Neurology
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Nine-Year Outcomes After Lacunar and Mild Cortical Ischemic Stroke: Long-Term Functional, Cognitive, and Vascular Impacts
This longitudinal study reveals persistent cognitive, physical, and vascular challenges up to 9 years after minor lacunar or cortical ischemic stroke, emphasizing different risks and recovery patterns by stroke subtype.
The Science Behind a Cup of Hot Green Tea: Enhancing Memory and Brain Connectivity
A 12-week clinical trial reveals that heat-treated green tea extract can significantly improve memory and brain network connectivity in middle-aged adults with subjective memory concerns.
Physical Exercise Slows Neurodegeneration and Cognitive Decline in Early Parkinson Disease: Insights from Longitudinal MRI Analysis
Regular physical activity in early Parkinson disease patients is linked to slower brain atrophy in temporoparietal and limbic regions, mediating better preservation of memory and attention over four years.
Harnessing Mobile Health to Improve ADHD Symptoms and Executive Functions in Children: A Randomized Controlled Trial of Tailored Exercise Rehabilitation
A tailored, app-supported exercise program delivered via mobile health significantly improves core ADHD symptoms and executive functions in children, demonstrating comparable effectiveness to traditional face-to-face exercise guidance.
Recent Advances in Cinnamon and Its Extracts: Clinical Applications and Therapeutic Potentials Across Metabolic, Cardiovascular, Cognitive, and Infectious Diseases
A decade of research highlights cinnamon’s benefits in glycemic control, lipid modulation, anti-inflammatory effects, cognitive enhancement, and antimicrobial activity, supporting its adjunctive clinical use and revealing promising therapeu
Sulforaphane in Clinical Medicine: A Decade of Research Progress and Therapeutic Potential
This review synthesizes 10 years of sulforaphane (SFN) research, highlighting its pharmacology, clinical trial outcomes, and emerging therapeutic prospects across cancer, metabolic, renal, neurodevelopmental, and cardiovascular disorders.
Stroke Strikes Silently but Is 90% Preventable: Recognize the Warning Signs and Act Fast
Stroke, a sudden interruption of brain blood flow, can lead to severe disability or death but is largely preventable. Early recognition and timely intervention can save lives and reduce complications.
Apitegromab (SAPPHIRE): phase 3 trial shows modest motor gains in non‑ambulatory type 2/3 spinal muscular atrophy on SMN therapies
The SAPPHIRE phase 3 trial found that adding apitegromab to nusinersen or risdiplam produced a small but statistically significant improvement in motor function in children aged 2–12, with a safety profile similar to placebo.
Unlocking Dementia Prevention in Brazil: Impact of 14 Modifiable Risk Factors on Reduction Potential
Nearly 60% of dementia cases in Brazil could be prevented by addressing 14 modifiable risk factors, highlighting a crucial public health opportunity in a middle-income country setting.
Unveiling the Impact of Pre-Clinical Alzheimer’s Disease on Blood Pressure: Insights from UK Biobank Mendelian Randomisation Studies
This study presents compelling evidence that pre-clinical Alzheimer’s disease increases systolic blood pressure, using innovative Mendelian randomisation and parental dementia instruments in UK Biobank data. These findings highlight complex
High-sensitivity cardiac troponin I levels are associated with Alzheimer’s disease in women?
Elevated hs-cTnI levels below myocardial injury thresholds associate with increased late-life dementia risk in older women, highlighting cardiovascular biomarkers’ potential to identify vulnerable individuals for dementia prevention.
Harnessing Exosomes in Neurodegenerative Diseases: Therapeutic Promise and Modification Techniques
Exosomes, nanoscale vesicles capable of crossing the blood–brain barrier, hold significant potential as targeted therapeutic agents and diagnostic markers in neurodegenerative diseases. Advances in genetic, chemical, and nanomaterial modifi
FDA Approves Tonmya: First Nonopioid Sublingual Treatment Targeting Sleep in Fibromyalgia
The FDA has approved Tonmya (sublingual cyclobenzaprine) as the first new fibromyalgia therapy in 15 years, targeting nonrestorative sleep to alleviate pain, fatigue, and cognitive symptoms in adults.
Thrombolysis Before Thrombectomy May Raise ICH Risk After Stroke: A Comprehensive Review of Recent Evidence
A meta-analysis of over 2000 stroke patients found that intravenous thrombolysis (IVT) before endovascular treatment (EVT) modestly increases intracranial hemorrhage (ICH) risk, especially in patients with elevated glucose and blood pressur
Prenatal Exposure to Chlorpyrifos and Its Long-Term Impact on Brain Development and Motor Function in Children: Evidence from Imaging and Cohort Studies
Elevated prenatal chlorpyrifos exposure is linked to widespread brain structural abnormalities, reduced neuronal density, and impaired motor functions in children, underscoring the need for exposure minimization during pregnancy.
Modern Pain Neuroscience Approach Versus Usual Care in Chronic Whiplash Disorders: Evidence from a Randomized Clinical Trial
This review analyzes a randomized clinical trial comparing modern pain neuroscience approach and usual care physiotherapy in chronic whiplash disorders, highlighting immediate and 12-month improvements, cost-effectiveness, and benefits in a
Transcranial Magnetic Stimulation: Clinical Advances, Challenges, and Emerging Research Trends
This review synthesizes recent clinical evidence on transcranial magnetic stimulation across neurological and psychiatric disorders, highlighting efficacy, optimization challenges, and future research directions.
Advances on Remote Ischemic Preconditioning for Cardiac and Cerebral Ischemic Protection
This review synthesizes recent PubMed-indexed evidence on remote ischemic preconditioning (RIPC) demonstrating its protective effects on cardiac and cerebral ischemia, highlighting clinical trial progress, mechanistic insights, and therapeu
Clinical Therapeutic Value of Curcumin Supplementation in Cardiovascular Disease, Diabetes, Cognitive Function, Aging, and Neurodegenerative Disorders: A Synthesis of Recent Evidence
Current evidence supports curcumin supplementation for reducing cardiovascular risk factors and preventing type 2 diabetes progression, with emerging potential in cognitive decline and aging-related degenerative diseases.
Protective Effects of High-Intensity Interval Training on Cardiovascular, Neurological, and Metabolic Health: An Evidence-Based Review
This review synthesizes recent evidence demonstrating that high-intensity interval training (HIIT) confers cardiometabolic benefits, modulates microvascular and neural function, enhances insulin sensitivity, and improves mental health outco
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