Disability Dynamics Independent of Attacks in AQP4-IgG+ NMOSD and MOGAD: Insights from a Multicenter Cohort Study

Highlight

• Confirmed disability improvement (CDI) and confirmed disability worsening (CDW) independent of attacks occur in both AQP4-IgG+ NMOSD and MOGAD patients, albeit infrequently.
• Lower prior attack number correlates with higher CDI rates in AQP4-IgG+ NMOSD, underscoring the importance of early attack prevention.
• Younger patient age is associated with increased chances of disability improvement in both diseases.
• Annualized CDI and CDW rates are comparable between AQP4-IgG+ NMOSD and MOGAD.

Study Background