premorbid health, and social determinants, highlighting targets for intervention during recovery.
This exploratory trial compares cobratide injection and pregabalin for moderate-to-severe acute herpes zoster neuralgia, showing similar pain relief with better tolerability for cobratide and a potential reduction in postherpetic neuralgia
