Neurology
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Long-Term Cognitive Recovery After Stroke: What the Oxford Cognitive Screen Reveals
A long-term stroke study found that cognition improves most within 6 months, with memory and language recovering better than executive function. Early cognitive impairment was the strongest predictor of outcomes years later.
Fixed-Dose Tavapadon for Early Parkinson Disease: A Randomized Clinical Trial
In a phase 3 trial, once-daily tavapadon improved motor symptoms in people with early Parkinson disease and was generally well tolerated, with nausea, headache, and dizziness as the most common side effects.
Prior Myocardial Infarction and Cognitive Decline: Insights from the REGARDS Cohort
In the REGARDS cohort, prior myocardial infarction, including silent MI, was linked to faster long-term cognitive decline, suggesting heart attack history may help identify people at risk for future cognitive impairment.
Safety and Outcomes of Dabigatran Reversal With Idarucizumab Before IV Thrombolysis in Acute Ischemic Stroke
Real-world registry data suggest that reversing dabigatran with idarucizumab before IV thrombolysis in acute ischemic stroke is safe and yields outcomes similar to patients not on oral anticoagulants.
Effects of Exercise and Intensive Vascular Risk Reduction on Cognitive Function in Older Adults: A Randomized Clinical Trial
A 24-month randomized trial found that exercise, intensive blood pressure and cholesterol control, or both together did not significantly improve cognitive function in older adults at increased risk for dementia.
Patient-Derived Neuronal Synapse Deficits Predict Brain Network Abnormalities and Cognitive Impairment in Schizophrenia
A multimodal translational study links genetically driven synaptic deficits in patient-derived neurons to cortical structure, electrophysiology, and cognition in schizophrenia, supporting biologically informed stratification of cognitive im
Sham-Controlled Trial Finds Translumbosacral Neuromodulation May Reduce Fecal Incontinence
In a sham-controlled trial, translumbosacral neuromodulation with 2400 or 3600 magnetic pulses reduced fecal incontinence episodes, improved severity scores and quality of life, and was well tolerated, with the higher dose showing the stron
Systemic Cardiovascular Factors and Outcomes in Dural Arteriovenous Fistulas: Insights From the CONDOR Registry
A large international registry study found that hemorrhage in dural arteriovenous fistulas is driven mainly by venous anatomy and lesion grade, not most cardiovascular comorbidities. Surgery was most associated with angiographic cure, and b
Cerebral “Dirty-Appearing” White Matter and Its Link to Cognitive Decline and Dementia Risk
In older adults with limited small vessel disease, “dirty-appearing” white matter on MRI was not linked to baseline cognition, cognitive decline, or dementia risk, unlike conventional white matter hyperintensities.
Treatment Discontinuation in Patients With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease
In adults with MOGAD, stopping maintenance therapy was associated with a low 1-year relapse risk, especially after longer treatment and a longer relapse-free interval. The findings support individualized decisions and close follow-up after
DISTAL at 12 Months: No Functional or Survival Advantage for Endovascular Therapy in Mild-to-Moderate Medium or Distal Vessel Occlusion Stroke
The DISTAL trial found no 12-month disability or survival benefit from adding endovascular treatment to best medical therapy in mild-to-moderate medium or distal vessel occlusion stroke.
Weak Grip, Slow Walking Pace, and Sarcopenia Signal Higher Risk of Incident Stroke and Worse Poststroke Survival in UK Biobank
In nearly 483,000 UK Biobank participants, sarcopenia, low grip strength, and slow walking pace were associated with higher risks of incident stroke and poorer survival after stroke.
Multiple Sclerosis End-of-Life Care Remains Hospital-Centered Despite Comparable Palliative Care Use
A large Ontario population study found that people with multiple sclerosis received palliative care at rates similar to other decedents, yet rural inequities and frequent hospital death persisted, highlighting the need for earlier neuropall
Adjunct Intra-arterial Alteplase After Successful Basilar Thrombectomy Was Safe but Did Not Improve 90-Day Outcomes in IAT-TOP
In the IAT-TOP randomized trial, intra-arterial alteplase after successful EVT for acute basilar artery occlusion did not improve 90-day functional independence, while symptomatic intracranial hemorrhage and mortality were similar between g
Earlier IV Thrombolysis Before Thrombectomy Was Linked to Better In-Hospital Stroke Outcomes in RES-Q
A large multinational RES-Q registry analysis suggests that the benefit of bridging thrombolysis before thrombectomy is greatest when treatment starts very early, with attenuation after 150 minutes.
Higher Amyloid PET Signal and Lower APOE ε4 Frequency Distinguish Iatrogenic From Sporadic Cerebral Amyloid Angiopathy
A single-center cross-sectional study found that iatrogenic cerebral amyloid angiopathy carries a higher amyloid PET burden, weaker CSF-PET coupling, and less APOE ε4 enrichment than sporadic disease, supporting a biologically distinct mech
Oral Factor D Inhibition Falls Short in AChR-Positive Generalized Myasthenia Gravis: What the Vemircopan Phase 2 Trial Means for Complement-Targeted Therapy
In a phase 2 randomized trial, oral vemircopan did not improve clinical outcomes over placebo in AChR-antibody–positive generalized myasthenia gravis, despite a mechanistically attractive strategy to selectively inhibit the alternative comp
Wider Cranial Arteries, Not Atherosclerotic Stenosis, Track With Lacunar Stroke and Cerebral Small-Vessel Disease
In a prospective mild stroke cohort, cranial arterial dolichoectasia and larger intracranial arterial diameters were linked to lacunar stroke, cSVD burden, and incident infarcts, whereas large-artery stenosis was not.
Education and Neighborhood Resources Explain Much of the Racial and Ethnic Gap in Timely Dementia Diagnosis
Among older U.S. adults with dementia, non-Hispanic Black and Hispanic individuals were significantly less likely than non-Hispanic White individuals to receive a timely diagnosis, with education and neighborhood affluence explaining much o
Pregnancy Outcomes Among Individuals With Cerebral Palsy: A Population-Based Cohort Study
Canadian research reveals individuals with cerebral palsy face significantly higher risks of severe maternal complications, preterm birth, and neonatal issues during pregnancy, highlighting the need for specialized perinatal care.
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